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Parathyroid glands viability assessment and identification during surgery with multimodal diffuse reflectance spectroscopy and NIR autofluorescence probe
New improved hybrid genetic algorithm for optimizing facility layout design of reconfigurable manufacturing system
Fabrication of ZnFe2O4@g-C3N4 for enhanced photo-fenton effect and visible light-driven organic dye degradation
Loneliness and depressive symptoms in institutionally isolated Polish adolescents explored through network psychometrics
Abstract This research investigates the link between depression and loneliness in 311 adolescents (87.8% boys; M age=15.8) in Polish Youth Correctional Centres. It focuses on identifying depression symptoms associated with loneliness, understand the centrality of loneliness in the depression symptoms network and examine the effect of various loneliness measurement methods on this relationship. The study reveals that loneliness is directly related to four affective depression symptoms: sadness, worthlessness, anhedonia and restlessness, which subsequently influence somatic symptoms. Unlike in prior research, loneliness has the least central role in the depression symptom network. The loneliness measurement method (direct/indirect) does not significantly impact its relationship with depressive symptoms. The study suggests using a simple loneliness question in network research, which is less burdensome for respondents, and discusses the reasons for the low centrality of loneliness in the network. The results underscore the significance of emotion regulation interventions for isolated adolescents’ well-being.
Caffeine intake is inversely associated with osteoporosis risk based on cross-sectional and genetic evidence
Abundance and transmission of antibiotic resistance and virulence genes through mobile genetic elements in integrated chicken and fish farming system
Compound 48/80 increases bladder compliance by activating MMP-2 and inhibiting TIMP-2
Decoding public sentiment topics in google map reviews on urban infrastructure development of belt and road initiative
Linker-GPT: design of Antibody-drug conjugates linkers with molecular generators and reinforcement learning
An in vitro study on the efficacy of nanoparticles and nanocomposites as coating materials on surgical sutures
Abstract Upgrading the surgical sutures, as the main wound closure device, is essential. The evolution of bacterial resistance and the plummeting of antibiotics have directed research toward augmented sutures. Nanotechnology has provided answers to these concerns. The use of bacterial isolates as bio-factory for synthesized silver nanoparticles (AgNPs) and silver nanocomposites via a one pot ex situ method provides environmentally friendly silver nanocomposites in addition to the use of chitosan and polyvinyl alcohol polymers as carriers. Transmission electron microscopy (TEM) and zeta potential analysis revealed spherical negatively charged AgNPs. These nanoparticles and nanocomposites were used as coatings for absorbable vicryl and nonabsorbable silk surgical sutures. Atomic force microscopy (AFM) 3D images of these coated sutures showed a significant decrease in surface roughness with improved surface topography, specifically with chitosan-silver (CS-Ag) vicryl coated sutures with effective attachment of the nanocomposite and nanoparticles thin film on the suture surface. Field emission scanning electron microscopy with energy dispersive x-ray spectroscopy (FE-SEM/EDX) analysis showed the significant presence of the thin film of coating materials on the surface of the sutures and the significant elemental presentation of Ag. Vicryl and silk coated CS-Ag sutures showed significant antibacterial and antibiofilm activities against both gram positive and gram-negative bacterial isolates. AgNPs coated silk and vicryl sutures recorded the lowest amounts of Ag ions at 0.03–0.45 ppm released after 14 days, while polyvinyl alcohol-silver (PVA-Ag) coated ones showed the highest rates at 0.75–0.93 ppm.
Analysis of spatiotemporal evolution and driving factors of ecological environment quality in the Ili-Balkhash Lake Basin in Central Asia
Integrative network pharmacology and experimental validation of anti-inflammatory triterpenoids from hawthorn leaves
Agricultural production and international trade analysis of competitiveness between natural and conventional dyes in the textile industry
Optimal scheduling of integrated energy system with gas–liquid phase change carbon dioxide energy storage considering multi-layer low-carbon benefits
Stock composition of cryptic Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus) in the Restigouche River and estuary, Canada
A multi layered encryption framework using intuitionistic fuzzy graphs and graph theoretic domination for secure communication networks
Antibacterial activity of a conventional hydrogel and a nanoparticle based hydrogel containing Satureja khuzestanica essential oil
PGC-1 alpha overexpression in the skeletal muscle results in a metabolically active microbiome which is independent of redox signaling
Abstract In this study, we investigated the potential relationship between the mitochondrial network and the microbiome using wild-type and skeletal muscle-specific PGC-1α (Pparg coactivator 1 alpha) overexpressing mice, both with and without exercise training. Basal PGC-1α levels were significantly higher in the skeletal muscle (J Physiol Biochem 80:329–335, 2024. https://doi.org/10.1007/s13105-024-01006-1 ) and, notably, in the colon, which is anatomically proximal to the microbiome. However, no significant changes were observed in cell signaling or mitochondria-related proteins within the colon. On the other hand, mitochondrial H₂O₂ production in the colon decreased in the PGC-1α overexpressing group. The relative abundance of several bacterial taxa differed between wild-type and PGC-1α overexpressing groups at baseline condition, indicating a shift in the microbiome milieu probably to cope with the increased metabolism, enhanced short-chain fatty acid utilization, and improved endurance capacity. Ten weeks of exercise training differentially modulated the host microbiome in PGC-1α overexpressing and wild-type mice, facilitating adaptations to a broad range of exercise-induced challenges. The results of this study provide new insights into the possible cross-talk between mitochondria and the microbiome.