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Advancement in real time football analysis using fuzzy based decision-making of the WASPAS method
Outside Back Cover: Spin Frustration Determines the Stability and Reactivity of Metal–Organic Frameworks with Triangular Iron(III)–Oxo Clusters (Angew. Chem. Int. Ed. 41/2025)
A DFT study for volatile gas adsorption of surface modifications of carbon based fullerenes through mono doping and co doping
Combined antibacterial effect of essential oils from three Indian medicinal plants and antibiotic tetracycline on MRSA using simplex centroid mixture design
Predictors of chemotherapy-related unplanned acute care in outpatients receiving oral anticancer drugs
Abstract Severe adverse reactions to outpatient chemotherapy receiving oral anticancer drugs often lead to unplanned acute care (UAC) requirements, including unscheduled emergency visits and hospitalizations. These events result in treatment delay or interruption, which reduces the patients’ willingness to continue treatment and negatively impacts their quality of life. The aim of this study was to identify predictive factors for UAC, helping promote safer outpatient chemotherapy through early intervention. A retrospective case-control study was conducted with patients receiving outpatient chemotherapy with oral anticancer drugs at the National Cancer Center Hospital East between April 1, 2020, and March 31, 2021. Patients who experienced UAC were identified as cases, and matched controls were selected from those who did not experience UAC. Conditional multivariate logistic regression analysis was performed to estimate adjusted odds ratios and 95% confidence intervals to examine the association between risk factors and UAC onset. Among cytotoxic drug users, increased blood urea nitrogen concentration and decreased serum sodium concentration were identified as factors associated with increased UAC risk. In molecular-targeted drug users, increased blood creatinine concentration was associated with increased UAC risk. These findings may help optimize patient management and reduce UAC rates in outpatient chemotherapy settings.
The role of vitamin C in melanoma cell death via activation of cytochrome C and TNF-α protein expression
Abstract This study investigates the effect of vitamin C on cytochrome c and TNF-α expression, representing intrinsic and extrinsic apoptotic pathways in B16-F10 melanoma cells. B16-F10 melanoma cells (ATCC® CRL-6475™) were treated with vitamin C for 12 and 24 h. Expression of cytochrome c, TNF-α, caspase-3, and caspase-9 proteins was evaluated using in-cell western (ICW) assay. RT-qPCR was used to assess gene expression of Caspase-8, IL-6, PARP-γ, and TGF-β1. Morphological signs of cell death appeared within 12 h. A significant increase in cytochrome c expression at 3,000 µM concentrations of vitamin C was observed (p = 0.002), along with increases at 3,500 µM (p = 0.023), 4,000 µM (p = 0.0001), and 5,000 µM (p = 0.0001). Caspase-3 expression significantly increased at 3,000 µM (p = 0.012) and 5,000 µM (p = 0.048), while caspase-9 was not significant. TNF-α expression also increased significantly from 3,000 to 5,000 µM (all p < 0.01). Caspase-8 and PARP-γ mRNA levels were upregulated at 3,000 and 5,000 µM (p < 0.05). IL-6 and TGF-β1 changes further supported apoptosis activation. Vitamin C induces apoptosis in B16-F10 melanoma cells via intrinsic and extrinsic pathways, particularly at 3,000 and 5,000 µM concentrations, as shown by cytochrome c, TNF-α, and caspase-3 expression.
Solvent‐Driven Precise Control of Stacking Configurations in Covalent Organic Frameworks for High‐Efficiency Photocatalysis
AbstractTwo‐dimensional covalent organic frameworks (2D COFs) have emerged as promising photocatalysts due to their high surface areas and precisely tunable physicochemical properties. However, it remains a significant challenge to precisely control over interlayer stacking configurations in 2D COFs, which critically influence charge carrier transport and consequently determine catalytic efficiency. In this study, we demonstrate a solvent‐driven strategy to precisely regulate the interlayer stacking configurations of metal‐incorporated 2D COFs, successfully achieving both AA eclipsed (COF‐TD‐AA) and ABC staggered (COF‐TD‐ABC) configurations. Notably, by modulating the coordination interactions between solvent 1‐butanol and Zn2+ (within the COFs), the interactions between the Zn2+ and nitrogen atoms (from imine bonds, pyridine, and triazine units) can be precisely tuned, which leads to the formation of AA or ABC stacked 2D COFs. Interestingly, the ABC‐stacked COF‐TD‐ABC exhibited an extended light absorption and superior charge migration/separation efficiency than those of COF‐TD‐AA. As a result, when coupled with Pt co‐catalysts, COF‐TD‐ABC achieved a high hydrogen evolution rate up to 10.92 mmol g−1 h−1, representing a ∼3.5‐fold enhancement over COF‐TD‐AA (3.12 mmol g−1 h−1). This work provides a fundamental insight into the stacking‐dependent structure‐property relationships in COFs, paving the way for the rational design of high‐performance COF‐based photocatalysts.
