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Underwater kelp forests are losing a turf war
Crosstalk between delayed and immediate subjective evaluation tasks
Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting
Abstract Making early and informative diagnoses of mild cognitive impairment (MCI) is highly important for planning timely and appropriate interventions aimed at dementia risk reduction. However, there is currently no agreement on the MCI criteria, leading to wide heterogeneity in the prognosis of MCI patients and high reversion rates. Our study aimed to compare the prognostic value of Conventional (Petersen/Winblad) and Neuropsychological (Jak/Bondi) criteria for the diagnosis of MCI. We directly compared the ability of each classification method to predict progression to dementia and the stability of the diagnosis over 12 years in a population-based sample of 1021 older adults without dementia. The relative impact of subjective complaints and objective impairment on clinical progression was further evaluated. Baseline MCI diagnosis with the Neuropsychological and Conventional criteria was associated with a comparable risk of dementia over time. Across the study period, the Neuropsychological criteria led to more consistent diagnoses (63.2% vs. 43.2%). The copresence of subjective memory complaints and objective impairment at baseline was associated with increased dementia risk within both diagnostic frameworks. These results further support the use of comprehensive neuropsychological assessment to make timely and appropriate MCI diagnoses and show the added prognostic value of subjective complaints.
Machine learning-based integration develops relapse related signature for predicting prognosis and indicating immune microenvironment infiltration in breast cancer
Dysbiosis of gut microbiota with enriched pro-inflammatory species in children with idiopathic short stature: a case-control study
GCMS analysis and acaricidal activity of Ailanthus altissima extract against cattle tick Rhipicephalus (Boophilus) microplus and Hyalomma anatolicum: in vitro and in silico approach
US–China tariff war threatens global public health
Development and application of advanced learning models for predicting the land subsidence due to coal mining
Gender equality in research publishing is a responsibility for everyone
Public security patrol path planning recommendation method based on wolf-pack optimization algorithm using DAF and BRS
Design and synthesis of 3,4-seco-lupane triterpene-tryptamine derivatives and revealing their anti-bladder cancer mechanisms by combining TCGA and transcriptomic approaches
Abstract Bladder cancer is the most common malignant tumor of the urinary tract. In this study, 90 lupane triterpene derivatives, previously synthesized in the laboratory, were systematically evaluated for their potential effects against bladder cancer by cytotoxicity screening against five urinary tumor cell lines. Bioinformatics and molecular dynamics methods were used to investigate the mechanism of action of compound 27 in depth. Most of the derivatives effectively inhibited tumor cell growth, and structure–activity relationship analysis revealed that introducing an indole moiety significantly enhanced the biological activity. The peak activity was reached when the dibromoalkyl chain length was C = 5 (IC50 = 1.121 μM). By integrating transcriptomic data and TCGA findings, we identified 11 key targets, among which DUSP5 and SCG2 showed significant differential expression. Further analysis revealed meaningful insights into the clinical association, 10-year survival prognosis, and immune infiltration. The present study further clarified the effects of compound 27 on the expression of DUSP5 and SCG2 in tumor cells after treatment by a combination of RNA-seq and RT-qPCR. Molecular docking confirmed the stable binding of compound 27 to DUSP5, which was confirmed by molecular dynamics simulations. Compound 27 inhibited bladder cancer progression by upregulating DUSP5 expression and negatively regulating the p38 MAPK pathway, modulating the immune response and promoting apoptosis.