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Influence of bedding angles on dynamic properties of Yanchang shale and a DIF-based constitutive model
ADIPOQ regulates lipid metabolism by activating AMPK/CPT-1 pathway to attenuate the proliferation of psoriasis lesions
Design, biological evaluation, solvatochromic, DFT, and molecular docking studies of new metal complexes derived from a semicarbazone ligand
Abstract The current study describes the synthesis and characterization of novel Ni(II), Co(II), and Fe(III) complexes of the semicarbazone ligand (ACMHCA). Spectroscopic, conductance, elemental, and magnetic studies confirmed octahedral geometries. Solvatochromic fluorescence analyses, supported by DFT/TD-DFT calculations, revealed higher excited-state dipole moments indicating increased polarity upon excitation. Among the complexes, Co(II)-ACMHCA displayed the highest polarizability and hyperpolarizability, suggesting potential in optoelectronics. Biological assays demonstrated notable antimicrobial and anticancer activities, with docking studies confirming strong receptor binding. These findings highlight the therapeutic and functional potential of ACMHCA-based metal complexes.
Machine-learning ensembled probabilistic methods for time-dependent reliability analysis of reservoir slopes under rapid water level drawdown using Bayesian model averaging (BMA)
Development and cross-amplification of novel SSR markers for population genetic analysis of Kitti’s hog-nosed bat (Craseonycteris thonglongyai) in Thailand
Midterm cardiovascular outcomes in children with MIS-C compared to Kawasaki disease: a multicenter prospective cohort study
Fracture propagation and water seepage behavior in overburden strata at Tunbao coal mine
Abstract This study investigates water inrush mechanisms in goaf roof strata through multi-scale analysis of fracture network evolution and seepage dynamics. A three-zone overburden model was established via PFC3D simulation and validated with experimental data. Coupled PFC-CFD simulations reveal that seepage is governed by the interplay of pressure gradients, fracture pathways, and flow rates. Key findings include: nonlinear attenuation of pressure gradients amplifies flow velocities in dominant channels; increased injection rates widen effective channels by 86%; and high-velocity flow enhances permeability through erosion, resulting in significant directional anisotropy. These results provide insight into the positive feedback mechanisms controlling dynamic seepage in fractured rock masses.
Attention-Base deep learning for 3D craniofacial soft tissue landmark detection and diagnosis in orthodontics
Well-to-well transfer of HaloTag ligand 6-chlorohexan-1-ol and formaldehyde in a multi-well plate
Abstract When volatile organic compounds are handled in multi-well plates, their volatilization is known to affect non-treated wells in the plate. In this paper, we report two cases in which the HaloTag ligand 6-chlorohexan-1-ol and formaldehyde were volatilized and transferred to other wells in a multi-well plate. We found that competition between the HaloTag-targeting PROTAC and 6-chlorohexan-1-ol affected the other wells of the plate. A multifaceted analysis revealed that this phenomenon resulted from well-to-well transfer of 6-chlorohexan-1-ol into untreated wells on the plate. In addition, the formaldehyde used for cell fixation was toxic to cells in the surrounding wells. Therefore, even these reagents, which are widely used in life science research, require careful handling in multi-well plates.