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Complete omission of exon 21 from Slc12a2 transcripts in mice results in hearing loss
Network topology and entropy analysis of tetragonal farneseite zeolites
Abstract Topological indices and their entropies of networks of complex materials and chemical structures are vital for quantitative structure activity and property relationship studies. Computing these measures for complex three-dimensional (3D) crystalline frameworks has been challenging owing to their sizes and complexities. Tetragonal zeolite farneseite (FAR) is a mineral from the cancrinite sodalite group with potential applications in the field of microelectronics, medicine, environment, and industry. We have obtained generalized expressions for the various indices and entropies of these complex networks using a graph theoretical cut method to compute distance-based indices for the FAR framework. With the aid of computed indices and Shannon’s entropy formula, we explore the structural complexity of the frameworks. The present study reveals that the bond-wise entropies of sodalite (SOD) frameworks are greater compared to the farneseite-type frameworks which would have significant ramifications on phase transitions and other phenomena pertinent to such complex structures that typically undergo metamorphosis from one structural network topology to another complex network.
The role of pH on structure, corrosion behavior and biocompatibility of MgFe layered double hydroxide coating on Mg–Nd–Zn–Zr alloy
Interaction of gibberellic acid, potassium nitrate and role of pollen sources on physicobiochemical traits of grape
Statistical analysis of EBSD data confirms pronounced classical and non-classical pervasive crystallographic twinning in rotaliid foraminiferal calcite
Abstract We describe a quantitative statistical and geometric analysis of classical and non-classical modes of twinning in the calcite produced by biomineralization in the shell of the rotaliid foraminifer species Amphistegina lessonii. Foraminifera are responsible for about a quarter of the marine production of CaCO 3 and thus play a major role in the natural CO 2 sequestration into marine carbonate sediments. The shell calcite of rotaliid foraminifera is nano-twinned and thus quite distinct from inorganic calcite and from biogenic calcite produced by other groups of organisms. Previous work showed that foraminiferal calcite contains a high spatial density of twin walls of the classical 60°|<001> = m.{001} twin, but there was another peak in the range between 75° and 80° in the misorientation statistics of electron backscatter diffraction (EBSD) maps of the same specimen. We checked the significance of all maxima in misorientation by in-depth statistical analysis, thus confirmed the 60°|<001> penetration twinning and found that the 75°–80° maxima are related to new, non-classical, but systematically reoccurring oriented associations of calcite crystals with orientation relationships 78.2°|<991> and 76.6°|<6 −6 1>. If the nano-twinning provides an evolutionary advantage, it may increase the strength and toughness of the feeble mineralized chamber walls of the organisms.
The interconnection of oral and systemic health
Exploration of selenophene analogue and different acceptor influence on photovoltaic properties of pyrrole-4,6(5-H)-dione based chromophores via quantum chemical investigations
Study on the evolution of ecological environment and irrigation behavior since mulched drip irrigation in Yanqi basin, Xinjiang
Optical coherence tomography surpasses fundus imaging and intracranial pressure measurement in monitoring idiopathic intracranial hypertension
Abstract We aim to evaluate the retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT) in comparison with papilledema grade, and to assess the relationship between RNFL thickness, papilledema grade, and intracranial pressure (ICP) in idiopathic intracranial hypertension (IIH). Sixty-five patients with active IIH (AIIH) with papilledema, 39 with chronic IIH (CIIH) without papilledema and 80 healthy controls (HC) were examined with OCT and fundus imaging. RNFL thickness, papilledema grade and ICP level were assessed in 55 with AIIH and 26 with CIIH. RNFL thickness was significantly higher in AIIH compared to CIIH or HC. RNFL thickness correlated strongly with papilledema grade (coefficient 0.78, p < 0.01) and moderately with ICP (coefficient 0.569, p < 0.01). RNFL thickness was associated with papilledema progression (R2 = 0.656, p < 0.01): specifically, with increases of 9 µm from normal to mild grade (p > 0.05), 91 µm from normal to moderate (p < 0.01), and 214 µm from normal to severe (p < 0.01). ICP showed a weaker correlation with papilledema grades (R2 = 0.339, p < 0.05), with significant increase (8 cm H2O, p < 0.01) only from normal to severe papilledema. RNFL correlated strongly with papilledema grade and moderately with ICP levels. RNFL thickness increased proportionally per papilledema grade.
Latent profile analysis of anxiety, depression, and resilience among elderly colorectal cancer patients in China
A U shaped association between the HCT-ALB and hospital mortality in patients with sepsis
Multi-objective layout optimization of hospital outpatient clinics based on NSGA II
Expression analysis and functional study of honeysuckle MYB transcription factors under drought stress
Association of immunonutritional indicators with all-cause mortality in adult stroke patients
Author Correction: Anopheles mosquito fauna, blood meal sources and transmission intensity from high and moderate malaria endemic areas of Ethiopia
Application of neutron grating interferometry and tomography to the nineteenth century Korean copper coins
Risk factors, prognostic factors, and nomograms for liver metastasis in stage Tis-T2 colorectal cancer patients from a population-based study
Sodium butyrate promotes synthesis of testosterone and meiosis of hyperuricemic male mice
MuSK is a substrate for CaMK2β but this interaction is dispensable for MuSK activation in vivo
Abstract The neuromuscular junction (NMJ) is the unique interface between lower motor neurons and skeletal muscle fibers and is indispensable for muscle function. Tight control of its localized formation at the center of every muscle fiber, and maintenance throughout lifetime are sustained by muscle-specific kinase (MuSK). MuSK acts as central regulator of acetylcholine receptor clustering at the postsynapse. Localized and temporally controlled signaling of MuSK is primarily achieved by tyrosine autophosphorylation and inhibition thereof. Previous investigations suggested serine phosphorylation of the activation domain as an additional modulator of MuSK activation. Here we identified calcium/calmodulin dependent protein kinase II (CaMK2) and in particular CaMK2β as novel catalyst of MuSK activation and confirmed its capability to phosphorylate MuSK in heterologous cells. However, whereas CaMK2β absence in muscle cells reduced AChR clustering, MuSK phosphorylation was unchanged. Accordingly, we ruled out MuSK phosphorylation as the cause of synapse fragmentation in a mouse model for myotonic dystrophy type 1, in which the muscle-specific splice-variant of CaMK2β is missing, or as the cause of ataxia or delayed muscle development in CaMK2β knockout animals. Histological characterization of muscles of CaMK2β knockout mice indicated specific roles of CaMK2β in fast glycolytic versus slow oxidative muscle. Taken together, our data shows that MuSK can be phosphorylated by CaMK2β, but loss of CaMK2β is likely compensated by other CaMK2 paralogs at the NMJ.