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Immediate effects of neuromuscular electrical stimulation on drop jump performance measured through kinematic analysis
Revolutionary hybrid ensembled deep learning model for accurate and robust side-channel attack detection in cloud computing
Prediction method of vertical sealing evolution form and distribution position of oil source faults
Medium plant cover maximizes fine-scale spatial heterogeneity in humid grasslands of Southwest China
An approach to flow field prediction over the horizontal axis wind turbine by passive flow control device using CNN-Autoencoder model
Acute effects of rapid versus sustained isometric contraction durations on countermovement jump performance in national level young male soccer players
Relational embeddedness, organizational learning ambidexterity, and competitive advantage in digital healthcare
Associations between patient-reported vision impairment in low luminance and vision-related quality of life in intermediate age-related macular degeneration
Abstract Intermediate age-related macular degeneration (iAMD) reduces vision under low-luminance conditions, affecting quality of life (QoL). The Vision Impairment in Low Luminance (VILL) questionnaire captures QoL domains relevant in iAMD but most AMD studies use the generic vision-related QoL measure Visual Function Questionnaire (NEI VFQ). To investigate associations between these generic and specific vision-related QoL instruments, and explore the added value of including the VILL over the NEI VFQ in future iAMD studies, we analysed cross-sectional study data from individuals with iAMD. Associations were investigated using age-adjusted regression models. We included 150 participants (73% women, 74.6 ± 7.8 years). VILL subscale scores were associated with NEI VFQ scores (p ≤ 0.014) and explained 62.0% to 67.9% in the variance of the NEI VFQ scores. Ceiling effects were more common in the visual functioning NEI VFQ subscale than in the VILL-Reading subscale (p = 0.039), while the emotional well-being scores did not differ signficiantly between the instruments. NEI VFQ scores, VILL-Reading and VILL-Mobility subscale scores were associated with best-corrected visual acuity in either eye. Thus, assessments of vision-related QoL in iAMD using a generic instrument and a low luminance vision-specific instrument yield comparable but not identical results. The VILL has less ceiling effects than the NEI VFQ, suggesting its suitability for iAMD intervention trials and added value over the NEI VFQ in populations with few functional deficits.
Telomerase inhibitors TMPyP4 and BIBR 1532 show synergistic antitumor activity in combination with chemotherapeutic drugs
Liver CT image segmentation network based on multi-scale feature fusion
An evaluation of maximizing production and usage of biofuel by machine learning and experimental approach
Enhancing social science research on cyberbullying through human machine collaboration
Electro-thermal evaluation of electrically conductive asphalt pavement containing recycled metal fiber
Construction of an infectious clone of novel duck picornavirus using the infectious subgenomic amplicon method
Physiological and growth responses of Chinese chives (Allium tuberosum) to elevated CO2 concentrations and infestation by fungus gnat (Bradysia impatiens)
Reliability assessment of friction stir welds in AA100 aluminium alloy using ANN and ANFIS predictive models
Discovery of novel disulfide-containing PD-1/PD-L1 inhibitor with in vivo influenza therapeutic efficacy
In vitro analysis of seven syphilis-causing Treponema pallidum strains revealed inherent growth rate differences
Abstract Previous in vitro long-term cultivation studies of Treponema pallidum subsp. pallidum (T. pallidum) strains have indicated potential differences in the length of generation times among individual strains. In the present study, we have determined in vitro growth rates of seven T. pallidum strains including three from the Nichols-like cluster (DAL-1, Madras, and Haiti B) and four from the SS14-like cluster (Mexico A, SS14, Grady, and Philadelphia 1). Despite the observed considerable variability, the results of standard subcultures identified growth differences between the two clusters during the long-term cultivation. Furthermore, in vitro monocultures with defined inoculum revealed differences among individual strains. During three week-long binary co-cultivations of seven strains (n = 21), different growth rates were confirmed for individual strains (p < 0.001) using PCR amplicon sequencing of genomic regions differentiating treponemal-pairs. The order of strains by decreasing growth rate in vitro was DAL-1, Madras, Mexico A, Haiti B, SS14, Grady, and Philadelphia 1. While the generation time of strain DAL-1 was 32.97 h, the slowest strain, Philadelphia 1, had generation time 43.5 h. These experiments revealed significant physiological differences between the T. pallidum strains, which may also be involved in the variable presentation of syphilis symptoms observed in previous decades.