Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution

Rongyu Zhang; Jingqi Qi; Michaela McKasson; Jongchan Choi; Vanessa Gutierrez; Conor Brennan; Sunga Hong; William Chour; Rachel H. Ng; Jingyi Xie; Dan Yuan; Andrew Webster; Simranjeet K. Sidhu; Abby Anderson; Daniel Chen; Rick Edmark; Kim M. Murray; Sarah Li; Connor McDonald; Lee Rowen; Shuo Wang; Yusuf Rasheed; Yapeng Su; Jamie R. Wagner; Jia Ming Chen; Karla Nawaly; Jie Fu; Alexandria Duven; Stephen J. Forman; Mihae Song; Saul J. Priceman; Christine E. Brown; Antoni Ribas; Deborah J. Wong; Kelly G. Paulson; Charles W. Drescher; Cristina Puig-Saus; Jason D. Goldman; Cornelia L. Trimble; James R. Heath

doi:10.1038/s41467-026-72396-7

Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution

R Rongyu Zhang J Jingqi Qi (F.M. Kirby Neurobiology Center, Boston Children’s Hospital) M Michaela McKasson J Jongchan Choi V Vanessa Gutierrez C Conor Brennan S Sunga Hong W William Chour R Rachel H. Ng J Jingyi Xie D Dan Yuan A Andrew Webster S Simranjeet K. Sidhu A Abby Anderson D Daniel Chen R Rick Edmark K Kim M. Murray S Sarah Li C Connor McDonald L Lee Rowen S Shuo Wang Y Yusuf Rasheed Y Yapeng Su J Jamie R. Wagner J Jia Ming Chen K Karla Nawaly J Jie Fu (Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory of Advanced Negative Carbon Technologies, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu 215123, China) A Alexandria Duven S Stephen J. Forman (City of Hope National Medical Center, Duarte, CA) M Mihae Song S Saul J. Priceman C Christine E. Brown A Antoni Ribas D Deborah J. Wong K Kelly G. Paulson C Charles W. Drescher C Cristina Puig-Saus J Jason D. Goldman C Cornelia L. Trimble J James R. Heath

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published May 12, 2026

DOI 10.1038/s41467-026-72396-7

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (40)

R

Rongyu Zhang

J

Jingqi Qi

F.M. Kirby Neurobiology Center, Boston Children’s Hospital

M

Michaela McKasson

J

Jongchan Choi

V

Vanessa Gutierrez

C

Conor Brennan

S

Sunga Hong

W

William Chour

R

Rachel H. Ng

J

Jingyi Xie

D

Dan Yuan

A

Andrew Webster

S

Simranjeet K. Sidhu

A

Abby Anderson

D

Daniel Chen

R

Rick Edmark

K

Kim M. Murray

S

Sarah Li

C

Connor McDonald

L

Lee Rowen

S

Shuo Wang

Y

Yusuf Rasheed

Y

Yapeng Su

J

Jamie R. Wagner

J

Jia Ming Chen

K

Karla Nawaly

J

Jie Fu

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory of Advanced Negative Carbon Technologies, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu 215123, China

A

Alexandria Duven

S

Stephen J. Forman

City of Hope National Medical Center, Duarte, CA

M

Mihae Song

S

Saul J. Priceman

C

Christine E. Brown

A

Antoni Ribas

D

Deborah J. Wong

K

Kelly G. Paulson

C

Charles W. Drescher

C

Cristina Puig-Saus

J

Jason D. Goldman

C

Cornelia L. Trimble

J

James R. Heath

Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution

Article Details

Journal Info

Authors (40)

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