Browse Articles

Abstract MP28: Healthy Eating for the Planet, Cardiovascular Health, and Longevity: An Observational Study

Introduction: There is insufficient evidence on the impact of the environmentally sustainable diet proposed by the EAT- Lancet Commission on cardiovascular disease (CVD) and mortality in the US population. Methods: Dietary intake was assessed by a 66-item food frequency questionnaire at visit 1 (1987-1989) and visit 3 (1993-1995) in the Atherosclerosis Risk in Communities (ARIC) study. The Planetary Health Diet Index (PHDI) was used to assess adherence to the EAT -Lancet reference diet. Incident CVD was a composite outcome of coronary heart disease (CHD), stroke, and heart failure. CVD mortality and all-cause mortality were defined as deaths based on International Classification of Diseases codes and National Death Index. Participants were followed until December 31, 2021. Associations between PHDI and CVD outcomes and mortality were analyzed using Cox proportional hazards models and adjusted for covariates. Results: In 13,095 US adults, participants in the highest quintile of PHDI had a lower risk of total CVD (HR 0.84; 95%CI 0.77, 0.93; P -trend < 0.001) in the multivariable-adjusted model, compared with those in the lowest quintile ( Figure ). The inverse association was consistently observed across CVD subtypes (CHD: HR 0.83; 95%CI 0.72, 0.96; P -trend = 0.007; stroke: HR 0.77; 95%CI 0.65, 0.92; P -trend = 0.003; heart failure: HR 0.87; 95%CI 0.78, 0.98; P -trend = 0.01). Participants in the highest versus lowest quintile of PHDI had a 16% and 13% lower risk of CVD mortality and all-cause mortality, respectively (both P -trend < 0.005). Conclusions: Higher adherence to PHDI was consistently associated with a lower risk of total CVD, CVD subtypes, CVD mortality, and all-cause mortality in a general population of US adults.

Towards an intelligent integrated methodology for accurate determination of volume percentages in three-phase flow systems

Abstract P2100: Longitudinal association between MIND diet adherence, inflammatory mechanism, and cognitive health

Introduction: Evidence is limited on the cognitive benefits of the Mediterranean-DASH Intervention for Neurodegenerative Delay(MIND) diet and biological mechanism for middle-age adults. We examined the longitudinal association of MIND diet with cognitive change over time and whether the association was mediated by reduced inflammation. Hypothesis: A higher MIND diet score, indicating better adherence to the dietary pattern, was associated with slower cognitive decline, and inflammation—measured by circulating inflammatory biomarkers—mediated the association. Methods: This study included data from 3,515 participants of the 2013 Health Care and Nutrition Survey (HCNS), a subsample of the Health and Retirement Study, who were over 50 years of age, were without probable dementia at the baseline in 2012, and had self-reported cognitive measures between 2012 and 2020, MIND diet score, and key demographics. Inflammatory biomarkers included C-reactive protein (CRP), tumor necrosis factor receptor (TNFR1), and Insulin-like growth factor 1 (IGF-1). Change in cognition were estimated using linear mixed effects models. All models were adjusted for age, sex, race/ethnicity, educational attainment, household income, and presence of APOE e4 allele. Results: Over half of the respondents were aged 65 years and older (51.7%) and female (54.7%). At baseline, compared to the low tertile, higher adherence to MIND diet was associated with better cognitive score [middle tertile: β(SE)=0.41(0.12); high tertile: β(SE)=0.66 (0.16), p <0.001], lower levels of CRP ( p <0.001) and TNFR1 ( p <0.001), and higher level of IGF1 ( p <0.001); higher TNFR1 was associated with worse cognitive scores [β(SE)=-0.038(.17), p <0.029]. TNFR1 mediated 16.02% of the total effect of the MIND diet on cognitive function (indirect β = 0.11, 95% CI [0.08, 0.15]). During the 8-year follow-up, participants in the higher tertile of MIND diet had a slower rate of cognitive decline over time compared to those in the low tertile [low: β(SE)=-0.24(0.023); middle: β(SE)=-0.19(0.023); high: β(SE)=-0.11 (0.028)], p <0.001. The association between MIND diet and cognitive change was attenuated—7.90% for the high tertile—after including TNFR1. Conclusions: Following a healthy MIND dietary pattern at middle-age can help slow down cognitive decline, which occurs at least partially through mitigating the TNFR1-related inflammation pathway.

