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A graph attention network-based multi-agent reinforcement learning framework for robust detection of smart contract vulnerabilities
A novel neutrophil extracellular trap-related gene signature for predicting glioblastoma prognosis
Hydrostable hard tissue adhesives based on organophosphates and magnesium phosphates with strong bonding and cellular compatibility
Abstract Bone adhesives have significant potential for improving surgical procedures and can enhance and simplify them. Recently, phosphoserine-modified mineral-organic resorbable bone adhesives have shown particular promise. Among them, MgO/MgP-based cement exhibit high adhesive strength but suffer from water instability. This study introduces mineral-organic hard tissue adhesives based on organophosphates and magnesium phosphate with hydrolytic stability to enable cell testing. Amorphised magnesium phosphates enhanced reactivity, eliminating MgO additives. Alongside the established organophosphate phosphoserine (OPLS), sodium phytate was investigated as an alternative. We performed comprehensive mechanical and material characterizations, complemented by in vitro cytocompatibility assessments using osteoblastic MG-63 cells and osteoclastic RAW 264.7 cells differentiated with RANKL. Sodium phytate demonstrated strong adhesive properties, with an initial shear strength of 4.35 ± 0.86 MPa, retaining 1.3 ± 0.27 MPa after 7 days. However, it showed lower cytocompatibility with MG-63 cells than with OPLS. The OPLS/MgP combination exhibited both favorable cytocompatibility and strong adhesive performance, achieving an initial shear strength of 3.87 ± 0.53 MPa and maintaining 2.19 ± 0.69 MPa after 7 days. These findings underscore the potential of organophosphate-magnesium compound cement as viable candidates for mineral-organic hard tissue adhesives in surgical applications, combining excellent adhesive properties with favorable cytocompatibility.
Analysis of spatial and temporal distribution of grassland yield under grassland ecological subsidy policy
Entanglement witnesses and separability criteria based on generalized equiangular tight frames
Abstract In quantum information theory, measurements are represented by positive, operator-valued measures. In this paper, we use the operators corresponding to generalized equiangular measurements to construct positive maps. Their positivity follows from the properties of index of coincidence for few equiangular tight frames. These maps give rise to entanglement witnesses, which include as special cases many important classes considered in the literature. Additionally, we introduce separability criteria based on the correlation matrix and analyze them for various types of measurements.
Correction: Anatomic and operative predictors of aortic expansion following aortic dissection repair
UK Royal Society adopts ‘subscribe to open’ publishing model
A qualitative study to identify the determinants and strategies for the prevention of dengue fever in Iran
Abstract In June 2024, Iran reported a dengue fever outbreak beginning in Hormozgan province and spreading to several other provinces, raising significant public health concerns. To mitigate the disease’s impact, multiple meetings were held to explore control strategies, emphasizing community participation through focus groups. This study aimed to identify the determinants, priorities, and control strategies for combating dengue fever and breeding sites of Aedes mosquitoes in Hormozgan province, Iran. This qualitative study employed purposive sampling with maximum variation to conduct 13 focus group discussions (FGDs) with 163 participants (8–13 per group) in Hormozgan Province during June-July 2024. Participants included health department officials, municipal managers, port authorities, and community leaders. Data were analyzed using thematic analysis following Braun and Clarke’s six-phase approach, with trustworthiness ensured through member checking and peer debriefing. These FGDs included health department officials, governors, municipal managers, medical university representatives, Shipping offices, and influential community leaders involved in dengue prevention education. Through these discussions, seven key determinants for dengue fever control in Iran were identified. The primary factors were: (a) Environmental (b) Therapeutic and health care (c) interdisciplinary cooperation (d) Administrative, legal, and regulatory determinants (e) Financial and budgetary (f) Educational determinants and (g) Social determinants. Effective community empowerment and health program decision-making require cooperation across various organizations, enhancement of high-risk environments, and fostering a sense of responsibility and participation among community members. Given the rise of re-emerging diseases globally, identifying their determinants is crucial for quick disease control in the region and for preventing global pandemics.
Mitochondrial-dependent apoptosis and STAT3 activation induced by oxidative stress in pemphigus vulgaris
Predicting cortical bone resorption in the mouse tibia under disuse conditions caused by transient muscle paralysis
Large language model driven transferable key information extraction mechanism for nonstandardized tables
Comparative evaluation of adaptation and fracture resistance of CAD-CAM fabricated zirconia posts in endodontically treated teeth
Prevalence and determinants of antidepressant non-adherence among patients with major depressive disorder in Ethiopia: a multi-center cross sectional study
Abstract Non-adherence to antidepressant medication is a well-established factor contributing to treatment failure among patients with major depressive disorder. Addressing this issue is crucial not only for enhancing individual patient outcomes but also for alleviating the broader public health burden. The study aimed to assess antidepressant medication non-adherence and its determinants among patients with major depressive disorder at public hospital psychiatric clinics in Ethiopia. Between June 12, 2024, and November 13, 2024, a multicenter cross-sectional study was conducted at public hospital psychiatric clinics in Ethiopia. Antidepressant non-adherence was assessed using a self-reported tablet count tool with pharmacy refill records available in patients’ charts at the time of the interview. The severity of adverse drug reactions (ADRs) was evaluated using the Antidepressant Side-Effect Checklist (ASEC), while the Naranjo ADR Probability Scale was employed to determine the likelihood of ADRs. Data analysis was performed using SPSS version 26.0. Frequencies and percentages, were used to describe the characteristics of study participants. For factors associated with antidepressant non-adherence, multivariate logistic regression was conducted. The association between explanatory variable and non-adherence was assessed using odds ratios (ORs) with 95% CIs. The prevalence of antidepressant medication non-adherence was 139 (32.9%). Female gender [AOR = 3.29, 95% CI (2.04, 5.31)], illiteracy [AOR = 2.17, 95% CI (1.35, 3.50)], unemployment [AOR = 3.40, 95% CI (2.15, 5.38)], treatment duration greater than 25 months [AOR = 1.89, 95% CI (1.05, 3.41)], and severe ADRs [AOR = 3.94, 95% CI (1.68, 9.23)] were significantly associated with Antidepressant medication non-adherence. Being female, illiterate, unemployed, having a treatment duration of more than 25 months, and experiencing severe adverse drug reactions were significantly associated with non-adherence. These findings highlight the need for targeted interventions to improve adherence among these high-risk groups.