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Psychometric validation of the VIP care battery and composite scale for vulnerable populations inclusiveness in pharmaceutical care
Role of social competence in emotion processing among emerging adults with anxiety
Retention of 2011 Fukushima Dai-ichi NPP accident-derived 137Cs in the northern North Pacific–Bering Sea
Kraak porcelain decorative pattern restoration using generative AI: a pilot study
A new coelacanth (Actinistia, Sarcopterygii) from the Early Triassic of Anhui, China
Targeted proteomics analysis in type 1 diabetes identifies lower agouti-related protein levels in individuals with impaired hypoglycaemia awareness
Rituximab therapy in patients with treatment-refractory hypersensitivity pneumonitis
Abstract Hypersensitivity pneumonitis (HP) presents with a highly variable clinical course, and traditional treatment includes systemic corticosteroids and strict antigen avoidance. The objective of this study was to evaluate the therapeutic potential of Rituximab in patients with progressive hypersensitivity pneumonitis who do not respond to antigen avoidance and conventional immunosuppressive therapy. In this cohort prospective study, 30 patients with refractory HP were enrolled. Forced Vital Capacity (FVC) was assessed at three time points: six months before Rituximab initiation (M − 6), at treatment initiation (M0), and six months later (M + 6). FVC% predicted significantly declined from (58.57 ± 10.9) at M − 6 to (51.03 ± 11.06%) at M0 [p < 0.001], but showed a minimal, non-significant drop to 50.1 ± 12.7% at M + 6 [p = 0.405]. The rate of decline slowed markedly post-Rituximab, from − 7.54% (M − 6 to M0) to − 0.93% (M0 to M + 6). Dyspnea, measured by the mMRC scale, improved from 2.77 ± 0.5 at M0 to 1.83 ± 0.85 at M + 6 [p = 0.001]. 6MWD also increased from 258.67 ± 77 m to 307 ± 99 m [p = 0.001]. There were no reported cases of mortality. Rituximab demonstrates potential as an emerging therapeutic option for patients with treatment-refractory hypersensitivity pneumonitis and is well-tolerated. Trial registration: Retrospectively registered, registration number is NCT07035561, date of registration 16/06/2025.
Spatio-temporal patterns, trends, and oceanographic drivers of whale shark strandings in Indonesia
Abstract Despite the increased international attention to whale shark conservation, their populations remain predominantly depleted due to anthropogenic activities such as fishing, ship collisions, and marine pollution. Reports of whale shark strandings in Indonesia have been increasing in recent years, elevating concerns regarding their well-being and the potential disturbance to their population recovery. However, limited understanding of stranding patterns, trends, and the oceanographic factors potentially driving these events has resulted in efforts focusing primarily on responding to strandings rather than implementing effective mitigation strategies. Using a 13-year stranding dataset ( n = 115) obtained from open-access databases, reports, news, and publications, we examined the characteristics of stranding cases in Indonesia, including population demographics, where hotspots occur, and whether their occurrence is related to oceanographic dynamics in the region. Our study highlights significant population-level disturbances, with 70% of stranded individuals being large juveniles (4–7 m). It also documented a positive interannual trend in stranding cases (R² = 0.67, p < 0.01). The southern coast of Java has emerged as a stranding hotspot, with events seasonally associated with strong upwelling, likely related to the seasonal foraging activities of whale sharks in the region. Although natural events were identified as the main factors contributing to whale shark strandings, anthropogenic activities may also play an important role and require further investigation.
Perceptions of targeted sexual healthcare among French MSM based on HPV vaccination policy in France
HSP90/PUS7/THUMPD1 promotes metastasis and cisplatin resistance in gastric cancer cells
KLF2 may suppress chicken adipogenesis by enhancing the GATA2 transcription
Periodontal markers predict glycemic control in diabetic patients a ten year retrospective analysis
A comparison of the performance of Chinese large language models and ChatGPT throughout the entire clinical workflow
Optimizing short video strategies for intelligent communication in university campus culture construction using circular intuitionistic fuzzy COCOFISO modeling
Machine learning-based detection and mitigation of cyberattacks in adaptive cruise control systems
In-cell NMR spectra of chemically unmodified RNA at physiological temperature with extended lifetime through RNase inhibitor cocktail in living human cells
Tailoring the compressive properties of 3D printed composites using bioinspired micro/macrostructure designs
Hybrid GA-SQP neural network frame for solving english language learning
Interindividual differences in auditory processing moderate the effect of auditory-motor coupling on paired-associate learning
Abstract The present study explored the effects of auditory–motor coupling and individual differences in pitch perception on verbal learning. Participants (N = 47) learned a list of foreign-language vocabulary word pairs under isochronous or self-initiated auditory stimulation while cycling on a stationary bike. As expected, better movement consistency—i.e., lower cycling variability and more stable synchronization with the vocabulary presentation—was weakly associated with improved memory performance. Interestingly, we found inter-individual differences in the pattern of results: participants with fundamental pitch perception (FPP) benefited from isochronous stimulation immediately after learning (Day 1), but not after overnight consolidation (Day 2), whereas participants with spectral pitch perception (SPP) showed a long-term memory benefit from isochronous stimulation. This suggests that auditory processing characteristics modulate whether isochronous input supports early encoding or later consolidation. Furthermore, musically experienced participants showed more variable pedaling in the self-initiated condition, possibly reflecting deliberate modulation of input timing. In contrast, isochronous stimulation reduced variability across all participants, indicating implicit synchronization even without an explicit instruction to synchronize. Overall, these findings highlight the role of individual auditory and motor traits in shaping the cognitive benefits of sensorimotor coupling during learning.