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Role of trans-resveratrol in ameliorating biochemical and molecular alterations in obese rats induced by a high fructose/fat diet
Abstract We evaluated the effect of trans-resveratrol (RSV) in ameliorating biochemical and molecular alterations in obese Wister male rats fed on high-fat/high-fructose-fed. Male Wister rats were divided into eight groups and fed with either a standard diet (control), high fructose (HF), high fat (HFAT), or a high- fructose high- fat (HF/HFAT) diet and supplemented with RSV (30 mg/kg/day) for 4 weeks. The food intake, body weight, glycemic parameters, lipid profile, oxidative stress were assessed. SIRT1 gene expression, PGC-1α, cyto-c and GLUT-4 were evaluated by qRT-PCR in adipose tissue of normal and obese rats. The body weight gain, serum fasting glucose, insulin, and HOMA-IR values were significantly higher in the HF and HF/HFAT groups than in the HFAT and control groups. Hyperlipidemia was observed in high calorie diets fed rats compared to control group. The levels of total cholesterol, triglycerides and LDL-c were significantly elevated while HDL- c was significantly decreased in HF & HF/HFAT groups compared to HFAT group. The levels of serum malondialdhyde (MDA) and superoxide dismutase (SOD) activity in adipose tissue were elevated in all groups compared to control group, particularly in the groups that were kept on a high fructose diets (HF, HF/HFAT). SIRT-1, PGC-1α, Cyto-c, and GLUT-4 genes levels were significantly down regulated in HF, HFAT & HF/HFAT groups compared to control group. Supplementation of T-RSV restored the alteration in carbohydrates-lipid metabolism as well as oxidative stress and upregulation of SIRT-1, PGC-1α, Cyto-c, and GLUT-4 genes. RSV is a promising treatment in the management of pathologic consequences of obesity from high-calorie diet consumption via molecular alteration of target genes.
Seasonal thermal performance of double and triple glazed windows with effects of window opening area
Effect of Hoagland’s nutrient solution strengths and sodium silicate on growth, yield and biochemical parameters of Carla (Momordica Charantia L.) under hydroponic conditions
Abstract The medicinal species of Carla (Momoradica charantia) is one of the medicinal plants in Cucurbitaceae family, which has shown significant effects on the control of diabetes, blood pressure, high cholesterol and liver failure due to its valuable alkaloid and glycosidic compounds. In order to investigate the effect of different strengths of Hoagland’s nutrient solution and different levels of sodium silicate on yield components, biochemical characteristics and photosynthetic pigments of the medicinal plant Carla under hydroponic conditions, a factorial experiment in the form of a completely randomized design with three replications was carried out in the Department of Medicinal Plants of Arak University. The first factor included the concentrations of nutrient solution at four levels (¼, ½, 1 and 2 strength of Hoagland’s nutrient solution) and the second factor included sodium silicate spraying at four levels (0, 50, 100 and 150 mg L− 1) taken from the source of sodium silicate. The results showed that different strengths of Hoagland’s nutrient solution and different concentrations of sodium silicate had a significant effect on all growth and morphological traits. The results of the experiment showed an increase in the number of flowers and fruits in double strength Hoagland concentration compared to the control (full strength), and the lowest amounts of these traits were observed at ¼ strength Hoagland concentration. In addition, the maximum numbers of flowers and fruit, fruit diameter, fruit length, and fruit weight were obtained at concentration of 100 mg L− 1 sodium silicate, and the minimum values of these traits were recorded at ¼ strength Hoagland’s solution. The highest amounts of chlorophyll b and a were seen in double strength Hoagland’s solution and the lowest amounts were seen in ¼ strength Hoagland. Moreover, the amount of carotenoid was the highest in ¼ strength Hoagland and the lowest in double strength Hoagland. The maximum and minimum values of chlorophyll b and a were obtained at concentrations of 150 and 0 mg/kg sodium silicate, respectively. In general, it was found that double strength Hoagland was more effective than other concentrations on yield components and morphological parameters, and flowering and fruit harvesting times were also reduced in the mentioned treatment. On the other hand, sodium silicate at 100 and 150 mg L− 1 had more obvious effects on the evaluated traits and the reduction of flowering and fruit harvesting times.
Potential of MSCA1 for isolating osteogenic cells in a chondrocyte population
Facing Political Attacks on Medical Education — The Future of Diversity, Equity, and Inclusion in Medicine
Smart EV charging via advanced ongrid MPPT-PV systems with quadratic-boost split-source inverters
Abstract This paper presents an enhanced Maximum Power Point Tracking (MPPT) algorithm for Quadratic-Boost Split Source Inverters (QB-SSI), designed for grid-connected Photovoltaic (PV)-powered smart charging stations for Electric Vehicles (EVs). The proposed algorithm integrates advanced control strategies and adaptive techniques to address the limitations of traditional MPPT techniques. By dynamically adjusting to operating conditions and environmental factors, the enhanced algorithm achieves accurate and rapid tracking of the maximum power point (MPP) under dynamic conditions. The paper provides a comprehensive overview of the QB-SSI topology, a detailed mathematical model, and simulation results. These findings demonstrate the superior performance of the enhanced MPPT algorithm, offering significant improvements in tracking accuracy, convergence time, and efficiency, thereby enhancing the overall performance of QB-SSI-based PV systems. A modified space vector modulation (SVPWM) is utilized to enhance the inverter switching characteristics and dc-boosting capability. The overall system is modeled via MATLAB/Simulink™, and the experimental results providing valuable insights into the performance and functionality of the proposed algorithm. This allows for a comprehensive analysis of its capabilities and potential advantages in practical applications.