Abstract P3059: Exploring Genetic Ancestry, Socioeconomic and Acculturation Factors in Hispanic/Latino Hypertrophic Cardiomyopathy Genotype Carriers: Insights from the Hispanic Community Health Study / Study of Latinos (HCHS-SOL)

Introduction: Hypertrophic Cardiomyopathy (HCM) is associated with rare sarcomeric variants. Little is known about the profiles of HCM sarcomeric variant carriers in diverse populations, particularly in Hispanic/Latino (H/L) individuals. Methods: We examined whole-genome sequencing data from the Hispanic Community Health Study to evaluate sarcomeric gene variants within a large diverse H/L cohort. HCM variant carriers were identified by the presence of nonsynonymous deleterious variants (category D) in eight sarcomeric genes (MYBPC3, MYH7, TNNT2, TNNI3, MYL2, MYL3, TPM1, ACTC1), predicted using the PolyPhen-2 HumDiv model. Acculturation, socioeconomic variables and genetic ancestry proportions were analyzed across HCM variant carrier status, with sampling weights applied to generate weighted means, frequencies, and population estimates. Genetic ancestry was only assessed among genetically unrelated participants. Results: Among 7,724 H/L individuals, HCM variant carriers were more likely to have a less than a high school education (p=0.02) and to report Spanish as their primary language compared to non-carriers (p=0.05). No significant differences were observed for household income, insurance status, employment status, years spent in the US, or nativity. Among 5,760 H/L individuals, HCM carriers had a significantly higher proportion of African ancestry compared to non-carriers (p<.0001). Conclusions: H/L with higher proportions of African ancestry appear to have a higher likelihood of being HCM genotype variant carriers. H/L individuals who were HCM carriers had lower education and were less acculturated, with regards to Spanish as their primary language compared to HCM non-carriers highlighting the importance of increasing access to care and awareness of HCM within at risk populations. Authors: Jorge Silva Enciso and Reniell Iñiguez are co-first authors.

Integrated analysis of local agricultural practices, community-led interventions, and climate change impacts on food insecurity in rural Azad Kashmir

Deep learning to quantify the pace of brain aging in relation to neurocognitive changes

Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since birth. Thus, it conveys poorly recent or contemporaneous aging trends, which can be better quantified by the (temporal) pace P of brain aging. Many approaches to map P , however, rely on quantifying DNA methylation in whole-blood cells, which the blood–brain barrier separates from neural brain cells. We introduce a three-dimensional convolutional neural network (3D-CNN) to estimate P noninvasively from longitudinal MRI. Our longitudinal model (LM) is trained on MRIs from 2,055 CN adults, validated in 1,304 CN adults, and further applied to an independent cohort of 104 CN adults and 140 patients with Alzheimer’s disease (AD). In its test set, the LM computes P with a mean absolute error (MAE) of 0.16 y (7% mean error). This significantly outperforms the most accurate cross-sectional model, whose MAE of 1.85 y has 83% error. By synergizing the LM with an interpretable CNN saliency approach, we map anatomic variations in regional brain aging rates that differ according to sex, decade of life, and neurocognitive status. LM estimates of P are significantly associated with changes in cognitive functioning across domains. This underscores the LM’s ability to estimate P in a way that captures the relationship between neuroanatomic and neurocognitive aging. This research complements existing strategies for AD risk assessment that estimate individuals’ rates of adverse cognitive change with age.

Abstract P3084: Yield of Various Recruitment Approaches for an Observational Cohort of Patients with Heart Failure with Preserved Ejection Fraction: A Single Center Experience from HeartShare

