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Polar bears and expanding sea ice in the Mid Holocene Aleutian Islands, Alaska
Parallel robotic automated docking method for realizing space segment assembly
Adverse obstetrical outcomes among adolescents in North Wollo Zone Governmental hospitals, Northern Ethiopia
Management of cardiovascular disease by cerium oxide nanoparticles via alleviating oxidative stress and adipokine abnormalities
Abstract The current study aimed to evaluate the role of cerium oxide nanoparticles (C-1), a potent antioxidant, in the medication of cardiovascular disease in obese animal model. C-1 was prepared using a modified sonication sol-gel method. Thirty-two adult male rats were equally divided into 4 groups (n=8/each). The first (control) and second (obese) groups are not treated while the obese rats in the third and fourth groups were given 15 and 30 mg/kg C-1(IP), respectively, for 8 weeks. Parameters of insulin resistance, adipocyte hormones, inflammatory markers, lipid profile, cardiac enzymes and cardiac iron content (C-Fe) were estimated. Moreover, histological study and immunohistochemical stain for inducible nitric oxide synthase (INOS) for cardiac and aortic tissues were performed. The XRD patterns of C-1 showed narrow symmetric diffraction peaks. The particle diameters were calculated from the TEM histogram (21.09 nm) and the Debye-Scherrer Method (20.74 nm) which were very similar. Using the most intense peak ( $$28.47^{\circ }$$ 28 . 47 ∘ ), structural parameters were calculated including nano-crystallite size, Micro-strain, Lorentz factor, Thomson polarization parameter, and Lorentz polarization parameter. BET was used to calculate The total surface area (S $$_{T}$$ T ), and specific surface area (S $$_{BET}$$ BET ). The XPS survey spectrum of C-1 showed peaks for C-1s, O-1s and Ce-3d. The treatment of obese rats with C-1 led to a significant decrease in body weight, C-Fe , plasma leptin, tumor necrosis factor-alpha (TNF $$\alpha$$ α ), interleukin-6 (IL6), C-reactive protein (CRP), resistin, cholesterol, triglycerides, low-density lipoprotein (LDL), Troponin, Creatinine Kinase-MB (CK-MB), lactate dehydrogenase (LDH), and malondialdehyde (MDA) in cardiac tissue or in plasma. Also, C-1 lowered plasma monocyte chemoattractant protein-1 (MCP-1), Epithelial Neutrophil-Activating Peptide (ENA-78), and insulin and glucose levels in obese rats. Furthermore, C-1 alleviated the increase of cardiac iNOS. Moreover, C-1 mitigated pathological changes of cardiac muscle and aorta observed in obese rats. On the other hand, C-1 enhanced adiponectin, cardiac glutathione (GSH) and superoxide dismutase (SOD) in obese rats. The effect of C-1 is dose-dependent ( 30 mg/kg of C-1 is more evident than 15 mg/kg). The modified synthesis method may lead to a smaller particle size than that reported in our previously reported work. The XRD patterns of C-1 indicate its cubic structure with space group F m -3 m (225) which was matched by code id 4343161 from COD. The Raman spectrum of C-1 indicates the absence of rearrangement oxygen atoms, the presence of oxygen in its fluorite lattice positions, and the oxygen vacancies in C-1 and the Ce vibration model (F2g). The presence of ten peaks in the high-resolution Ce-3d XP spectrum indicates the existence of both Ce3+ and Ce4+. C-1 showed therapeutic efficacy in atherosclerosis and cardiac muscle abnormalities associated with obese rats, probably because of their antioxidant and anti-inflammatory properties, which lead to lowering oxidative stress.
Diagnostic performance of S100B assay for intracranial hemorrhage detection in patients with mild traumatic brain injury under antiplatelet or anticoagulant therapy
Prediction and assessment of optimal concrete compositions for overall radiation protection and reduced global warming potential
A unified framework harnessing multi-scale feature ensemble and attention mechanism for gastric polyp and protrusion identification in gastroscope imaging
Investigating the causal relationship between the plasma lipidome and cholangiocarcinoma mediated by immune cells: a mediation Mendelian randomization study
Single–dose methylphenidate induces shift in functional connectivity associated with positive longer term clinical response in adult attention–deficit/hyperactivity disorder
Diabetes mellitus and its determinants among tuberculosis patients in South Gondar Zone health facilities, Northwest Ethiopia
Numerical study of coal reservoir and borehole parameters evaluation considering temperature and multi-borehole superposition effects
The Big Bang of an epidemic: a metapopulation approach to identify the spatiotemporal origin of contagious diseases and their universal spreading pattern
Abstract In this paper, we propose a mathematical framework that governs the evolution of epidemic dynamics, encompassing both intra-population dynamics and inter-population mobility within a meta-population network. By linearizing this dynamical system, we can identify the spatial starting point(s), namely the source(s) and the initiation time of the epidemic, which we refer to as the “Big Bang” of the epidemic. Furthermore, we introduce a novel concept of effective distance to track disease spread within the network. Our analysis reveals that the contagion geometry can be represented as a line with a universal slope, for any disease type (R0) or mobility network configuration. The mathematical derivations presented in this framework are corroborated by empirical data, including observations from the COVID-19 pandemic in Iran and the US and the H1N1 outbreak worldwide. Within this framework, to detect the Big Bang of an epidemic we require two types of data: (1) A snapshot of the active infected cases in each subpopulation during the linear phase. (2) A coarse-grained representation of inter-population mobility. Also even with access to only the first type of data, we can still demonstrate the universal contagion geometric pattern. Additionally, we can estimate errors and assess the precision of the estimations. This comprehensive approach enhances our understanding of when and where epidemics began and how they spread. It equips us with valuable insights for developing effective public health policies and mitigating the impact of infectious diseases on populations worldwide.
Electrochemical determination of uric acid in the presence of dopamine and riboflavin using a poly(resorcinol)-modified carbon nanotube sensor
IR thermography & NN models for damaged component thickness detection
Comparative analysis of the effects of Nano-SiO2 and carbon nanotubes on mechanical properties of polyethylene fibre reinforced cementitious composites
High-performance terahertz biosensor utilizing a hybrid one-dimensional photonic crystal with liquid crystal and graphene components
Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients
Prosopagnosia and the role of face-sensitive areas in race perception
α-spinasterol isolated from Achyranthes aspera L. ameliorates inflammation via NF-κB and Nrf2/HO-1 pathways
Abstract On the basis of previous studies, the low-polar part of Achyranthes aspera L. (A. aspera) had strong anti-inflammatory activity. Three compounds were isolated from the low polarity fraction of A. aspera, and their structures were identified as α-spinasterol (1), 7,8-dihydrospinasterol (2), 22,23-dihydrospinasterol (3). Among them, the content of α-spinasterol (1) in A. aspera was higher in the spring and winter seasons through HPLC methods, ranging from 0.0085 to 0.0157%. Futhermore, in the LPS-induced RAW264.7 cells inflammation model, α-spinasterol significantly reduced the levels of cytokines such as IL-6, PGE2 and TNF-α, inhibited the expression of COX-2, 5-LOX, p-IKKβ, p-NFκB and p-IkBα proteins, and promoted the expression of Nrf2, HO-1 and NQO1 proteins. Therefore, this study showed that α-spinasterol can inhibit LPS-induced RAW264.7 cells inflammation, and its mechanism may be related to the inhibition of NF-κB pathway, activation of Nrf2 pathway, and reduction of excessive release of inflammatory factors.