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Trends in hemoglobin-to- red cell distribution width ratio and its prognostic value for all-cause, cancer, and cardiovascular mortality: a nationwide cohort study

Scientific Reports Tianjie Lai, Yiyin Liang, Fenglei Guan et al. Mar 05, 2025 DOI: 10.1038/s41598-025-92228-w

Attention dual transformer with adaptive temporal convolutional for diabetic retinopathy detection

Scientific Reports Mishmala Sushith, Ajanthaa Lakkshmanan, M. Saravanan et al. Mar 05, 2025 DOI: 10.1038/s41598-025-92510-x

Impact of behavioral differences on white-lipped peccary reintroduction success in the Atlantic forest

Scientific Reports Cid J. T. Cavalcante Neto, Sérgio L.G. Nogueira-Filho, André L. G. Nogueira et al. Mar 05, 2025 DOI: 10.1038/s41598-025-90853-z

The Resilience on Amphetamine Relapse Youth Scale: development and psychometric properties

Scientific Reports Penpaktr Uthis, Ifa Hafifah, Sunisa Suktrakul et al. Mar 05, 2025 DOI: 10.1038/s41598-025-90294-8

Integrating transcriptomic data with a novel drug efficacy prediction model for TCM active compound discovery

Scientific Reports Yingcan Li, Yu Shen, Yezi Cai et al. Mar 05, 2025 DOI: 10.1038/s41598-024-82498-1

A blockchain-integrated chaotic fractal encryption scheme for secure medical imaging in industrial IoT settings

Scientific Reports Saba Inam, Shamsa Kanwal, Mamoona Batool et al. Mar 05, 2025 DOI: 10.1038/s41598-025-89604-x

Trends in the global, regional, and national burden of bladder cancer from 1990 to 2021: an observational study from the global burden of disease study 2021

Scientific Reports Xingyang Su, Yifang Tao, Feng Chen et al. Mar 05, 2025 DOI: 10.1038/s41598-025-92033-5

Pharmacovigilance analysis of immune checkpoint inhibitor-related reproductive adverse effects based on the FDA adverse event reporting system

Scientific Reports Bahadır Köylü, Buğra Han Esen, Şevval Nur Bektaş et al. Mar 05, 2025 DOI: 10.1038/s41598-025-91476-0

Effects of childhood maltreatment on mothers’ empathy and parenting styles in intergenerational transmission

Scientific Reports Yuko Kawaguchi, Sawa Kurata, Natasha Y. S. Kawata et al. Mar 05, 2025 DOI: 10.1038/s41598-025-92804-0

Using Masao facial makeup in software interface interaction design from the perspective of digital communication

Scientific Reports Jinxia Wang Mar 05, 2025 DOI: 10.1038/s41598-025-90448-8

Abstract Masao facial makeup, a unique folk cultural form from the Baoji region, carries a rich traditional heritage. However, its inheritance and development have long been hindered by limited dissemination channels and insufficient public attention. This paper proposes an innovative model for deeply integrating Masao facial makeup with computer software, and transforming it into an interactive filter within social media applications. This unique design not only fills the gap in the digital representation of Masao facial makeup but also takes a crucial step in combining folk culture with modern technology. Through a systematic survey, this paper comprehensively collects and precisely analyzes user expectations for functionality and suggestions for improvements regarding the Masao Facial Makeup APP. Based on this, the paper develops a functional system that aligns with user needs. The art essence of Masao facial makeup is then cleverly incorporated into the app’s innovative interface design. A group of 50 representative volunteers are selected to undergo a strict feasibility test of the app, and the APP is then compared to two mainstream traditional cultural apps on the market. The results show that the Masao Facial Makeup APP demonstrates significant advantages. This APP far surpasses the control group in core dimensions such as visual effects, functional attributes, interactive experience, and operational experience, with scores of 4.2, 4.9, 4.5, and 4.6, respectively. During the testing process, volunteers highly praise the app’s interactive interface design and fully recognize the smoothness and convenience of its operation. The key research contribution lies in successfully establishing a new paradigm for the cultural inheritance of Masao facial makeup. By leveraging digital tools, it significantly enhances its dissemination effectiveness and cultural influence, providing an innovative template and practical path for the protection and inheritance of similar folk cultures. This paper strongly promotes the innovative development and sustainable inheritance of folk culture in the digital age and holds the potential to revitalize more cultural treasures with the support of modern technology. It enriches the cultural inheritance ecosystem, and expands the boundaries and possibilities of cultural transmission.

The LncRNA lnc-POTEM-4:14 promotes HCC progression by interacting with FOXK1

Scientific Reports Bo Peng, Zhipeng Quan, Lixing Liang et al. Mar 05, 2025 DOI: 10.1038/s41598-025-92614-4

Evolution of irreversible differentiation under stage-dependent cell differentiation

Scientific Reports Yuanxiao Gao, Yuriy Pichugin, Arne Traulsen et al. Mar 05, 2025 DOI: 10.1038/s41598-025-91838-8

Responses of the carotid artery to acute, fractionated or chronic ionizing irradiation, and differences from the aorta

Scientific Reports Nobuyuki Hamada, Ki-ichiro Kawano, Seiko Hirota et al. Mar 05, 2025 DOI: 10.1038/s41598-025-92710-5