Introduction: The HeartShare Network aims to improve understanding of heart failure with preserved ejection fraction (HFpEF), a condition that disproportionately affects those with adverse social determinants of health. Ensuring diverse recruitment is key to advancing HFpEF research. This study examines response rates of various recruitment approaches across sociodemographic groups at a single HeartShare Clinical Center for an online registry including patients with and without HFpEF. Hypothesis: We hypothesized that electronic health record (EHR) messaging would be more effective in recruiting a diverse group of participants compared to telephone and in-person outreach. Methods: This observational study recruited patients aged 30 years and older between 8/1/2023-8/1/2024 from a tertiary-care academic center (Northwestern Medicine). Participants were contacted via phone calls, EHR portal messages, and in-person outreach. Data on age, race, and ethnicity were collected. Area Deprivation Index (ADI) was calculated using addresses. Statistical analyses, including Fisher’s Exact Test, were conducted using R to assess differences in recruitment rates across demographic groups and recruitment methods. Results: Among 8,080 patients contacted through EHR messaging, 144 (1.8%) enrolled in the online registry. In comparison, among 1,439 participants contacted via phone, 174 (12.1%) enrolled and among 193 approached in-person, 79 (41%) enrolled. Response rates (consenting after contact) varied for each approach by race and ethnicity (p<0.001). White participants had a response rate of 14% (after phone contact), 2% (after EHR contact), and 54% (after in-person contact). Black participants had a response rate of 6% (phone), <1% (EHR), and 49% (in-person). Hispanic participants had response rates of 5% (phone), <1% (EHR), and 38% (in-person). Among the enrolled, participants from the most deprived areas (ADI 5th quintile) were most effectively recruited through in-person methods compared with those from the least deprived quintile who were most successfully recruited via phone. Conclusion: While more individuals were contacted through EHR-based messaging, response rates were lower, especially among Black and Hispanic participants. In-person recruitment was the most successful in engaging minoritized populations or those residing in more deprived areas. Future studies should explore ways to improve response rates among diverse populations using EHR approaches.

Abstract P1087: Impact of Allostatic Load on Prevalent and Incident Pre-Heart Failure in the Echocardiographic Study of Latinos (ECHO-SOL)

Introduction: Allostatic load (AL) is multi-system index that physiologically quantifies the effects of chronic stress. The relationship of AL to pre-heart failure (HF), a precursor of clinical HF, has not been defined. Methods We studied 1,643 Hispanic/Latino adults who were free of clinical HF. An AL score was calculated using multiple physiologic parameters: (1) body mass index and waist hip ratio; (2) white blood cell count; (3) triglycerides, high-density lipoproteins, and low-density lipoproteins; (4) systolic blood pressure, pulse pressure and heart rate; and (5) serum glucose, insulin resistance, and glycosylated hemoglobin. For each parameter, points were assigned for values that fell outside normal ranges (Table 1). Echocardiographic measures of pre-HF were obtained across three domains: 1. systolic function (left ventricular ejection fraction [LVEF], global longitudinal strain [GLS]); 2. diastolic function (mitral inflow velocity [E], mitral annular early diastolic velocity [e’], E/e’); and 3. cardiac remodeling (left ventricular mass index [LVMI], relative wall thickness [RWT], and left atrial volume index [LAVI]). Measurements were obtained at baseline and at follow-up after an average of 4.3 years. Incident pre-HF was defined among those without pre-HF at baseline. Survey-weighted linear and logistic regression analyses were employed. Results The mean age of the study population was 56.4 years (SE = 0.395) and 58.5% were female. AL scores ranged from 0.5 - 10 with a mean of 5.15 (SE = 0.062). Greater AL burden was associated with worsened cardiac parameters (lower baseline LVEF, GLS, and e’; higher baseline LVMI, RWT, and E/e’), more prevalent systolic/diastolic dysfunction and structural remodeling, and increased odds of prevalent pre-HF after age and sex adjustment. Incident pre-HF risk also increased with a higher baseline AL burden (Table 2). Conclusion: Increasing AL was associated with prevalent cardiac abnormalities, prevalent pre-HF, and incident pre-HF. The use of AL as a predictive tool for pre-HF warrants further study.

Impact of interprovincial pairing assistance policies on sustainable agricultural development in Xinjiang of China

Abstract P3154: Out-Of-Hospital Pediatric Cardiac Arrest, Survival, And Associated Factors – A Systematic Review And Meta-Analysis

