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Author Correction: Association of higher potency statin use with risk of osteoporosis and fractures in patients with stroke in a Korean nationwide cohort study
Effect of substituting Al with Zn on the microstructure and mechanical properties of the as-cast Mg–4Y–4Al alloy
Sex-specific variation in breeding-ground departure decisions and detection rates during southbound migration in West Atlantic Flyway Whimbrels (Numenius phaeopus)
An improved salp swarm algorithm for permutation flow shop vehicle routing problem
Risk-benefits assessment of tamoxifen or raloxifene as chemoprevention for risk reduction of breast cancer among BRCA1 and BRCA2 carriers: a meta-analysis
Machine learning for early diagnosis of Kawasaki disease in acute febrile children: retrospective cross-sectional study in China
CC-chemokine ligand 18, CXC motif chemokine 13 and osteopontin as biomarkers of silicosis and asbestosis: a prospective observational study
Paleoenvironmental and paleobiogeographical significance of Paleocene – early Eocene ostracods in Wadi Tarfa, North Eastern Desert, Egypt
Abstract This study investigates ostracod faunas from the well-preserved Paleocene to lower Eocene sedimentary succession at Wadi Tarfa, North Eastern Desert, Egypt. A total of 22 species and subspecies across 16 genera and 8 families were identified across 57 samples. Three zones were identified: Doricythereis jordanica jordanica Zone, Cytheropteron toshkaensis Zone, and Phalcocythere horraensis Zone, based on the stratigraphic distribution of ostracod fauna. However, correlations with other sections revealed inconsistencies in the first and last occurrences of ostracod species, indicating complexities in regional biostratigraphic correlation by ostracod fauna and the influence of localized depositional factors. Both R-mode and Q-mode clustering analyses were applied to ostracod assemblages, identifying four distinct faunal clusters and five biofacies, reflecting depositional changes from outer neritic to upper bathyal environments. The late Paleocene revealed reduced ostracod diversity, correlating with a deepening marine environment, particularly in the Tarawan Formation. Non-Metric Multidimensional Scaling (NMDS) analyses indicated significant paleobiogeographic connections between North African and Levantine sites, while faunal differentiation was greater in West African and Middle Eastern regions due to marine barriers.
Generalized conversion of (2n + 1)-point binary to 3n + 1-point quaternary subdivision schemes
Retraction Note: Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways
Abundant soliton solutions in saturated ferromagnetic materials modeled via the fractional Kraenkel–Manna–Merle system
A nomogram for predicting cancer-specific survival in patients with rectal mucinous adenocarcinoma following surgery
Suzi Daotan Decoction alleviates asthmatic airway remodeling through the AMPK/SIRT1/PGC-1α signaling pathway and PI3K/AKT signaling pathway
Enhanced methane production from bloom algal biomass using hydrothermal and hydrothermal-alkaline pretreatment with anaerobic digestion
3D porous structure of ionic liquid-delaminated Ti3C2 MXene nanosheets for enhanced electrochemical sensing of tryptophan in real samples
Proposal of integrated clinical pathway in the management of perioperative recurrent laryngeal nerve injury post thyroid and parathyroid surgery
A study on the design of literacy toy for children with parent-child interactions
Equus mitochondrial pangenome reveals independent domestication imprints in donkeys and horses
Identification of AK4 and RHOC as potential oncogenes addicted by adult T cell leukemia
Adult T cell leukemia (ATL) is a highly aggressive T cell malignancy characterized by human T cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify potential targets in ATL cells in order to develop effective targeted therapeutics. Here, we report the identification of two oncogenes, AK4 and RHOC, as target genes of miR-455-3p, a tumor-suppressive microRNA in ATL patients. Importantly, AK4 and RHOC are highly expressed in ATL and exhibit oncogenic potentials in vitro and in vivo. Interestingly, transcriptome and metabolome analyses reveal a functional overlap of AK4 and RHOC, including activating oncogenic pathways such as Myc targets and deregulating lipid metabolism such as enhancing the production of sphingomyelin, a tumor-promoting lipid. In particular, compared to other types of T cell malignancy such as T cell acute lymphoblastic leukemia (T-ALL) and cutaneous T cell lymphoma (CTCL), ATL is sensitive to sphingomyelin inhibition and AK4 or RHOC depletion. Altogether, we report a distinct dependency of ATL on AK4 and RHOC oncogenes and an oncometabolite sphingomyelin, which together represent targetable vulnerabilities of ATL that could be exploited for developing effective therapeutics.