Browse Articles

Spatio temporal association between sterile and wild males in a Ceratitis capitata SIT programme

An Adaptive Palladium Single-Atom Catalyst Enabling Reactivity Switching between Borylation and C–C Coupling

Ammonia sets limit to life and alters physiology independently of pH in Halomonas meridiana

Abstract The subsurface oceans of icy moons, expected to retain appreciable concentrations of ammonia, are of significant interest to astrobiology. On Earth, ammonia is released in large quantities, primarily through anthropogenic activities. Ammonia is toxic to many forms of life at high concentrations, and thus it is necessary to understand the habitability impact of ammonia on these environments. The survival limits and physiological response of aerobic bacteria in ammonia, and whether ammonia toxicity is distinct from toxicity by high pH, is poorly understood. Here, we investigate the survival thresholds, growth kinetics, and metabolomic response of Halomonas meridiana in ammonia-water solutions and pH-matched sodium hydroxide solutions. Using closed- and open-air systems to mimic environments with NH 3 retention or dispersion, we found complete and partial cell death above 0.05 M ammonia, respectively. In open-air systems, a sub-set of cells survived up to 0.25 M ammonia; metabolomics revealed unique physiological responses to ammonia, including elevation of cyclic compounds and Coenzyme A metabolites, suggesting mechanisms of ammonia toxicity and adaptation. Ammonia and high pH toxicity were found to be distinct. These findings show that ammonia can impose a distinct geobiological limit, potentially constraining the habitability of ammonia-rich terrestrial and extraterrestrial environments.

Toward Chiral Recognition by Design: Uncovering the Self-Enantioresolving Properties of Chiral Amine Derivatives

Rethinking VLMs and LLMs for image classification

Responsive Organoselenium Dendritic Polymers: From Monodisperse Dendrimers to Self-Assembled Micelles for Advanced Therapeutic Applications

Clinicopathological features and mucin expression of early papillary gastric adenocarcinoma

<i>Bis</i>-Allylic Deuterated Docosahexaenoic Acid-Esterified Phospholipids Resist In Vivo Peroxidation in Rat Brain

Remaining useful life prediction method of centrifugal pump rolling bearings based on digital twins

Caught in the Middle: A Rigid DNA Label That Provides an Incisive Picture of DNA Conformational Flexibility in Protein–DNA Complexes

Electroconvulsive therapy improves distal colonic motility via the subdiaphragmatic vagus nerve in depressive-like mice

Guanine Crystallization by Particle Attachment

A preliminary study on farmed and free-ranging mouflons core microbiome

The Critical Role of Chemistry in Advancing Quantum Information Science

Academic help seeking behavior as a mediator of the relationship between social skill and mathematics achievement among primary school students

Abstract This study aimed to examine the mediating role of students’ academic help-seeking behavior in explaining the relationship between students’ social skills as motivational orientation and mathematics achievement among primary schools of Grade 8 students. Data were collected from 930 students among nine primary schools at the Dessie city administration in Ethiopia. The participant students were selected using systematic random sampling technique among selected schools. In line with the research objective, the research used correlational design in order to explain the relationship among variables. SPSS 24.0 and Smart PLS 4 were used for data analysis. The result of this study shows a significant direct positive effect of social skill on academic help-seeking behavior and mathematics achievement. Moreover, academic help-seeking behavior demonstrates a direct positive effect on mathematics achievement and plays a partial mediating role in the relationship between social skill and mathematics achievement. Thus, the findings indicated that the students’ academic help-seeking behaviors are part of the mechanism through which social skill affects students’ mathematics achievement. Accordingly, the research suggests the importance of comprehensive interventions to enhance students’ academic achievement.

High-Curvature Interfaces Induce Nondegenerate Splitting of <i>d</i>-Orbital Energy Levels for Enhanced Catalytic Activity

Geostress in the Ordovician system of the northern segment of the Shunbei No. 4 fault zone based on finite element simulation

Abstract The principal focus of geostress studies in the Shunbei area has been on stress measurements, one-dimensional stress profiles, and the stress distribution across planes. However, research on the three-dimensional (3-D) geostress field of the Ordovician system is relatively lacking, and investigations into the stress states of faults have not yet been conducted, thereby hindering the progress of oil and gas exploration and development in this area. This article comprehensively utilizes geological, logging, and seismic data to establish a high-resolution 3-D structural geological model. Based on the results of rock mechanics tests on core samples, acoustic logging data, and 3-D pre-stack inversion datasets, a rock mechanics model for the study area is constructed. In addition, employing finite element simulation methods, the present-day geostress field of the Ordovician system in the study area is numerically simulated, thereby establishing the 3-D geostress field and elucidating the distribution characteristics of the Ordovician system’s geostresses. It systematically analyzes the stress state and activity of the strike-slip faults, highlighting their impact on drilling productivity. Our results provide a basis for the selection of drilling targets and well site deployment. The results lay a foundation for deepening the understanding of the interaction mechanisms between the geological structures and underground stress fields, guiding petroleum resource development, and promoting related geological scientific research in the Ordovician system or geostress mechanics.

A Solvatochromic Near Infrared Fluorophore Sensitive to the Full Amyloid Beta Aggregation Pathway

Network pharmacology-based study in polymetformin’s new function of blocking ages/rage pathway curing diabetic complications

Impact of a psychoeducational nursing program on self-efficacy and psychological adjustment in hemodialysis patients

Abstract Self-efficacy and psychological adjustment to illness are crucial for new hemodialysis patients as they empower individuals to manage their treatment effectively and cope with the emotional and physical challenges of their condition. Research on the psychological aspects of hemodialysis patients in the Middle East is limited, and even rarer are interventions specifically tailored to promote them. This study evaluates the impact of a psychoeducational nursing program on self-efficacy and psychological adjustment among hemodialysis patients. A quasi-experimental design was utilized with a purposive sample of 53 patients aged 18–60 years, undergoing hemodialysis for less than a year at NIUN, Cairo, Egypt. Data were collected using a socio-demographic and clinical data questionnaire, Self-Efficacy for Hemodialysis Scale, and Psychological Adjustment to Illness Scale. Our program, which specifically targeted new hemodialysis patients, aimed to facilitate faster and more effective psychological adaptation through interactive discussions, practical coping strategies, and educational materials on disease management and self-care. Our study showed improvement in self-efficacy for hemodialysis patients in pre- and post-program implementation, with a p-value of (0.057), and a highly significant improvement in psychological adjustment to illness, with a p-value of (0.001). Based on the improvements observed, psychoeducational programs should be integrated into standard care for new hemodialysis patients, with a focus on multidisciplinary collaboration to address both medical and psychological needs.