Introduction: Pediatric out-of-hospital cardiac arrest (OHCA) is associated with poor survival and neurological outcomes. Large variations in the incidence and survival have been reported across nations therefore, there is a need to systematically summarize the published data to report pooled survival and analyze the factors associated with survival. Methods: We conducted a comprehensive review of published literature using data from January 1, 2005, to June 30, 2023, including any observational or interventional study of OHCA in children that reported at least one survival outcome, confirmed to Utstein criteria for population selection and had a sample size of at least 50 patients. We separately looked at studies reporting all EMS (emergency medical service) assessed and treated OHCAs and those reporting only patients surviving to hospital admission following OHCA. We excluded studies focusing on specialized populations, duplicate data from the same registry, reporting combined data on in-hospital and out-of-hospital arrests or children and adults, and where data could not be separated. We used Der Simonian-Laird (DL) random-effects model to pool the results. Results: We included 34 studies with data from 69,834 pediatric OHCAs assimilating more than 20 years of global data. Pooled survival and neurological outcome for EMS-assessed and treated OHCAs were 13% (95% CI: 11% to 15%) and 6% (95% CI: 5% to 8%) respectively. For the admitted patients, survival rates were 46% (95% CI: 40% to 53%) and 28% (95% CI: 19% to 37%) respectively. Survival was highest for Europe, followed by North America, Asia and Australia. Predictors of improved survival included witnessed arrest, shockable rhythm, public location of arrest, bystander CPR, and age > 1 year. Having a cardiac cause of arrest was associated with worse survival. High heterogeneity was observed for pooled survival and most of the predictors. The I 2 was reduced to 0% when reporting region-specific results. Conclusions: Survival for pediatric OHCA patients has improved over the years but remains low. Geographical disparities exist owing to differences in pre-hospital care organization. The standardized Utstein criteria need to be widely implemented to improve the comparison of global estimates.

Abstract P2024: The Association of Cannabis Use with Risk of Mortality, Incident Stroke, and Incident Myocardial Infarction in a Minnesota Healthcare System, 2016-2023

Introduction: Daily cannabis use is now more common than daily alcohol use, but we lack a comprehensive understanding of the association of cannabis use with cardiovascular disease (CVD). We conducted a longitudinal analysis to assess the role of cannabis use associated with mortality, incident stroke, and incident myocardial infarction (MI). Methods: We included adult patients who received regular care (at least 2 outpatient visits in a 3-year span) from a large Minnesota healthcare system from 2016-2023. The baseline date was defined as the 2 nd qualifying visit, and variables were captured using ICD codes from medical records. Cannabis users were matched with up to four non-cannabis users by age, sex, race-ethnicity, baseline date, and days between the 1 st and 2 nd visit. Outcomes included incident stroke and MI obtained from inpatient admissions and mortality, which was obtained through linkage to state records. We used Cox proportional hazards models to assess the association between cannabis use and each outcome, adjusting for prevalent demographics and comorbidities at the time of the baseline date. Results: We matched 30,529 cannabis users to 121,623 non-cannabis users, with a mean (SD) age of 36 (15) years, 56% were male, and 71% were White race/ethnicity. During a mean (SD) follow-up of 3.9 (2.4) years, there were 5,425 deaths, 719 incident strokes, and 580 incident MIs (Table). After adjusting for potential confounders and mediators, the use of cannabis was associated with a higher risk of mortality [HR (95%CI): 1.41 (1.32, 1.53)], stroke [HR (95%CI): 1.25 (1.03, 1.53)] and MI [HR (95%CI): 1.53 (1.23, 1.88)] compared to non-users. Conclusion: Cannabis use was associated with an increased risk of mortality and CVD, even after fully adjusting for potential confounders and other substance use in this general healthcare system population. Given the increasing cannabis use in the US, more research is needed to understand the role of cannabis in CVD pathways and how increasing use alters CVD epidemiology.

Sample observed effects: enumeration, randomization and generalization

Abstract We study generalization of intervention effects across several simulated and real-world samples. We start by formulating the concept of the ‘background’ of a sample effect observation. We then formulate conditions for effect generalization based on a sample’s set of (observed and unobserved) backgrounds. This reveals two limits for effect generalization: (1) when effects of a variable are observed under all their enumerable backgrounds, or, (2) when backgrounds have become sufficiently randomized. We use the resulting combinatorial framework to re-examine open issues in current causal effect estimators: out-of-sample validity, concurrent estimation of multiple effects, bias-variance tradeoffs, statistical power, and connections to current predictive and explaining techniques. Methodologically, these definitions also allow us to replace the parametric estimation problems that followed the ‘counterfactual’ definition of causal effects by combinatorial enumeration and randomization problems in non-experimental samples. We use the resulting non-parametric framework to demonstrate (External Validity, Unconfoundness and Precision) tradeoffs in the performance of popular supervised, explaining, and causal-effect estimators.

