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A prudent planetary limit for geologic carbon storage

Nature Matthew J. Gidden, Siddharth Joshi, John J. Armitage et al. Sep 04, 2025 DOI: 10.1038/s41586-025-09423-y

Abstract Geologically storing carbon is a key strategy for abating emissions from fossil fuels and durably removing carbon dioxide (CO 2 ) from the atmosphere 1,2 . However, the storage potential is not unlimited 3,4 . Here we establish a prudent planetary limit of around 1,460 (1,290–2,710) Gt of CO 2 storage through a risk-based, spatially explicit analysis of carbon storage in sedimentary basins. We show that only stringent near-term gross emissions reductions can lower the risk of breaching this limit before the year 2200. Fully using geologic storage for carbon removal caps the possible global temperature reduction to 0.7 °C (0.35–1.2 °C, including storage estimate and climate response uncertainty). The countries most robust to our risk assessment are current large-scale extractors of fossil resources. Treating carbon storage as a limited intergenerational resource has deep implications for national mitigation strategies and policy and requires making explicit decisions on priorities for storage use.

Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial

New England Journal of Medicine Ania M. Jastreboff, Donna H. Ryan, Harold E. Bays et al. Sep 04, 2025 DOI: 10.1056/nejmoa2504214

The Corporatization Deal — Health Care, Investors, and the Profit Priority

New England Journal of Medicine Amitabh Chandra, Mark Shepard Sep 04, 2025 DOI: 10.1056/nejmp2505258

Porcine Xenotransplantation in End-Stage Kidney Disease

New England Journal of Medicine Sep 04, 2025 DOI: 10.1056/nejmc2508235

One Dose versus Three Doses of Benzathine Penicillin G in Early Syphilis

New England Journal of Medicine Edward W. Hook, Jodie A. Dionne, Kimberly Workowski et al. Sep 04, 2025 DOI: 10.1056/nejmoa2401802

Generative AI in Medicine

New England Journal of Medicine Sep 04, 2025 DOI: 10.1056/nejmc2510443

Experiment puts ‘spoon bending’ to the test

Nature Sep 04, 2025 DOI: 10.1038/d41586-025-02535-5

Antiquated Tools to Fight an Ancient Foe

New England Journal of Medicine Lindley A. Barbee, Laura H. Bachmann Sep 04, 2025 DOI: 10.1056/nejme2508410

AI-agent ethics should consider sentient non-human animals

Nature Borbala Foris, Jean-Loup Rault Sep 04, 2025 DOI: 10.1038/d41586-025-02796-0

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes

New England Journal of Medicine Trevor W. Reichman, James F. Markmann, Jon Odorico et al. Sep 04, 2025 DOI: 10.1056/nejmoa2506549

Include climate impacts when protecting infrastructure

Nature Hongfang Lu, Y. Frank Cheng Sep 04, 2025 DOI: 10.1038/d41586-025-02797-z

Malnutrition in Older Adults

New England Journal of Medicine Sep 04, 2025 DOI: 10.1056/nejmc2509709

Unifying gravity and quantum theory requires better understanding of time

Nature Fay Dowker Sep 04, 2025 DOI: 10.1038/d41586-025-02756-8

The Rise of Drug Innovation in China — Implications for Patient Access in the United States and Globally

New England Journal of Medicine Kerstin N. Vokinger, Guanqiao Li, Olivier J. Wouters Sep 04, 2025 DOI: 10.1056/nejmp2505821

Radiation Pneumonitis

New England Journal of Medicine Max Peters, Paul Jeene Sep 04, 2025 DOI: 10.1056/nejmicm2503312

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression

New England Journal of Medicine Per-Ola Carlsson, Xiaomeng Hu, Hanne Scholz et al. Sep 04, 2025 DOI: 10.1056/nejmoa2503822

Air taxis will soon be in our skies — if batteries can be made safer

Nature Liqiang Mai, Xiaocong Tian, Yunlong Zhao Sep 04, 2025 DOI: 10.1038/d41586-025-02758-6

Author Correction: RNA codon expansion via programmable pseudouridine editing and decoding

Nature Jiangle Liu, Xueqing Yan, Hao Wu et al. Sep 04, 2025 DOI: 10.1038/s41586-025-09464-3

Management of Acute Type B Aortic Dissection

New England Journal of Medicine Firas F. Mussa, Panos Kougias Sep 04, 2025 DOI: 10.1056/nejmra2405257

Veterinarians need to be part of West Nile disease storytelling

Nature Giovanni Di Guardo Sep 04, 2025 DOI: 10.1038/d41586-025-02795-1