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An evolutionary prediction model for enterprise basic research based on knowledge graph
Association between ACTN3 (R577X), BDKRB2 (−9/+9) and AGT (M235T) polymorphisms and physical performance in Brazilian junior handball players
First experience in employing a complex digital support system accompanied by personal assistance to improve aftercare in patients with stroke or transient ischemic attack – results of the PostStroke-Manager feasibility study
Abstract Stroke aftercare is widely acknowledged as crucial yet challenging. Digital tools offer a promising strategy to improve aftercare and, thus, patients’ quality of life. However, it has not yet been investigated whether digital tools addressing different aspects of aftercare at the same time can be utilized in stroke patients. This study was intended to gain first experience in employing a complex patient-centered digital support system (i.e., the PostStroke-Manager) in individuals with stroke or transient ischemic attack (TIA) and thus examined its feasibility accompanied by personal assistance. This cohort study was carried out to enroll patients with stroke or TIA. Digital support was realized through an application installed on a tablet, a smartwatch, and a blood pressure monitor. Trained nurses, referred to as stroke pilots, provided personal assistance. After 6 or 12 months, patients were asked to evaluate the concept with digital and personal support as a whole and concerning single components of the program for individually experienced beneficial effects. Additional descriptive analyses comprised temporal courses of stroke-related impairments, quality of life, anxiety, depression, adherence, empowerment, blood pressure, LDL cholesterol, and HbA1c levels. Between January 2022 and December 2022, 815 patients were screened, and 43 were included in the study, of whom 36 completed follow-up assessments. The study met its predefined feasibility criterion, with at least 50% of program components receiving positive ratings from at least 75% of patients. The digital system as a whole (77.8%), personal assistance (75.0%), and interactions with stroke pilots (77.8%) received particularly positive ratings. Additionally, aspects such as vital sign monitoring, platforms for communication and medical records were rated positively. Longitudinal analyses revealed improvements in patients’ impairments, blood pressure, and LDL cholesterol levels, while most psychometric measurements remained stable. These findings indicate the feasibility of employing complex digital support systems for patient-centered aftercare in selected individuals with stroke or TIA. The challenge remains in extending benefits to those patients with more severe neurological impairments, highlighting the necessity for ongoing advancement in this field.
Excessive lymph node dissection increases postoperative cardiovascular disease risk in non-small cell lung cancer patients
Seroprevalence of Hepatitis A virus infections among schoolchildren in Amran Governorate, Yemen
Fe3O4@SiO2/Schiff-base/Zn (II) nanocomposite functioning as a versatile antimicrobial agent against bacterial and fungal pathogens
The effects of dry density and moisture content on the shear characteristics of clay-type muddy interlayer
Severe decline of Gongolaria barbata (Fucales) along most of the French Mediterranean coast
Risk assessment of femoral head AVN following reduction and fixation of intracapsular hip fractures in patients younger than 65 years over a 10 year follow up
Research on rechargeable agricultural wireless sensor network based on ZigBee immune routing repair algorithm
Nonlinear mixed-effects models to analyze actin dynamics in dendritic spines
Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status
Multiple objectives escaping bird search optimization and its application in stock market prediction based on transformer model
Carotid revascularization improves cognition in patients with carotid stenosis
Examination of factors associated with physical activity among medical students pre and post-COVID-19 in Serbia
Towards a reduced order model of the periodontal ligament
Abstract Based on previous in vitro experiments with specimens of porcine mandibular premolars, the simulation of the periodontal ligament response to force in the initial phase of orthodontic tooth movement is described. The initial response of the periodontal ligament can be simulated with a poro-visco-hyperelastic model. For the ground substance a hyperelastic constitutive model for compressible material was used. To facilitate parameter identification a reduced order model and an optimal interpolation metamodel were used. Parameters for the constitutive model identified herein are in good agreement with published values. They indicate a high initial compressibility of the periodontal ligament, which may be attributed to the compressibility of the vascular system within the periodontal ligament. Dimensionless analysis suggests that poroelastic behaviour will gradually cease when viscoelastic relaxation progresses. This was observed as well in the simulation and confirmed by varying the poroelastic model parameters within physically justified limits. Alveolar bone permeability has a significant influence on the flow of pore fluid in the periodontium due to poroelasticity. It is argued that in vivo alveolar bone perforation may adapt locally to optimise for the predominant load situation. A strain rate hardening effect was observed, which is not covered by the simulation, and may be the subject of further investigations.