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Comparative study of early onset cancer burden between China and the United States from 1990 to 2021
The inhibitory effect of M2 macrophage-derived exosomes on gefitinib resistant lung adenocarcinoma cells through the MIF/TIMP1/CD74 axis
Phytochemical profiling and network pharmacology-based prediction of Pelargonium graveolens essential oil in the context of Guillain-Barré syndrome
Abstract Guillain-Barré syndrome (GBS) is a rare autoimmune disorder with limited treatment options. This study investigates the chemical composition of Pelargonium graveolens essential oil and explores its potential interaction with GBS-related molecular targets using in-silico tools. Essential oil was analyzed using GC–MS. Identified components were subjected to network pharmacology analysis and molecular docking to assess binding affinities with GBS-relevant proteins, particularly TNF-α. Thirty compounds were identified, with citronellol (26.74%) and geraniol (20.28%) as major components. Comparative phytochemical analysis showed consistency with global P. graveolens chemotypes. Docking results suggest high binding affinity of citronellyl and geranyl derivatives toward TNF-α. These findings support further investigation of P. graveolens oil as a potential modulator of inflammatory pathways in GBS.
Transfer learning driven fake news detection and classification using large language models
Publisher Correction: Graphical model analysis of subjective well-being and various factors in Japanese adults from the Iwaki cross-sectional study
Author Correction: Bmi-1 promotes the proliferation, migration and invasion, and inhibits cell apoptosis of human retinoblastoma cells via RKIP
Reduced risk of lymphedema after immediate breast reconstruction in breast cancer: a retrospective nationwide study
Machine learning enables legal risk assessment in internet healthcare using HIPAA data
Integrin β5 interacts with G3BP1 through activating FAK/Src signaling pathway to promote gastric carcinogenesis
A novel cuproptosis-related genes nomogram on the prognosis and immune microenvironment of breast invasive carcinoma
Author Correction: Clinical significance and effect of lncRNA HOXA11-AS in NSCLC: a study based on bioinformatics, in vitro and in vivo verification
Exploring the nucleus accumbens circuit and oxytocin therapy in a Sapap3 knockout mouse model of trichotillomania
Innovative approach to IOL-bag complex fixation with Siepser’s scleral sliding knots in pseudoexfoliation syndrome
Federated learning with enhanced cryptographic security for vehicular cyber-physical systems
A novel blockchain technology-based supply chain coordination considering classified after-sales services of electronic products
Correction: Predictors of fatigue improvement in multimodal, multimodal-aerobic and aerobic exercise intervention studies in breast cancer survivors with cancer-related fatigue
Room-temperature ethylene glycol sensor based on cuprous oxide/MXene films
Abstract This study demonstrates a high-performance room-temperature ethylene glycol (EG) gas sensor using Cu2O/MXene bilayer films on quartz crystal microbalance (QCM) substrates, addressing critical needs for industrial safety and environmental monitoring. The fabricated sensors were systematically characterized by XRD, FTIR, and FESEM, revealing that the Cu2O/MXene bilayer configuration achieved exceptional performance with an ultra-low detection limit of 381 ppb, high sensitivity of 22.8 Hz/ppm, and excellent selectivity compared to individual Cu2O, MXene, or their mixture films. The enhanced sensing capability originates from synergistic effects between p-type Cu2O and conductive MXene, forming a Schottky junction that facilitates charge transfer and promotes EG adsorption through combined physisorption mechanisms involving hydrogen bonding with MXene’s functional groups (OH, O, F) and interactions with oxygen species on Cu2O nanoparticles. At 72 ppm EG concentration, the bilayer sensor exhibited 12.6-fold, 3.6-fold, and 2.34-fold higher response than pure Cu2O, MXene alone, and their mixture film, respectively. While humidity tests showed a moderate ~ 15% response reduction at 60% RH, the Cu2O/MXene bilayer maintained robust performance, establishing it as a cost-effective and reliable room-temperature sensing platform suitable for next-generation gas detection applications in challenging environments.
Rapid and reliable species-level identification from clinical samples using 16S rRNA gene nanopore sequencing analysis
L-shaped association of the non-high-density lipoprotein to high-density lipoprotein ratio with low bone mass disorders
The impact of the war in Ukraine on the well-being of German medical students: a mixed-methods study
Abstract The ongoing aggression war by Russia in Ukraine underscores the need to explore the impact of geopolitical crises on students’ well-being within the system university. Previous studies have raised concern regarding rising mental health issues among students, exacerbated by war-related stressors. The effects extend to non-war-involved countries on several levels, with heightened anxiety and fear reported for students. In this study, the affectedness of well-being, perceived stress and work engagement among German medicine students is surveyed in a cross-sectional multi-methods study before and after the initial war occurrences in Ukraine were reported. Results show lessened well-being and increase perceived stress, but non significantly affected work engagement. The students report several demands and resources to cope with stressors and maintain ongoing study motivation and capability. By understanding the personal repercussions of systemic crises, this study seeks to identify longitudinal support needs for medical students navigating uncertain times.