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Research on quantitative prediction method of structural fractures in metamorphic rock reservoirs
Evidence based consensus statements for digital tools to address youth mental health literacy
Abstract Mental health disorders typically emerge in early life and can be modified through prompt intervention. Mental health literacy is the multi-dimensional knowledge of mental health disorders to recognize, manage, or prevent mental health disorders. Enhancing youth mental health literacy through information communication technologies already adopted by youth may be an accessible and effective approach to address the ongoing mental health crisis. We used an interconnected, three phase process following co-design methods to determine evidence-based consensus statements to conceptualize and develop the Youth MindTrack and to inform future digital tools to support youth mental health literacy. In Phase I, a scientific team (N = 21; 24% youth) adhered to deliberative dialogue and priority setting methods to develop strategic priorities. Phase II consisted of a modified Delphi consensus process to determine evidence-based consensus statements (N = 352 (13% youth) Round 1; N = 87 (33% youth) Round 2). Semi-structured focus groups in Phase III were conducted to refine the consensus statements (N = 16, 25% youth) and design the digital mental health literacy tool (N = 24, 33% youth). Twenty-one consensus statements encompassing four domains were produced: (1) Understanding mental health (N = 4); (2) Exercising mental health (N = 6); (3) Engaging with digital support (N = 8); and (4) Evaluating digital support (N = 3). Content analysis of discussions identified 16 themes mapped to the domains of mental health literacy and user-interface, design considerations for digital tools on mental health literacy more broadly. The resulting design of the Youth MindTrack tool to support mental health literacy included four main interactive sections designed to be downloaded and completed by youth on a digital device. We determined 21 evidence-based consensus statements that underpinned the conceptualization and development of the Youth MindTrack: a downloadable digital tool to support youth mental health literacy. The data supports proceeding to pilot testing to assess the tool’s usability, acceptability, and perceived effectiveness prior to implementation, and provides evidence that an iterative and participatory research-based process with youth can help adapt health technology to their needs.
Association between cholecystectomy and the risk of new-onset metabolic dysfunction-associated steatotic liver disease: a risk-stratified cohort study
Study on the mechanism of anchoring parameters of anchor rods in cemented broken surrounding rock
EDM-based analysis of Fe-based shape memory alloys using Cu-W electrodes with multiple output optimization and microstructural validation
Abstract Shape Memory Alloys (SMAs) are pivotal in diverse industrial applications due to their exceptional properties, including actuation, biocompatibility, and adaptability in aerospace, biomedical, and military domains. However, their complex machinability often leads to high costs and suboptimal surface quality when processed using traditional methods. Using Response Surface Methodology (RSM) with a Central Composite Design (CCD), this study evaluated the effects of input parameters, including pulse on time (Ton), pulse off time (Toff), peak current (Ip), and gap voltage (GV), on material wear responses during Electrical Discharge Machining (EDM). Fe-based Shape Memory Alloys (SMAs) were machined using a Cu-tungsten electrode to investigate the wear characteristics of both workpieces and tool electrodes. Results revealed that Workpiece Material Removal Rate (WOW) ranged from 11.30 to 65.17 mm³/min, and Tool Wear Rate (WOTE) varied from 0.0062 to 0.01127 g/min. Scanning Electron Microscopy (SEM) of machined surfaces showcased craters, micro-cracks, and recast layers, elucidating the correlation between process parameters and surface integrity. Multi-objective optimization using the desirability approach identified optimal conditions for balancing machining efficiency and surface quality. This research provides a comprehensive understanding of the EDM process for Fe-based SMAs, paving the way for improved machinability and expanded industrial applications.
