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Copper and iron as unique trace elements linked to fibromyalgia risk

Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of calcium

Biopharma dealmaking in 2024

Exploring health related quality of life for women with breast cancer in Ireland and Québec, Canada throughout the COVID-19 pandemic

Abstract The long-term consequences from the COVID-19 pandemic on breast cancer (BC) is highly unknown, however persisting unmet needs and psychosocial difficulties are likely. The objectives of this study were to evaluate the change in health-related quality of life (HR-QoL) from the pandemic to post-pandemic for women living with a diagnosis of BC and to assess the association between COVID-19 stressor impact and HR-QoL in Ireland and Québec, Canada. Women with a diagnosis of BC were initially enrolled in the cohort study. HR-QoL was assessed during the pandemic (2020–2021) and post-pandemic periods (2022). COVID-19 stressor impact was computed post-pandemic, and change in HR-QoL during and post-pandemic was compared between Ireland and Québec using independent t-tests. Multivariable analysis of covariance (ANCOVA) was used to evaluate the association between COVID-19 stressor impact and changes in HR-QoL, and compare it between Ireland and Québec. 405 participants were included from both settings (Ireland n = 267; Québec n = 138). The average HR-QoL improved from the COVID-19 pandemic to post-pandemic, and there were no differences between Ireland and Québec. Women with high COVID-19 stressor impact (18.9% of participants) had a significantly smaller improvement in their overall HR-QoL compared to those with low COVID-19 stressor impact, and this was evident in Ireland (p < 0.004) and Québec (p < 0.0001) but there were no significant differences between Ireland and Québec (interaction p-value > 0.05). Overall, HR-QoL for women with BC improved from pandemic to post-pandemic period. However, similarly in both settings, women who experienced higher levels of COVID-19-related stress had a slower recovery in HR-QoL. These results can guide decisions about health services and policies to adequately address the on-going effect of the pandemic and also prepare for future health crises.

Targeting the mitotic kinase NEK2 enhances CDK4/6 inhibitor efficacy by potentiating genome instability

Outlook for medicines development and use in 2025

Integrative computational analysis of anti-influenza potential in Caesalpinia mimosoides Lamk hydroethanolic extract

Recent advances in the synthesis and application of biomolecular condensates

In-situ observation of nanoscale transformations in dehydrating lizardite

Imaging-based quantitative assessment of biomolecular condensates in vitro and in cells

DLL3 draws two antibody–drug conjugate deals

Ningxiang pig-derived Lactobacillus reuteri improves the gut health of weaned piglets by regulating intestinal barrier function and cytokine profiles

Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament

Targeting inherited mutations to prevent metastasis

Enhancing maize seed resistance to chilling stress through seed germination and surface morphological changes using high voltage electrostatic field

Laser-capture microdissection for spatial transcriptomics of immunohistochemically detected neurons

FDA approves next-generation triple therapy for cystic fibrosis

Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway

Inhibition of L-threonine dehydrogenase from Trypanosoma cruzi reduces glycine and acetate production and interferes with parasite growth and viability

Cough suppressant reverses lung scarring