Histone H4K16 acetylation modification regulated autophagy and apoptosis in neuron after spinal cord injury
DR-CoT: dynamic recursive chain of thought with meta reasoning for parameter efficient models
Abstract Chain-of-Thought (CoT) prompting has revolutionized reasoning in Large Language Models (LLMs), enabling them to tackle complex tasks by mimicking step-by-step human thought processes. However, traditional CoT methods often suffer from high computational costs and context dilution, limiting their effectiveness, particularly in resource-constrained or real-time applications. To address these challenges, we introduce Dynamic Recursive Chain-of-Thought (DR-CoT), a novel reasoning framework for parameter-efficient models. DR-CoT synergistically integrates recursive reasoning, dynamic context truncation, and a voting mechanism. By selectively retaining the most salient context within a fixed token budget and aggregating inferences from multiple independent reasoning chains, DR-CoT significantly enhances reasoning accuracy. Extensive evaluations on challenging reasoning benchmarks, including GPQA Diamond and AIME2024, demonstrate the efficacy of DR-CoT. On GPQA Diamond, DR-CoT sees Pass@1 accuracy gains of 1.5% for , 2.7% for Grok 3 Beta, and 4.4% for . Similarly, AIME2024 results reveal consistent improvements of 3-4 percentage points across evaluated models. Furthermore, DR-CoT enhances zero-shot classification performance on GPQA Diamond, enabling compact BERT-sized models to surpass larger language models such as and . In code generation tasks using HumanEval, DRCoT empowers models to exceed the performance of established frontier LLMs, including , , and . These comprehensive results underscore DR-CoT’s effectiveness in bridging the performance gap between parameter-efficient models and state-of-the-art LLMs across multiple domains.
Experimental and numerical simulation studies of the zwitterionic polymers for enhanced oil recovery
Outside Front Cover: Stereoselective Self‐Assembly of a Topologically Chiral [6]Catenane with 18 Crossings (Angew. Chem. Int. Ed. 41/2025)
Comparison of inflammatory and nutritional markers obtained at the time of diagnosis in patients diagnosed with renal cell carcinoma
Multi-experts decision support system for recycling of waste material using some circular pythagorean fuzzy Muirhead means
Photocatalytic Formamide Synthesis from Plastic Waste and Ammonia via C─N Bond Construction Under Mild Conditions
AbstractPhotocatalytic upcycling of polyethylene terephthalate (PET) waste into value‐added chemicals represents a sustainable route for plastic valorization. However, previous studies have solely focused on generating oxygenated compounds through intramolecular C─O bond transformations. Achieving heteroatom‐containing important chemicals via intermolecular coupling reactions is still challenging. Herein, we report the first example of the direct photocatalytic C─N coupling of PET‐derived ethylene glycol (EG) with ammonia to produce formamide (FA) and H2 over a Pt1Au/TiO2 catalyst. Pt1Au/TiO2 delivers a FA yield rate of ∼7.1 mmol gcat−1 h−1, as well as H2 evolution (∼22.8 mmol gcat−1 h−1). Photoelectrochemical analyses, including time‐resolved transient absorption spectroscopy (TAS) and in situ X‐ray photoelectron spectroscopy (XPS), reveal that monatomic Pt sites can effectively trap electrons, while Au nanoparticles act as hole sinks, thereby synergistically enhancing charge separation efficiency. Mechanistic investigations via in situ electron paramagnetic resonance (EPR) and Fourier transform infrared spectroscopy (FTIR) elucidate the reaction pathway: EG undergoes hole‐mediated oxidation to yield an aldehyde intermediate, which is subsequently attacked nucleophilically by hole‐derived •NH2, inducing sequential C─C bond cleavage and C─N bond formation. This work provides critical mechanistic insights for the sustainable synthesis of high‐value heteroatom‐containing chemicals from plastic waste.
Nonsymmorphic symmetry enforced Weyl nodal metal in chalcopyrite MnGeAs2
Organocatalytic Enantioselective [4 + 4] Cycloadditions of Furan <i>Ortho</i>‐Quinodimethanes
AbstractThe enantioselective [4 + 4] cycloaddition for the construction of cyclooctanoids is a challenging transformation in organic chemistry. Herein, we present the first organocatalytic enantioselective [4 + 4] cycloaddition of furan ortho‐quinodimethanes, activated by dearomatization of the heteroaromatic compound, which thereby allows for the cycloaddition with dienes. The [4 + 4] cycloaddition is catalyzed by a quinine‐derived primary amine in combination with a chiral phosphoric acid and a carboxylic acid affording cyclooctanoids isolated as a single diastereoisomer in good yields and with up to 94% ee. This reaction concept allows for the formation of cyclooctanoids without benzofusion, as demonstrated by oxidative opening of the furan ring. Computational studies of the reaction mechanism for the [4 + 4] cycloaddition point to a stepwise process. Surprisingly, the stereochemical outcome of the reaction is attributed to protonation of the two organocatalyst‐bound cyclooctanoid intermediates leading to a preferred set‐up for catalyst elimination to account for the absolute configuration of the cyclooctanoid.