Abstract The circulatory system receives ionizing radiation at various dose rates. Given mounting epidemiological evidence of elevated radiation risks for diseases of the circulatory system (DCS), the International Commission on Radiological Protection recently recommended the first ever dose threshold for DCS. However, very little knowledge exists about whether radiation effects differ with dose rates and among tissues of the circulatory system. Here, we investigated the impact of dose rates in the carotid artery (CA) and compared it with the aorta. CA was obtained from mice irradiated with the same total dose that was delivered either acutely, 25 fractions, 100 fractions or chronically. CA underwent immunofluorescence and histochemistry staining. Irradiation led to vascular damage, inflammation and fibrosis in CA. The integrative analysis for 14 prelesional endpoints revealed that the magnitude of carotid changes was greater in 25 fractions, smaller in 100 fractions, and much smaller in chronic irradiation, compared with acute irradiation. Radiation responses of the aorta were qualitatively similar to, but quantitatively greater than those of CA. Irradiation causes sparing and enhancing dose protraction effects in a manner that is not a simple function of dose rate, and that radiosensitivity varies within the circulatory system.

Potential geological risks from mud diatremes in the orogen regime of Southwestern Taiwan

Scientific Reports Hung-Yu Wu, Hou-Chun Liu, Li-Cheng Kao et al. Mar 05, 2025 DOI: 10.1038/s41598-025-91915-y

Prospective association of daily toothbrushing frequency and the prevalence of childhood functional constipation: the Japan Environment and Children’s Study

Scientific Reports Masahiro Tsuchiya, Shinobu Tsuchiya, Haruki Momma et al. Mar 05, 2025 DOI: 10.1038/s41598-025-88562-8

Abstract Functional constipation is the most common gastrointestinal disorder during childhood. Oral stimulation (mastication and toothbrushing) reportedly improves bowel movements, but the association between daily toothbrushing behavior and functional constipation remains unknown. Data (n = 83,660) from fetal records (n = 104,059) in the Japan Environment and Children’s Study, an ongoing prospective birth cohort, were analyzed to investigate the impact of daily toothbrushing frequency on functional constipation during childhood, using ROME III diagnostic criteria. After multiple imputations of data acquired from self-reported questionnaires, a multivariable binomial logistic regression analysis was used with adjustments for several maternal and child-related variables. Functional constipation was observed in 10,123 (12.1%) and 8,820 (10.5%) participants at 3 and 4 years postpartum, respectively. Using the appropriate frequency of daily toothbrushing (twice or more) as a reference, the odds of functional constipation increased with decreasing daily toothbrushing frequency after covariate adjustments involving daily feeding frequency. The adjusted odds ratio (OR) for functional constipation in participants without daily toothbrushing behavior (less than once a day) at 4 years postpartum was 1.87 (95% confidence interval [CI] 1.34–2.61). Similarly, the adjusted OR (95% CI) for chronic functional constipation (at both 3 and 4 years postpartum) in participants without daily toothbrushing behavior (less than once a day) at 2 years postpartum was 1.62 (1.14–2.31). Functional constipation during childhood was associated with decreased daily toothbrushing frequency. Although the underlying mechanism of daily toothbrushing behavior in prompting bowel movements remains unclear, it is a major basis of self-health management in children that plays an important role in managing functional constipation.

Development and validation of automated three-dimensional convolutional neural network model for acute appendicitis diagnosis

Scientific Reports Minsung Kim, Taeyong Park, Jaewoong Kang et al. Mar 05, 2025 DOI: 10.1038/s41598-024-84348-6

Whole-body cryotherapy can reduce the inflammatory response in humans: a meta-analysis based on 11 randomized controlled trials

Scientific Reports Jun He, Xinyu Zhang, Zhili Ge et al. Mar 05, 2025 DOI: 10.1038/s41598-025-90396-3

Multiband THz MIMO antenna with regression machine learning techniques for isolation prediction in IoT applications

Scientific Reports Md Ashraful Haque, Kamal Hossain Nahin, Jamal Hossain Nirob et al. Mar 05, 2025 DOI: 10.1038/s41598-025-89962-6

Reporting of physical activity levels in intensive care unit survivors

Scientific Reports Sakshi Surve, Mukesh Kumar Sinha, Vishal Shanbhag et al. Mar 05, 2025 DOI: 10.1038/s41598-024-83262-1

Abstract The primary aim of this study was to report the physical activity profiles and the functional status of critically ill patients at one-month post-discharge using the ‘Physical Activity Scale for the Elderly (PASE)’ questionnaire. Study participants included were between 45 and 75 years of age, admitted to ICUs for a minimum of 24 h. Altogether, 110 study participants were included by consecutive sampling, from which six were lost to follow up. This prospective observational study was carried out in the ICU settings of Kasturba Hospital, Manipal. All the participants were assessed for ICU-acquired weakness at ICU discharge and were later followed up after one month for their physical activity level via telephonic follow-up. Participants’ mean age was 57.5 ± 9.82 years, out of which 71% were female. The prevalence of ICU-acquired weakness was found to be 80% in these participants. The median PASE score was 5 (2–27) at one-month follow-up among the participants. Medical Research Council (MRC) sum score showed a statistically significant positive moderate association with PASE score (‘r = 0.70, p < 0.05). The study showed that about 97.1% of ICU survivors lead a sedentary lifestyle and showed alarmingly high levels of physical inactivity at one month post-hospital discharge.

Cost-effectiveness of HIV pre-exposure prophylaxis among female sex workers in Iran

Scientific Reports Hossein Moameri, Reza Goudarzi, Ali Akbar Haghdoost et al. Mar 05, 2025 DOI: 10.1038/s41598-025-92099-1