Browse Articles

Case 24-2025: A 32-Year-Old Woman with Fatigue and Myalgias

Global warming reduces the carrying capacity of the tallest angiosperm species (Eucalyptus regnans)

Abstract Rising temperatures and increased frequency and intensity of droughts and heat waves have affected tree mortality rates worldwide. Here, we investigate how these changes have affected the carrying capacity of mountain ash forests (Eucalyptus regnans), the world’s tallest flowering plant and one of the most carbon-dense forests on earth. We analyze data from a large network of silvicultural experiments collected between 1947 and 2000 in southeastern Australia to identify trends in mortality rates and carrying capacity for the species, and to quantify how these changes relate to spatiotemporal variations in climate. We show that forests growing in the warmest and highest vapor pressure deficit conditions had the lowest carrying capacity, and this capacity further decreased with rising temperatures. Key findings indicate that a projected three °C increase in temperature by 2080 could reduce tree density and carbon stock in these forests by 24%, equivalent to losing 240,000 hectares of mature mountain ash forests. Trees that died were 0.62 times the size of living trees (i.e., they were suppressed), with no detectable effect of climate on this ratio. We discuss the implications for forest conservation and management, and how reduced carrying capacity could undermine global forest restoration and carbon sequestration efforts.

Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma

Machine learning-assisted Ru-N bond regulation for ammonia synthesis

Menopausal Symptom Management in Breast Cancer Survivors — A Promising New Option

Author Correction: Warning of a forthcoming collapse of the Atlantic meridional overturning circulation

Screening for Prostate Cancer with a Polygenic Risk Score

Species abundances surpass richness effects in the biodiversity-ecosystem function relationship across marine fishes

Abstract High biological diversity (or biodiversity) is thought to bolster communities against disturbances, leading to higher levels of ecosystem functioning. While the biodiversity-ecosystem function (BEF) relationship is evident in studies equating diversity to species richness, it is still unclear which ecological mechanisms can produce different observational BEF effects. Here, we combine 7686 individual growth curves across 1480 species with 2957 local community surveys to generate a process-based estimate of biomass production to assess the BEF relationship across marine reef fishes. We find that the effects of Hill diversity emphasising abundances outpace those of species richness and community evenness on biomass productivity. In high-latitude temperate regions, species abundances and richness have parallel effects on reef fish productivity. However, in the tropics, species abundances surpass species richness in their effects on functioning. These latitudinal disparities can be explained by trade-offs in the relationship between abundance and per-capita productivity. As whole-community productivity remains relatively stable across most of the diversity gradient, these trade-offs are presumably driven by metabolic constraints on growth and body size imposed by warmer temperatures. It appears that biodiversity can only support ecosystem functioning to a limited extent and environmental stressors likely limit the biomass production of marine fishes globally.

The Path Forward for Vaccine Policy in the United States

Early life high fructose impairs microglial phagocytosis and neurodevelopment

Finding spatially variable ligand-receptor interactions with functional support from downstream genes

Omitting Nodal Irradiation after Nodes Clear

Multi-scale and multi-context interpretable mapping of cell states across heterogeneous spatial samples

Abstract There is a growing demand for methods that can effectively align and compare spatial data in the absence of obvious visual correspondence. To address this challenge, we developed an interpretable cell mapping strategy based on solving a Linear Assignment Problem (LAP) where the total cost is computed by considering cells and their niches. We demonstrate that our approach outperforms other methods at capturing the spatial context of cells in synthetic and real data sets. The flexibility of our implementation enhances the interpretability of mapping and allows for accurate cell mapping across samples, technologies, resolutions, developmental and regenerative time. We show spatiotemporal decoupling of cells during development and patient level sub-populations in In Situ Mass Cytometry (IMC) cancer data sets. Our interpretable mapping approach facilitates systemic comparison and analysis of heterogeneous spatial data. We provide a flexible framework for researchers to tailor their analysis to the specific biological and research context.

Paraganglioma in the Organ of Zuckerkandl

Author Correction: Late Paleolithic whale bone tools reveal human and whale ecology in the Bay of Biscay

Preventive Care at the Supreme Court

Outrage over Trump team’s climate report spurs researchers to fight back

Single-shot readout of the nuclear spin of an on-surface atom

Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer

Visualizing acyl carrier protein interactions within a crosslinked type I polyketide synthase

Abstract Using a combination of dual covalent crosslinking and cryo-EM analyses, we elucidate the structure of mycocerosic acid synthase from Mycobacterium tuberculosis trapped in two distinct catalytic states during its iterative cycle. These structures reveal domain architecture of the acyl carrier protein mediating condensation and dehydration through dual site-selective crosslinking of the acyl carrier protein with the ketosynthase and dehydratase domains. Map density was sufficient to visualize full domain architecture with active site-bound probes and elucidate key interactions of four distinct crosslinked species. Here, iterative vectorial polyketide biosynthesis arises through an overall twisting and tilting architecture, enabling positioning and entry of the cognate substrate at each enzymatic domain. These structures present valuable details for future therapeutic design against mycocerosic acid biosynthesis in M. tuberculosis.