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Future-aware blood glucose forecasting using knowledge distillation with transformer-based sequence-to-sequence models
MALDI-TOF mass spectrometry imaging of sulfatide lipid expression in the CNS of mice with experimental autoimmune encephalomyelitis
Computation of sentence similarity score through hybrid deep learning with a special focus on negation sentence
A BIM-simulated annealing approach to optimize cost, size, and environmental impact of building water networks
Research on dynamic stiffness match form of indirect fastener based on rail high-frequency wear characteristics
Ecosystem structure influences human health outcomes as the basis for green prescriptions
Effectiveness of endovenous ablation techniques and surgery for great saphenous vein incompetence: a comprehensive meta-analysis of randomized controlled trials
Whole exome sequencing and 12-SNP LDL polygenic score in South Indian patients with familial hypercholesterolemia
Pyrogallol B-ring enhances catechin binding to the SARS-CoV-2 spike receptor-binding domain to inhibit interaction with ACE2
Abstract Severe acute respiratory syndrome coronavirus 2 infects host cells through binding of the spike protein receptor-binding domain (RBD) to the human angiotensin-converting enzyme 2 receptor. In this study, the antiviral activity of 14 catechin derivatives was evaluated using a pseudovirus assay that emulates spike-mediated cell fusion. Of these, gallocatechin gallate, epigallocatechin gallate, epigallocatechin 3-(3″-O-methyl) gallate, and epigallocatechin exhibit strong inhibitory effects on infection. A structural comparison of the compounds revealed that catechins with a pyrogallol-type B-ring configuration exhibited greater inhibitory effects than their catechol-type counterparts. Docking simulations demonstrated that the hydroxyl group at the 5-position of the B-ring forms a hydrogen bond with Gln493 on the spike RBD, thereby facilitating additional stabilizing interactions with adjacent residues, such as Tyr453. Although catechin bioavailability is low, the results of this study suggest that regular consumption or gargling may offer localized antiviral activity at mucosal surfaces, such as those found in the oral or nasal cavity, because the catechin concentrations used in the cell assays are similar to those observed in green tea (100 µM). This study underscores the potential of pyrogallol-type catechins to act as antiviral agents.
A bio-polymeric strategy for enhancing the strength, durability of concrete and shrinkage reduction
A comprehensive nationwide registry study of noncommunicable disease comorbidities and death in cancer patients in Norway—the NCDNOR project
Abstract Noncommunicable disease (NCD) comorbidities are common in cancer patients due to shared risk factors, but few studies have mapped their occurrence across cancer types using detailed national data. In this nationwide cohort study, we used data from Norwegian mandatory health registries to comprehensively describe NCD comorbidities at and after cancer diagnosis of 19 cancers. We included 269,956 adults registered with a first cancer in the Cancer Registry of Norway 2009–2019. Comorbidities included second cancers, cardiovascular diseases (CVDs), chronic obstructive pulmonary disease, diabetes and mental health disorders (MDs). We used intersection diagrams to examine NCD comorbidity patterns at first cancer diagnosis, and multi-state models to estimate five-year post-cancer probabilities of NCD comorbidities and death. We also provide a publicly available online application [ https://ncdapp.onrender.com/ ] with additional results and details. Comorbidity prevalence at cancer diagnosis ranged from 35% (skin cancer) to 83% (lung cancer). CVD was most prevalent, usually co-occurring with MDs or diabetes. Lowest prevalences were found for younger patients and women. Conditioning on surviving five years, comorbidity probability exceeded 50% in all sites. Our findings show substantial comorbidity burden in cancer patients, varying by cancer site, age, and sex. Knowledge of these patterns could improve NCD prevention, treatment and surveillance.
GTPBP2 inactivates Hippo signaling to promote triple-negative breast cancer cell malignancy
Anatomical and physiological traits to identify low-vigor Persian walnut accessions as candidate dwarfing rootstocks
Switching single and dual wavelength emission in a quasi-three-level Nd: YLF laser by adjusting pump beam waist position
A geometric morphometrics approach to sex estimation of infants from 0 to 6 years using the auricular surface
Abstract Estimating biological sex is an essential tool for studying past population dynamics and cultural behaviour. Typically, it is not performed in non-adults before the onset of puberty, limiting the knowledge that can be gained from immature skeletal remains. This study used three-dimensional (3D) geometric morphometrics (GM) to examine sexual dimorphism and assess its effectiveness in estimating biological sex in infants aged 0–6 years using the auricular surface of the ilium. This approach was tested with 46 individuals (20 females and 26 males) from the Lisbon Identified Skeletal Collection. All specimens were digitised, and standard GM analysis was conducted. Apparent sex-related morphological differences in the auricular surface were observed in infants under one year, although these did not reach statistical significance at α = 0.05. Such differences were not identified in older individuals. These findings suggest that the auricular surface may potentially serve as a sex indicator in infants under one year, whereas sexual dimorphism appears to decrease in older individuals. This study demonstrates the potential of employing 3D GM for sex estimation in non-adult skeletal remains. Further research should explore additional iliac features for infant sex estimation, incorporate larger and more diverse samples, and potentially include Artificial Intelligence techniques.
A stress-controlled reservoir formation model for ultra-deep sandstones in foreland thrust belts: case study of the cretaceous bashijiqike formation, bozi-dabei area, kuqa depression, tarim basin
Predicting infected pancreatic necrosis in acute pancreatitis using machine learning models and feature selection
Explainable and secure federated learning for privacy-enhancing skin cancer classification using a lightweight multi-scale CNN
The effect of unilateral cortical blindness on lane position and gaze behavior in a virtual reality steering task
Abstract Adults with cortically-induced blindness (CB) affecting a quarter to a half of their visual field show greater variability in lane positioning when steering compared to those with intact vision. Because humans rely on visual information from optic flow to control steering, we hypothesized that these lane biases are caused in part by a disruption to motion processing caused by CB. To investigate, we examined the steering behavior of 21 CB drivers (11 left-sided, 10 right-sided visual deficits) and 9 visually intact controls in a closed-loop virtual reality steering task. Participants were instructed to maintain a central lane position while traveling at 19 m/s along a procedurally generated single-lane road. Turn direction (left/right) and turn radius (35m/55m/75m) varied between trials, and the quality of optic flow information was indirectly manipulated by altering the environmental texture density (low/medium/high). Right-sided CB participants maintained a similar average distance from the inner road edge as controls. Those with left-sided CB were less affected by changes in optic flow and turn direction. These differences were not explained by age, time since stroke, sparing of central vision, gaze direction, or saccade rate. Our results suggest that some left-sided CB participants place a lower weighting on optic flow information in the control of steering, possibly as a result of lateralization in the processing of motion. More broadly, our findings show that CB steering and gaze behavior are remarkably preserved despite the presence of visual deficits across large portions of the visual field.