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Molecular dynamics insights into non-covalent functionalization of boron nitride nanotubes for doxorubicin delivery
High‐Capacity and Long‐Life Cathode Constructed Solely by Carbon Dots for Aqueous Zinc‐Ion Batteries
Abstract Carbon dots (CDs) have been explored widely in the electrochemistry field, owing to their unique structures and rich properties. However, in the reported devices, such as batteries and supercapacitors, CDs are always used as additives to modify the electrodes or regulate the electrolytes because they have been regarded as inert and low‐capacity materials all along. Here, for the first time, o ‐phenylenediamine derived CDs are selected as the only protagonist to construct cathode materials for aqueous zinc‐ion batteries (ZIBs). Such CDs (p‐CDs) have a special π‐conjugated phenazine‐based structure, with carbon cores for electrical conductivity and active sites for embedding Zn 2+ and H + . The p‐CDs solely constructed cathode material delivers a superior capacity of 290 mAh g −1 at 0.1 A g −1 and a decent capacity of 103 mAh g −1 at an ultra‐high current density of 10 A g −1 , as well as an ultrahigh ion diffusion coefficient of 10 −8 ∼ 10 −7 cm 2 s −1 . The p‐CDs assembled ZIBs exhibit a stable long‐term cycling, retaining 87.4% of the original capacity after 10 000 cycles. Various characterizations and theoretical calculations prove that the electron‐deficient N as the active sites on p‐CDs can embed/release Zn 2+ and H + reversibly.
Spatiotemporal variation and driving forces of carbon storage in the Fuhe river basin, China
Digital biomarkers for interstitial glucose prediction in healthy individuals using wearables and machine learning
Abstract A personalized low-glycemic diet, maintaining stable blood glucose levels, aids in weight reduction and managing (pre-)diabetes and migraines in individuals. However, invasiveness, high cost, and limited lifecycle of continuous glucose monitoring (CGM) devices restrict their widespread use. To address these issues, we investigated machine learning (ML) approaches for glucose monitoring using data from non-invasive wearables. Our study comprised two phases involving healthy participants: The main study included two experimental sessions lasting 7–8 h with two standardized test meals, totaling over 1550 interstitial glucose (IG) measurements with CGM, and high-frequency multimodal data collected by two different non-invasive sensor devices. The follow-up study involved more than 14,400 IG measurements. Using ML approaches, correlations between glycemic measures and sensor data were assessed to estimate the feasibility of accurately predicting personalized IG alterations in real-time. An ensemble feature selection-based light gradient boosting machine (LightGBM) algorithm, omitting the need for food logs, was developed. This algorithm achieved a root mean squared error (RMSE) of 18.49 ± 0.1 mg/dL and a mean absolute percentage error (MAPE) of 15.58 ± 0.09%, demonstrating the feasibility of non-invasive glucose monitoring with high accuracy, which paves the way for novel approaches in the objective prevention of diet-related diseases.
Electrocatalytic C─S Cross‐Coupling via Engineered Frustrated Lewis Acid‐Base Pairs for High‐Efficiency Methanesulfonate Synthesis
Abstract The electrochemical synthesis of sulfonyl compounds under mild conditions remains a significant challenge due to the reliance on harsh reagents, high energy consumption, and low selectivity in conventional methods. Herein, we report a novel strategy for efficient C─S bond formation through in situ modulation of frustrated Lewis acid‐base pairs within a copper‐based metal‐organic framework (CuBDC‐XN). By precisely engineering electron‐deficient Cu Lewis acid sites and electron‐rich XN‐functionalized Lewis base sites, this bifunctional catalyst enables the synergistic co‐reduction of SO 3 2− and CO 2 into methanesulfonate (MS) at ambient conditions with a Faradaic efficiency of 13.77% (−0.78 V versus RHE). Mechanistic studies reveal that the frustrated Lewis pairs selectively stabilize key intermediates (*CHO and SO 3 2− ) via electrostatic interactions, facilitating nucleophilic attack and C─S coupling with a reduced energy barrier (0.48 eV). In situ spectroscopic analyses and DFT calculations further elucidate the dynamic adsorption‐configuration regulation and intermediate evolution pathway. This work not only establishes a molecular‐level understanding of cooperative Lewis acid‐base catalysis but also provides a universal design principle for the sustainable electrosynthesis of value‐added organosulfur compounds.
Correction: CLN3 disease disrupts very early postnatal hippocampal maturation
Highly Oxygen‐Tolerant and Self‐Adaptive Surface‐Initiated Bimetal‐Mediated Controlled Radical Polymerization
Abstract We report herein a self‐adaptive surface‐initiated bimetal‐mediated controlled radical polymerization (SI‐BMCRP) for fabricating various polymer brushes using microliter volumes under ambient conditions. The introduction of bimetal CuZn alloy can self‐adaptively control the dissociation of copper species while still realizing the controllability of polymer brush growth with high oxygen tolerance at a wide range of distances between the bimetal alloy and the initiator‐modified substrate. The successful fabrication of multiscale and multifunctional polymer brushes with high‐end group fidelity and patterned architectures further demonstrates the robust nature of SI‐BMCRP. The resultant polymer brushes show great potential for new applications in moisture‐enabled electricity generation, breath monitoring, and speech recognition.
