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Machine learning-based mortality risk prediction model for elderly diabetic patients with non-ST-segment elevation myocardial infarction using MIMIC-IV database
Ceftazidime prescription and antibiotic resistance patterns in a tertiary care hospital
Global diet quality score (GDQS) favorably affects blood pressure, serum lipids, lipid accumulation product and attenuates inflammation among obese individuals
Analyzing the effects of benzodiazepines on the virulence and biofilm formation of Pseudomonas aeruginosa
Multi-cohort evidence linking edentulism to frailty among older adults
Abstract To investigate the association between edentulism and frailty across nationally representative cohorts in China, the United Kingdom, and the United States. A harmonized analysis was conducted using longitudinal data from the CHARLS, ELSA, and HRS cohorts. This study examined the association between self-reported edentulism (exposure) and frailty (outcome), with adjustment for self-reported covariates including age, gender, lifestyle factors, and comorbidities. Multivariable linear and logistic regression models were applied to examine the associations of edentulism with the frailty index and frailty phenotype, respectively. To synthesize effect estimates across cohorts, fixed- and random-effects meta-analyses were conducted. Robustness was assessed through stratified analyses by age and gender, as well as through multiple imputation to address missing data. A total of 9,869 participants from CHARLS (female: 52.9%, mean age: 61.2 years), 5,083 from ELSA (female: 55.7%, mean age: 62.7 years), and 12,322 from HRS (female: 59.5%, mean age: 65.8 years) were included. Meta-analysis of the fully adjusted models across cohorts revealed that edentulous individuals exhibited significantly higher frailty index scores (pooled mean difference = 2.68; 95% confidence interval [CI]: 1.67–3.69) and increased odds of frailty status (pooled odds ratio = 1.38; 95% CI: 1.26–1.50) compared to dentate counterparts. These associations remained robust in stratified and sensitivity analyses. Edentulism is independently associated with frailty across aging populations. These findings underscore the clinical relevance of oral health in geriatric risk assessment and support the integration of dental evaluation into multidisciplinary strategies for frailty management.
Triaxial test investigation of the reinforcement effect of Acacia dealbata roots on mountain red soil
Ferroptosis and autophagy-related genes contribute to hypertrophic cardiomyopathy progression
FL-MalDrift: a federated learning framework for malware detection under local concept drift
Long-term exposure to ambient air pollution and incident cardiovascular disease in adults with cardiovascular–kidney–metabolic stages 0–3: a nationwide prospective cohort study in China
Evolutionary adaptation of anaerobic and aerobic metabolism to high sulfide and hypoxic hydrothermal vent crab, Xenograpsus testudinatus
Silent cerebral microvascular disease and the longitudinal risk of cognitive decline in atrial fibrillation
Exploratory insights into salivary E-cadherin as a non-invasive biomarker in a rat model of diabetes
A text guided multimodal scale path fusion network for multimodal sentiment analysis
Mitigating catastrophic forgetting in lifelong learning: a hybrid architecture integrating neural ordinary differential equations with memory-augmented transformers
Retraction Note: Effects of the TLR4 signaling pathway on apoptosis of neuronal cells in diabetes mellitus complicated with cerebral infarction in a rat model
Identification of competing endogenous RNA networks involved in phrenic nerve stimulation preventing mechanical ventilation induced diaphragm dysfunction
Exploring stationary phase morphologies as pathways to greener and faster LC for analyzing sofosbuvir and ledipasvir
Abstract Green chemistry has a beneficial influence on the environment and the pharmaceutical enterprises’ economy. Research and quality control laboratories worldwide conduct millions of analyses daily, employing liquid chromatography as the primary analytical technique. Furthermore, advancements in stationary phase technologies aimed at achieving faster and more efficient separations have introduced a new objective for chromatographers. This objective is to supersede conventional methodologies that rely heavily on substantial quantities of organic solvents, pose environmental hazards and incur considerable economic costs. The aim of this work is to provide a brief comparison between monolithic, core-shell and traditional fully porous stationary phases. This could help analysts by offering options for high-speed versus high-resolution separation when choosing the best packing materials. The analytes used in the study are two essential drugs used in the treatment of hepatitis C virus: Sofosbuvir and Ledipasvir, which are co-formulated in tablet dosage forms. The monolithic column enabled the fastest analysis, whereas the core-shell provided the highest efficiency. Validation was conducted in accordance with ICH guidelines using the RP-C18 monolithic column, a mobile phase consisting of 0.1% acetic acid and ethanol (60:40), a flow rate of 1 mL.min − 1 , and detection at 210 nm. The total analysis time did not exceed 3 min, achieving high accuracy and sensitivity while minimizing the use of hazardous solvents. It achieved a very good score on different green analytical chemistry assessment metrics; 0.7 on AGREE, 76 on MoGAPI, 80 on BAGI, and 73 on CACI.