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Nitrate-Sialin2 axis couples ER-mitochondrial calcium signaling with fatty acid metabolism to drive white adipose browning

Effect of a mobile-based resilience training program on resilience and well-being outcomes in individuals with chronic pain

Tunable magnons in a dual-gated 2D antiferromagnet

Abstract The layered antiferromagnet CrSBr features magnons coupled to other quasiparticles, including excitons and polaritons, which enables their easy optical accessibility. In this work, we investigate the response of the magnons in few-layered devices to changes in carrier density and an applied perpendicular electric field. While the frequencies of both modes increase with the electron density, we reveal their asymmetric response with respect to the electric field. To understand the mechanism of this disparity, we propose a layer-resolved macrospin model describing the magnetic dynamics in thin, non-uniformly doped devices. Through this model we establish the dominant dependencies of the interlayer exchange interaction, magnetic anisotropy, and magnetic moment on the electron density and electric field in individual layers. We demonstrate an on-chip tunability of the in- and out-of-phase magnon frequencies by up to 2 GHz in a dual-gated trilayer device. Our results advance the applications of gate-tunable magnonic devices based on 2D materials.

School and family based myopia education associations with myopia prevalence in Hefei high school students in the post-COVID-19 period

Late-stage generation of 14C/3H-radiolabeled lysine residues via hydroformylation of peptides

Abstract Peptides constitute a well-established and rapidly expanding field in the contemporary pharmaceutical drug landscape. Studies with 14 C- or 3 H-radiolabeled analogs are the gold standard for drug development, yet access to 14 C-peptides is costly and limited to derivatization of the native structure with tags or lengthy multi-step syntheses. In this work, we report a platform that installs 14 C- or 3 H-radiolabeled lysine residues directly on solid-supported peptides. The workflow constitutes a mild, peptide-compatible hydroformylation process of allylglycine residues to generate labeled allysine, followed by reductive amination that furnishes radiolabeled lysine residues directly upon cleavage from the solid support. The hydroformylation setup can be tuned for flexible isotope introduction by using 14 CO from solid precursors and 3 H 2 from standard tritium manifolds. We show that the optimized workflow tolerates diverse sequences and enables functionalization of peptides as complex as semaglutide analogs.

Influence of H+ on CO2 solubility during carbonate acidizing

Artificial intelligence-powered cloud security strategies for protecting critical clinical operations in healthcare environments

Conserved genetic and antigenic profiles of Pf12 and Pf41 in asymptomatic Plasmodium falciparum carriers in Tanzania

A collaboration mechanism for medical insurance settlement based on isolation forest and Fleiss kappa smart contract

Identification of PI3K alpha inhibitors through large-scale virtual screening and integrated molecular modeling, biophysical characterization, and ADMET profiling

Evolution of overlying strata and disaster-causing mechanisms under inclined thin coal seam group mining: insights from numerical simulations

Abstract To clarify the overburden evolution and asymmetric instability mechanism during bottom-up repeated mining of an inclined thin coal seam group, a 3DEC numerical model was established based on geological conditions in Guizhou Province. The caving behavior, stress redistribution, displacement response, and simulated fracture-trace complexity of the overlying strata were analyzed during the first mining (M1), second mining (M2), and third mining (M3) stages. The results show that M1 mining mainly induces local subsidence, goaf compaction, and limited fracture development. With the successive extraction of M2 and M3, interlayer disturbance is progressively superimposed, the overburden failure range expands upward, and the stress field evolves into a zoned pattern characterized by stress relief in the goaf and stress concentration near the working face and goaf boundaries. The displacement field also shows a cumulative response, with the high-displacement zone migrating upward and the subsidence trough becoming deeper and wider. Under the 30° inclined structure, overburden deformation and failure exhibit clear dip-direction asymmetry: the high side is dominated by separation, sliding, and fracture development, whereas the low side mainly shows compaction and constrained deformation. The apparent fractal dimension of simulated fracture traces increases from 1.023 at M1 to 1.096 at M2 and 1.144 at M3, indicating enhanced relative complexity under identical discretization conditions. The overburden hazard-causing mechanism is therefore interpreted as a coupled process of stress redistribution, uncoordinated subsidence, high-side fracture development, and asymmetric instability of the load-bearing structure. These findings provide guidance for roof stability assessment and hazard control in inclined thin coal seam group mining.

Effects of dissolved surfactants in carbonated water on swelling factor and interfacial tension under sub and supercritical conditions using synthetic resinous and asphaltenic oil

Performance of CNT-enhanced GGBS/fly ash concrete for precast U-drain applications

Sustainable Ag–Cu bimetallic nanozymes derived from Juglans regia husk exhibit multifunctional catalytic, antimicrobial, and antioxidant activities

A study on cable current detection for new energy charging stations based on TMR sensor arrays

Seasonal and environmental patterns of naturally occurring parasitoids with potential to attack the invasive pest Drosophila suzukii in the Andes

Enzyme-aware soil fertility prediction using dual optimization with improved SCSO

Sequence-based prediction of drug–target binding using machine learning, deep learning and ensemble models without 3D structural information

CA1 parvalbumin interneurons display alterations of myelin patterning driven by microgliosis in temporal lobe epilepsy

Early cell-wall stress signatures enable 20-min ATR-FTIR discrimination of MRSA and MSSA