Development and mathematical modelling of a dual-rotor machine for wind turbine power generation system
Lightweight multiscale information aggregation network for land cover land use semantic segmentation from remote sensing images
A photovoltaic power forecasting method based on the LSTM-XGBoost-EEDA-SO model
The effect of NF-kB and MAPK mediated Proinflammatory microenvironment on renal aging and amyloid deposition in elder rats
Abstract Low-grade inflammation associated with the aging process exerts functional and morphological effects on multiple organs. The kidney is an organ that is severely affected by the aging process. Our study aimed to determine the relationship between histopathological and immunohistochemical changes and age-related amyloid accumulation in rat kidney tissue. Wistar albino rats were divided into two groups: young adult and elder (n = 8, 24 and 104 weeks old, respectively). H&E, PAS, and Congo red staining and immunohistochemical staining for TNF-α, IL-6, occludin, GRP78, and mitogen-activated protein kinase (MAPK) were performed on the kidney tissues of the subjects. A significant difference was found between the groups in terms of glomerulus diameter/Bowman’s capsule diameter, percentage of sclerotic glomeruli, epithelial desquamation, loss of brush border, casts, tubular dilatation, cellular debris, and the presence of apoptotic cells. TNF-α, IL-6, GRP78, and MAPK protein levels were shown to increase significantly in aged rat kidneys, whereas occludin levels decreased significantly. No amyloid accumulation was found in the kidney, heart, skin, and small intestine tissues of either group. The results of our study suggest that the proinflammatory microenvironment required for AA amyloid deposition in systemic amyloidosis induced by low-grade inflammation in old age cannot be generated by the action of NF-κB, MAPK, and MAPK-activated JNK and AP-1 transcription factors alone.
Daily briefing: Fossil tracks might be earliest evidence of fish testing life on land
Effects of spinal versus general anesthesia on serum oxidative stress markers and cytokine release after abdominal hysterectomy: a non-randomized trial
Multiactivity of Nanozyme Liposome Regulates the Homeostasis of Biochemical Microenvironment
Abstract In living systems, cascade reactions involving multiple enzymes, critical for regulating the biochemical microenvironment's homeostasis, are essential to transplantation remodeling. However, for ready‐to‐use purposes, designing and constructing therapeutic liposomes that replicate natural cell functions during the initial transplantation phase remains a significant challenge in synthetic biology for tissue engineering. Herein, we developed a biomimetic liposome with multienzymatic nanozyme activity to regulate proinflammatory factors induced by exogenous implants. The liposomes were fabricated through the self‐assembly of artificial membranes on CeO 2 nanoparticles (NPs). These membranes, featuring a negatively charged surface analogous to endothelial cell (EC) membranes, effectively attenuate blood component adhesion and aggregation. The CeO 2 nanozyme not only hydrolyzes adenosine triphosphate/adenosine diphosphate (ATP/ADP) to adenosine monophosphate (AMP), reducing subsequent platelet aggregation, but also regulates biochemical microenvironment homeostasis, thereby promoting tissue regeneration. This work advances the development of cell‐like entities capable of modulating signaling communication between living and abiotic interfaces.
Risks of cataract surgery in solid and hematologic cancer survivors
‘Computing is a Black people’s thing’
Blood Retention and Kidney Clearance of Renal‐Clearable Gold Nanoparticles Strongly Correlate with Renal Injury Biomarkers
Abstract Renal‐clearable engineered nanoparticles are typically filtered through the glomeruli and transported along the renal tubules before entering the bladder. However, the effects of glomerular leakage and tubular injury, two common features of kidney diseases, on nanoparticle transport remain poorly understood. Herein, we investigated the blood retention, kidney accumulation, and renal clearance of Au₂₅(SG)₁₈ in a doxorubicin‐induced acute kidney injury (AKI) mouse model. By correlating its transport with proteinuria and urinary kidney injury molecule‐1 (KIM‐1), endogenous biomarkers of glomerular leakage and proximal tubular injury, respectively, we found that glomerular leakage, as indicated by a >50‐fold increase in proteinuria, did not enhance its blood clearance. Instead, tubular injury significantly reduced glomerular filtration, resulting in elevated blood retention, increased kidney accumulation, and reduced renal clearance of Au₂₅(SG)₁₈. Moreover, Au₂₅(SG)₁₈ blood retention exhibited a very strong positive correlation with urinary KIM‐1 (Pearson's coefficient r = 0.90), much stronger than KIM‐1 correlations with conventional glomerular filtration blood markers such as serum creatinine. This suggests that Au₂₅(SG)₁₈ could serve as a sensitive exogenous blood marker of tubular injury, expanding the diagnostic potential of renal‐clearable nanoparticles in kidney diseases.