Abstract P3152: Cost-Effectiveness of Dietary Salt Reduction and Universal Screening Programs to Control Hypertension in US Young Adults

Introduction: Almost half of US young adults (aged 18-39 years) have hypertension. This is due to a high prevalence of risk factors, including the fact that most young adults exceed recommended daily sodium intake, alongside underdiagnosis and undertreatment. Cumulative exposure to elevated blood pressure (BP) in young adulthood increases later life risk of cardiovascular disease (CVD), so interventions that reduce BP levels in this age-group could improve population health. Objective: We aimed to estimate the cost and health-related quality of life benefits of two interventions at different points in the pathway of hypertension control in young adults: reducing dietary salt intake (to reduce HTN incidence) and increasing BP screening rates (to increase diagnosis and treatment). Methods: The CVD Policy Model, an established computer simulation model, estimated lifetime costs and quality-adjusted life years (QALYs) associated with BP-reducing interventions in a cohort of 100,000 US young adults. Risk of CVD events in the model was determined by a range of CVD risk factors, including cumulative exposure to systolic BP throughout the lifecourse. We modelled two hypothetical interventions: a population-level policy that reduces average sodium consumption by 1 g/day and an annual hypertension screening program for all young adults. We estimated the maximum price at which each intervention would be cost-effective (incremental cost-effectiveness ratio [ICER] less than $100,000/QALY) compared to usual care. Results: In a cohort of 100,000 US young adults, reducing dietary salt consumption by 1 g/day would produce around 19,300 QALYs and prevent around 1,400 CVD events over a lifetime horizon. For policymakers, it would be cost-effective to invest up to $55 million ($550 per young adult) to achieve this reduction in salt intake. Universal screening would also improve health outcomes (575 QALYs gained, 190 CVD events prevented), but the maximum cost-effective price for this policy was much lower ($17 per young adult). Conclusion: Reducing incidence and improving treatment of hypertension in young adulthood could improve population health substantially.

Abstract P2047: Provider understanding of coronary artery calcium testing in ASCVD risk stratification and associated racial disparities

Background: Coronary Artery Calcium (CAC) scoring is critical in assessing Atherosclerotic Cardiovascular Disease (ASCVD) risk. However, many primary care physicians lack confidence and familiarity with its application. Significant racial disparities in CAC scoring utilization may affect patient outcomes. Objective/Hypothesis: We hypothesized that a brief educational intervention would enhance physicians' confidence, knowledge, and utilization of CAC scoring and awareness of racial disparities. Methods: A pre- and post-intervention study (Image 1) was conducted among 39 physicians at the University of Louisville. The intervention included a 20-minute educational session on CAC scoring and racial disparities, along with a video summarizing the ACC2018 guidelines. A summary of key points for clinical practice and ASCVD plus calculator app was provided. Data were collected using a structured questionnaire before and after the intervention. Viewing time and engagement were recorded. Descriptive and inferential statistics analyzed the data. Results: The average correct physician responses increased from a mean of 59.5% pre-intervention to 92.0% post- intervention. Post-intervention, the number of physicians who felt confident or very confident in CAC testing increased from 17.9% to 94.8%. Thirty-three out of 39 physicians (84.6%) reported likely to use CAC testing more frequently. Correct responses on racial disparities improved from 59% pre-intervention to 92.0% post-intervention. (Image 2). The average viewing time was 28 minutes. Time spent on the questionnaires was 14 min pre and 12 min post. Conclusion: Our targeted educational intervention significantly enhanced physicians' knowledge and confidence in CAC scoring for ASCVD risk assessment and raised awareness about racial disparities, promoting more equitable practices.

Enhanced diplopia detection and binocular single vision assessment through virtual reality: A comprehensive study

Urine electrooxidation for energy–saving hydrogen generation

Abstract P3161: Discrimination in Healthcare is Associated with Increased Stroke Risk among Older Adults in the United States

