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A burden of proof study of the effects of exposure to high fasting plasma glucose on the risk of seven types of cancer
Abstract Cancer is a major public health problem strongly influenced by genetic factors and aging; however, a proportion of its burden can be attributed to potentially modifiable risk factors. We undertook a systematic review and meta-analysis of the existing evidence to quantify and assess the relationship between high fasting plasma glucose (FPG) levels and the risk of developing and dying for seven types of cancer (selected for having attributable burden from FPG in GBD). Using Burden of Proof methods that provide a conservative interpretation of the evidence, we found moderate relationships between high FPG and the risk of breast, pancreatic, and colorectal cancer. Weak relationships were observed with bladder, liver, ovarian, and tracheal, bronchus and lung cancers. These findings should galvanize the global community’s efforts in addressing the increasing burden of high blood sugar and inform the potential impact of different hypoglycemic treatments on reducing the burden of cancer.
Magneto-hydrodynamic behavior of magnetic nanofluids in mini-channel heat sinks for electronics cooling
A fiber-optic traffic monitoring network trained with video inputs
DeepMind and OpenAI models solve maths problems at level of top students
Leveraging multimodal large language model for multimodal sequential recommendation
A single-blind active-control randomized controlled trial of group-based social competence intervention
Phenotype augmentation using generative AI for isocitrate dehydrogenase mutation prediction in glioma
Evaluation of how laser photostimulation at two wavelengths alters the antimicrobial potential of Streptomycetes spp
Metabolic profile changes in patients with rheumatoid arthritis detected using mass spectrometry
Residual strength of granitic rocks: interplay between GSI and confining pressure
Abstract Residual strength is an important factor in rock mechanics and geotechnical engineering, referring to the remaining strength of rocks following considerable deformation or damage. This study investigates the post-failure behavior of granitic rock samples from Bátaapáti, Hungary, using multiple failure triaxial testing and residual strength models. Experimental results show that residual strength is significantly influenced by confining pressure, with values increasing as confinement rises. Key models, including the Hoek-Brown failure criterion, Geological Strength Index (GSI), Residual Strength Index (RSI), and Cohesion-Loss approaches, were evaluated for their ability to predict residual strength. Nonlinear regression of deviator stress versus confining pressure was found. Using this nonlinear model, the relationship between the residual GSI and the confining pressure could be determined. It was carried out that the increasing the confining pressure the residual GSI logarithmically increased. It means, the residual GSI is not a material constant.
Comprehensive in vitro and whole-genome characterization of probiotic properties in Pediococcus acidilactici P10 isolated from Iranian broiler chicken
Microbial signature of groundwater mixing in geothermal areas: insights from the Cimino-Vico volcanic system (central Italy)
Proactive care architecture for care robots
A coordinated cellular network regulates tolerance to food
Inspiratory muscle warm up improves 400 m performance in elite male runners
Abstract This study sought to establish an optimal inspiratory warm-up (IWU) protocol for elite 400-meter athletes. It addresses the existing gap in sprint-specific research and provides practical applications for coaches and athletes aiming to optimize sprint running performance. Across four weeks, 13 elite male runners (age: 22.7 ± 2, personal best: 50.78 ± 0.65 s) performed four 400-meter time trials after different warm-up protocols in a randomized order. Assessments of various respiratory variables [maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), peak inspiratory flow rate (PIFR), inhaled volume (IV)] and selected physiological indices [heart rate (HR) and blood lactate (bLa)] were performed before and after the time trials. Analysis of variance with a significance level of p < 0.05 was applied. Incorporating IWU into a standard running warm-up resulted in a ~ 0.38-second faster 400-meter time trial in elite male sprinters (p < 0.001). The most effective IWU protocols, associated with the fastest run splits, consist of two sets of 30 dynamic inspiratory maneuvers performed with pressure threshold loading at 40% or 60% of MIP resistance. These protocols exhibited a positive influence on selected respiratory indices and significantly lowered post-run lactate concentrations compared to the athletic warm-up and sham protocol. IWU with 40% MIP resistance was associated with lower post-run HR compared to other protocols. IWU using pressure threshold loading at either 40% or 60% of MIP can be beneficial for elite male sprinters. While 40% MIP appears to support faster recovery, a higher intensity at 60% MIP shows greater effectiveness in enhancing 400-meter sprint performance. Future research should explore IWU applications across broader populations and conditions, including female athletes, various hypoxic environments, and temperature variations.