Browse Articles

Drug induced liver injury in HIV patients on dolutegravir based antiretroviral therapy regimens in Wolaita Sodo comprehensive specialized hospital

Opening the Door to Tailored Treatment in Newly Diagnosed Multiple Myeloma

Design and analysis of a power transmission system for 55 kW electric tractor using agricultural workload data

Case 22-2025: A 19-Year-Old Woman with Seizurelike Activity and Odd Behaviors

Change of venue: fission-yeast cell-division cues actually initiate in the nucleus

Potent antimicrobial and antibiofilm activity of citric acid coated magnetite nanoparticles for leather preservation

Measurable Residual Disease–Guided Therapy in Newly Diagnosed Myeloma

The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner

Advances in Preventing Transmission of Mitochondrial DNA Diseases

A novel flexible identity-net with diffusion models for painting-style generation

Into the Valley of the Sick

Image stitching for real-time laparoscopic hyperspectral imaging

Abstract Hyperspectral imaging (HSI) shows significant promise in the medical field for tissue detection and perfusion assessment. To extend its application to intraoperative diagnosis, laparoscopic cameras combining a high resolution color video and simultaneous HSI were developed. Spatial scanning in these cameras is performed through a push-broom motor driving a line-scan spectrograph. However, long acquisition times and the necessity of absolute immobility for patient and operator currently limit its usability in the operating room. To provide a hyperspectral acquisition alternative to the traditional push-broom motor approach, we have developed an HSI stitching pipeline that enables freehand line scanning. Our method utilizes the dual recording capability of the camera, which has both an RGB and an HSI sensor. It applies the transformations observed in the RGB video to the corresponding HSI data, then seamlessly merges this data to create a coherent panorama. This allows operators to visualize hyperspectral data as an incrementally expanding overlay on the color video by scanning the scene with the laparoscope. The pipeline evaluation confirms the generation of globally consistent and well-interpretable panoramas with a high level of detail. The registration error is not only comparable to the push-broom method but also corresponds to a real-world error of less than 0.4 mm in 95 % of the cases. Therefore, the proposed method enhances the practicability of intraoperative hyperspectral imaging by providing a dynamic, video-like experience of HSI visualizations.

Reducing the Risks of Mitochondrial Disease in Children

RNA codon expansion via programmable pseudouridine editing and decoding

Application of an improved pelican optimization algorithm based on comprehensive strategy in PV parameter identification

Phase 2a Study of Baxdrostat in Primary Aldosteronism

Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson’s disease

Impact of agricultural industry transformation based on deep learning model evaluation and metaheuristic algorithms under dual carbon strategy

Design, antiproliferative potency, and in silico studies of novel 5-methylfuran-3-yl)thio)-3-phenylquinazolin-4(3H)-one based derivatives as potential EGFR inhibitors

Abstract Quinazolinone derivatives have been broadly studied as anti-cancer drug candidates due to their potential to inhibit key signaling pathways involved in tumor progression. In the current study, new 2-[(4-substituted-5-methylfuran-3-yl)thio]-3-phenylquinazolin-4(3H)-one derivatives (2–10) were designed and assessed for anti-cancer activity. Cytotoxicity of the compounds was tested against normal WI-38 cells and cancer cell lines HepG-2 (liver), MCF-7 (breast), and HCT-116 (colorectal). In addition, their inhibitory effects on EGFR and VEGFR-2, key targets for tumor growth and angiogenesis, were assessed. Compounds 6b and 10 showed significant cytotoxic activity, with 6b (IC₅₀ = 0.19 ± 0.03 μM) being the most effective EGFR inhibitor, over 10 (IC₅₀ = 0.51 ± 0.04 μM) and as potent as erlotinib (IC₅₀ = 0.23 ± 0.02 μM). Flow cytometry revealed that 6b induced apoptosis in 35.29% of MCF-7 cells and G₂/M phase cell cycle arrest, much better than that of untreated cells (6.81%). In silico ADMET prediction and molecular docking confirmed high EGFR binding affinity and favorable pharmacokinetic properties. Overall, compound 6b showed promising anti-cancer activity via EGFR inhibition, apoptosis, and cell cycle arrest and is a good lead for further development as an EGFR-targeted agent.

A novel dynamic scheduling model for application in multimode approach