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A study on surrounding rock characteristics inducing severe large deformation in tunnels and methods for determining its strength
Advanced control scheme for harmonic mitigation and performance improvement in DC-AC microgrid with parallel voltage source inverter
The mediating role of psychological capital in the association between work engagement and occupational stress in pediatric nurses
An exploration of the effect of Belt and Road Initiative on carbon emissions embodied in China’s manufacturing industry exports
Geographical location and genotyping analysis of pulmonary tuberculosis in the state of Nuevo Leon, Mexico
Hepatic lipid metabolism is altered in Ubiad1+/− mice of both sexes
Impact of asthma control on quality of life among palestinian children
Abstract Asthma is a chronic respiratory disease that significantly affects children, impacting their health-related quality of life. This study aimed to explore the relationship between asthma control and quality of life among pediatric asthma patients in the West Bank, Palestine. A descriptive, cross-sectional study was conducted among 220 pediatric patients with asthma and their mothers, recruited from four governmental hospitals. Data were collected using self-administered questionnaires that included demographic information, an asthma control test, and the Pediatric Asthma Quality of Life questionnaire. The final analysis included 182 children with a mean age of 8 years. The results showed that 71.9% of the children had uncontrolled asthma, with poor health-related quality of life reported by approximately 70% of this group. In contrast, only 2.7% of children with controlled asthma reported reduced quality of life. The findings indicate a strong association between asthma control and health-related quality of life. Healthcare policies should prioritize educational programs for children and their parents to improve asthma management and overall well-being.
The underlying mechanisms of family function on anxiety among nurses during the public health emergency
Transcriptomic neuron types vary topographically in function and morphology
Abstract Neuronal phenotypic traits such as morphology, connectivity and function are dictated, to a large extent, by a specific combination of differentially expressed genes. Clusters of neurons in transcriptomic space correspond to distinct cell types and in some cases—for example, Caenorhabditis elegans neurons1 and retinal ganglion cells2–4—have been shown to share morphology and function. The zebrafish optic tectum is composed of a spatial array of neurons that transforms visual inputs into motor outputs. Although the visuotopic map is continuous, subregions of the tectum are functionally specialized5,6. Here, to uncover the cell-type architecture of the tectum, we transcriptionally profiled its neurons, revealing more than 60 cell types that are organized in distinct anatomical layers. We measured the visual responses of thousands of tectal neurons by two-photon calcium imaging and matched them with their transcriptional profiles. Furthermore, we characterized the morphologies of transcriptionally identified neurons using specific transgenic lines. Notably, we found that neurons that are transcriptionally similar can diverge in shape, connectivity and visual responses. Incorporating the spatial coordinates of neurons within the tectal volume revealed functionally and morphologically defined anatomical subclusters within individual transcriptomic clusters. Our findings demonstrate that extrinsic, position-dependent factors expand the phenotypic repertoire of genetically similar neurons.
An innovative approach to studying the physical, mechanical, and antimicrobial properties of propylene film using Allium sativum skin, AgNO3, and corn Zein encapsulation (AACE)
Assessing climate change risk and vulnerability among Bhil and Bhilala tribal communities in Madhya Pradesh, India: a multidimensional approach
A retrospective study of radiotherapy combined with immunotherapy for patients with baseline brain metastases from non-small cell lung cancer
Global burden of MAFLD, MAFLD related cirrhosis and MASH related liver cancer from 1990 to 2021
A novel hierarchical control strategy for enhancing stability of a DC microgrid feeding a constant power load
Study on the change rule of airflow temperature field in ultra-deep mining shaft
The correlation between age, blood pressure variability and estimated pulse wave velocity
Proteomic insights into survival strategies of Escherichia coli in perchlorate-rich Martian brines
Abstract Brines, potentially formed by the deliquescence and freezing point depression of highly hygroscopic salts, such as perchlorates (ClO 4 − ), may allow for the spatial and temporal stability of liquid water on present-day Mars. It is therefore of great interest to explore the microbial habitability of Martian brines, for which our current understanding is, however, still limited. Putative microbes growing in the perchlorate-rich Martian regolith may be harmed due to the induction of various stressors including osmotic, chaotropic, and oxidative stress. We adapted the model organism Escherichia coli to increasing sodium perchlorate concentrations and used a proteomic approach to characterize the adaptive phenotype. Separately, the microbe was adapted to elevated concentrations of sodium chloride and glycerol, which enabled us to distinguish perchlorate-specific adaptation mechanisms from those in response to osmotic, ion and water activity stress. We found that the perchlorate-specific stress response focused on pathways alleviating damage to nucleic acids, presumably caused by increased chaotropic and/or oxidative stress. The significant enrichments that have been found include DNA repair, RNA methylation and de novo inosine monophosphate (IMP) biosynthesis. Our study provides insights into the adaptive mechanisms necessary for microorganisms to survive under perchlorate stress, with implications for understanding the habitability of Martian brines.