Chitosan pre- and post-treatment modulates molecular and physiological responses to salinity in Brassica Napus L
Echocardiographic assessment of left atrial structural and functional changes after catheter ablation in paroxysmal atrial fibrillation with preserved ejection fraction
Temporal and spatial response of agricultural drought to meteorological drought in inner Mongolia plateau inland river basin
Seasonal and interannual variations in material transport in the Korea Strait originating from the Taiwan Strait
Working-age patients with medically unexplained oral symptoms who receive public assistance in Japan
Open pit design for improved gold recovery at Ula-Ulo placer deposit in Guji, southern Ethiopia
Study on the influence of peripheral eye on over-excavation during mountain tunnel blasting construction
Integrated electrodes for the nutrient removal from municipal wastewater using electrocoagulation technology
Electrochemical performance of a novel 1-(benzo[d]thiazol-2-yl)-3-methylguanidine as effective corrosion inhibitor for carbon steel in 1 M hydrochloric acid
Abstract Guanidine benzothiazole (G) and 1-(benzo[d]thiazol-2-yl)-3-methylguanidine (AG) were successfully synthesized and characterized by infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopy. Both compounds act as novel corrosion inhibitors for carbon steel in 1.0 M hydrochloric acid solution. Their inhibition efficiency was evaluated using potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS). Surface analysis via scanning electron microscope (SEM) and energy dispersive X-ray (EDX) confirmed the formation of a protective film on the steel surface. PDP results indicate that G and AG function as mixed-type inhibitors, with inhibition efficiency increasing with concentrations, reaching a maximum of 80% for G and 91.4% AG. The AG compound was seen to retard the rate of corrosion of carbon steel more effective than PP compound. Adsorption followed the Langmuir isotherm, suggesting monolayer adsorption on the metal surface. The high inhibition efficiencies were attributed to strong adsorption and the formation of a dense, protective barrier film. The corrosion inhibition performance of the synthesized molecule was evaluated using density functional theory (DFT). Quantum chemical parameters, including highest occupied molecular orbital (HOMO) and lowest occupied molecular orbital (LUMO), energy gap, hardness, and dipole moment, and other quantum descriptors were analyzed. Density functional theory (DTF) calculation supported the experimental finding, showing that the high efficiency correlates with a low energy gap and high dipole moment, which promote electron transfer and adsorption strength. Theoretical and experimental results showed strong agreement, confirming the potential of G and AG as effective inhibitors for carbon steel.
Ameliorative effects of Berberine chloride against 5-fluorouracil-induced cardiotoxicity in Sprague Dawley rats
Abstract 5-Fluorouracil (5-FU) is the most commonly used chemotherapeutic agent for solid malignancies. Although it has crucial therapeutic effects, it ranks as the second most cardiotoxic antineoplastic agent. Berberine (BBR) is a quaternary benzylisoquinoline alkaloid with promising antioxidant properties. The current study aimed to assess the palliative effect of BBR on 5-FU-induced cardiotoxicity in rats. Fifty male Sprague Dawley rats were randomly divided into five groups: negative control, which received 2% DMSO orally (PO) for 2 weeks; cardiotoxic, which received a single intraperitoneal (IP) injection of 5-FU (150 mg/kg); groups 3 and 4, which received a single IP injection of 5-FU (150 mg/kg) followed by BBR (50 mg/kg and 100 mg/kg, respectively) PO for 2 weeks; and a BBR-only group, which received BBR (100 mg/kg) PO for 2 weeks. On the 14th day, all groups underwent ECG evaluation. Blood and heart samples were collected 24 h after the last dose for further investigations. 5-FU induced significant alterations in the ECG pattern and caused a significant increase in cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and malondialdehyde (MDA). Moreover, it led to decreased levels of superoxide dismutase (SOD), reduced glutathione (GSH), and total antioxidant capacity (TAC). Our data suggest that BBR could mitigate 5-FU-induced cardiotoxicity by modulating cardiac injury markers, normalizing cTnI, CK-MB, and LDH levels, reducing oxidative stress by lowering MDA levels, and increasing SOD, GSH, and TAC levels. Additionally, BBR inhibited apoptotic events by suppressing caspase-3 activation and upregulating Bcl-2 expression, reduced the inflammatory response by downregulating cyclooxygenase-2 (COX-2) and tumor necrosis factor-alpha (TNF-α) expression levels, and decreased the risk of thrombosis by increasing endothelial nitric oxide synthase (eNOS) expression levels. In conclusion, BBR exerts ameliorative effects against 5-FU-induced cardiotoxicity in rats.
Nanoengineered cotton wipes for antiviral protection and environmental compatibility
Abstract Nanotechnology-based modifications enable the development of high-performance materials, expanding their applications beyond conventional uses. This study presents the production of sustainable antiviral cotton wipes through the nanoengineering of cotton fibers and investigates their mineralization behavior in compost and marine environments. Silver (Ag) nanoparticles, averaging 22 nm in diameter, were synthesized in situ using the inherent reducing agents present in raw cotton fiber and embedded within the fiber matrix. The modified cotton fibers were incorporated into nonwoven wipes using a hydroentanglement process at 20 wt%, yielding cotton wipes containing 225 mg/kg of Ag nanoparticles. The Ag-nanoengineered cotton wipes demonstrated a 99.68% reduction in virus titer against Feline calicivirus in a surface time-kill test using ready-to-use, pre-saturated wipes. Mineralization analyses indicated that both control and Ag-engineered cotton wipes followed first-order decay kinetics in compost and marine environments, with no significant difference in overall mineralization behavior. Ag-nanoengineered cotton wipes exhibited slightly lower mineralization rates, extended induction periods, and delayed maximum mineralization rates compared to control cotton wipes. Nanoengineering increased the half-life of cotton wipes by 19% in compost and 8% in marine conditions, suggesting complete mineralization within one month in compost and two months in marine environments.