Browse Articles

Trends in the development of cellular and gene therapy in China

Synthesis, characterization, antioxidant and antimicrobial activities, and computational studies of chitosan nanoparticles loaded with vitamin E and clove essential oil

Oncolytic virus drought continues, as Replimune fails to secure FDA cancer approval

Sustainable biodiesel production from cottonseed oil using a nickel-doped eggshell heterogeneous catalyst optimized via response surface methodology

In vivo CAR T cells gain traction, with AbbVie’s US$2.1 billion acquisition of Capstan Therapeutics

Biochemical responses in Salvia limbata CA Mey. towards mercury and lead induced in vitro oxidative stress

Mimicking the health benefits of exercise

3D printed antibacterial and anti-inflammatory scaffold containing vanillin-loaded Soluplus nanomicelles for healing of infected wounds

De novo design of macrocycles

Predicting factors associated with anxiety by patients undergoing treatment for infectious diseases using a random-forest machine learning approach

Neoantigen-targeting vaccine treats melanoma

A de novo variant of RERE was identified in a patient with neurodevelopmental disorder, enuresis and scoliosis

PDE5 inhibitor restores dendritic cell migration

Deep learning model using squeezenet and promoted ideal gas molecular motion for music genre classification from audio spectrograms

Event-triggered smart dual hormone artificial pancreas for patient-specific drug delivery

Research on train wheel point cloud registration algorithm based on key points by fusing Super-4PCS and ICP

Comparative study of advanced hydrogen liquefaction using triple cascade mixed refrigerant cycles with integrated energy exergy economic and environmental analysis

Abstract Hydrogen, as a clean energy source, is recognized as a pivotal energy carrier in the global transition to sustainable energy systems and serves as a crucial pathway for energy storage and efficient utilization within cryogenic systems. Hydrogen liquefaction is one of the most promising methods for increasing its energy density, enabling more efficient storage, transportation, and utilization in large-scale energy systems. However, substantial challenges persist, particularly regarding the high energy consumption associated with the liquefaction process. This study addresses these challenges by proposing two designs for a triple-cascade mixed refrigerant cycle aimed explicitly at reducing energy consumption for high-density hydrogen storage: 66.7 kg/m 3 at − 245 °C (Case 1) and 76 kg/m 3 at − 249 °C (Case 2). The proposed systems utilize two mixed refrigerant cycles for the precooling and cryogenic stages. In Case 1, pure nitrogen is employed as the third refrigerant in the precooling stage, whereas Case 2 incorporates a regenerative cryogenic hydrogen cycle as the third refrigerant throughout the entire system, coupled with a carbon dioxide cycle for compressor cooling. Simulations were conducted using Aspen HYSYS, with optimization through the Aspen Optimizer algorithm. The results indicate that Case 1 achieves a specific energy consumption (SEC) of 6.98 kWh/kgH₂, representing a 17.4% reduction from the baseline, while Case 2 reduces SEC to 6.19 kWh/kgH₂, a 14.5% decrease. The exergy analysis of the heat exchangers shows a 37% reduction in exergy destruction in Case 2 compared to Case 1. Additionally, Case 2 demonstrates a 5.8% reduction in capital expenditure and a 22% reduction in carbon footprint (CFP). These findings highlight the potential of the proposed triple-cascade process to enhance energy efficiency, improve both thermodynamic and economic performance, and reduce environmental impact.

Biased adrenergic receptor agonist tackles metabolic disease

Computer vision based efficient segmentation and classification of multi brain tumor using computed tomography images

Kueselia aquadivae gen. nov., sp. nov., the first member of the family Isosphaeraceae isolated from subsurface percolates

Abstract Subsurface habitats, found under various geological conditions, exhibit diverse microbial communities. The vadose zone, a previously unexplored subsurface compartment, connects the surface to phreatic groundwater. Drilling into the subsurface allows access to these habitats for microbial diversity study. Due to nutrient limitation, subsurface microbiomes adapt, potentially producing biotechnologically important biomolecules. Planctomycetota, known for possessing about 20 to 45% of protein-coding genes of unknown function, may be relevant in this context. A percolate water sample from the weathered bedrock of the Hainich Critical Zone Exploratory (CZE; Thuringia, Germany) was processed to enrich planctomycetes, leading to the isolation of an uncharacterized Isosphaeraceae member, strain EP7T. Strain EP7T forms round, pink colonies, and spherical, non-motile cells that divide asymmetrically by budding. It grows between 10 and 24 °C and over a range of pH 5 to pH 10. Its genome size is 7.2 Mbp, and its DNA G + C content is 66.7%. Polyphasic characterization justifies the assignment of strain EP7T to a novel species within a novel genus. We introduce the name Kueselia aquadivae for the novel taxon with strain EP7T as the type strain of the novel species. Strain EP7T represents the first Isosphaeraceae member isolated from vadose zone percolate water.