Introduction: Discrimination in healthcare strains patient-provider relationships and may contribute to disparities in outcomes. When patients feel disrespected, they could be less likely to trust providers or seek follow-up care, which poses a challenge for cardiovascular risk management. We assessed the association between discrimination in healthcare and incidence of stroke. Methods: We used nationally-representative longitudinal data from the 2008-2020 Health and Retirement Study to examine the association between stroke and discrimination in healthcare. Participants were ages 50-80 at baseline, had no history of stroke, and were followed for up to 12 years (mean follow-up=6.9 years). First occurrence of stroke was ascertained from participant-reported diagnosis of stroke by a doctor during follow-up (month/year). Discrimination in healthcare was assessed at baseline by asking respondents how often they “receive poorer service or treatment than other people from doctors or hospitals.” Cox proportional hazards models were used to estimate the incidence of stroke during the follow-up period (n=518 events). Confounding was controlled through adjustment for baseline covariates that included sociodemographic factors (age, gender, race, ethnicity, education), health status (disease diagnoses [diabetes, hypertension, heart disease]), and prior healthcare utilization (doctor visits and hospitalizations in past 2 years). Results: Among study participants (n=14,215, median age 62, 41.01% male, 72.68% White, 19.63% Black, 7.69% Hispanic), 19.19% (n=2,728) reported experiencing discrimination in healthcare settings. Those who experienced discrimination were more likely to have a stroke during follow-up compared to participants who did not report discrimination (4.5% vs. 3.4%, P =.010). Unadjusted proportional hazard models showed that discrimination in healthcare was associated with an increased hazard of stroke (hazard ratio [HR]=1.33, 95% confidence interval [CI]= 1.08-1.62). The association persisted after adjusting for all covariates (HR= 1.29, CI=1.05-1.58). Conclusions: Discrimination in healthcare was associated with increased stroke risk after adjusting for factors which impact both exposure to discrimination and risk of stroke. Future research should consider how changes in health status and/or experiences of discrimination during the course of care may contribute to this association.

Abstract P2121: Associations of Physical Activity and Sedentary Behavior with CVD Risk: Mediation by Cardiac Autonomic Function (Pooled Analysis of Six NHLBI Cohorts)

Objective: High sedentary behavior (SB) and low physical activity (PA) can worsen glycemic control, impairing cardiac autonomic function (CAF) and increasing cardiovascular disease (CVD) risk. We examined 1) associations of PA and SB with CVD risk and 2) whether CAF, assessed by heart rate variability (HRV), mediated these associations overall and in those with and without type 2 diabetes (T2D). Methods: We analyzed data from 28,897 participants from six NHLBI cohorts: Atherosclerosis Risk in Communities Study, Coronary Artery Risk Development in Young Adults Study, Cardiovascular Health Study, Framingham Heart Study, Jackson Heart Study, and the Multi-Ethnic Study of Atherosclerosis. We harmonized self-reported PA and SB data as the cumulative average of PA and SB percentiles over all timepoints prior to a fatal/non-fatal CVD event or end of follow-up. HRV was expressed as the SD of normal-to-normal RR intervals (SDNN)—a time-domain measure of HRV and our proxy for CAF. Covariates included harmonized data on age, race/ethnicity, sex, study center, education, smoking, alcohol, diet, and lipid, blood pressure, and T2D medications. We used Cox regression to examine associations of PA and SB with CVD risk, reporting standardized betas for PA and SB. Estimate pooling was performed with a random effects model. HRV mediation was the % difference in pooled PA and SB betas when HRV was in vs. out of the model, with ≥10% beta attenuation defined as mediation. Results: Across cohorts, mean age was 30-71 years, with 8,780 CVD events observed and a mean follow-up of 7,090 days until a CVD event. PA was strongly inversely associated with CVD risk, while SB had a marginal positive association with CVD risk. There was no evidence of CAF mediation for PA. For SB, we observed no evidence of CAF mediation overall but, for those with and without T2D, we observed 16.1% and 7.7% mediation, respectively (Table). Conclusion: Additional research is needed with more robust HRV and SB measures to discern whether the relationship between SB and CVD risk is truly mediated by CAF and whether this mediation varies by T2D status.

An investigation of the mechanical properties and adsorption potentials of Fe2O3@SiO2-L-cysteine-cellulose system

In-situ adsorption-coupled-oxidation enabled mercury vapor capture over sp-hybridized graphdiyne

Abstract Developing efficient and sustainable carbon sorbent for mercury vapor (Hg0) capture is significant to public health and ecosystem protection. Here we show a carbon material, namely graphdiyne with accessible sp-hybridized carbons (HsGDY), that can serve as an effective “trap” to anchor Hg atoms by strong electron-metal-support interaction, leading to the in-situ adsorption-coupled-oxidation of Hg. The adsorption process is benefited from the large hexagonal pore structure of HsGDY. The oxidation process is driven by the surface charge heterogeneity of HsGDY which can itself induce the adsorbed Hg atoms to lose electrons and present a partially oxidized state. Its good adaptability and excellent regeneration performance greatly broaden the applicability of HsGDY in diverse scenarios such as flue gas treatment and mercury-related personal protection. Our work demonstrates a sp-hybridized carbon material for mercury vapor capture which could contribute to sustainability of mercury pollution industries and provide guide for functional carbon material design.