Weight-independent effects of dietary carbohydrate-to-fat ratio on metabolomic profiles: secondary outcomes of a 5-month randomized controlled feeding trial

Angeliki M. Angelidi; Eric Bartell; Yisong Huang; Oana A. Zeleznik; Núria Estanyol-Torres; Michael Y. Mi; Shilpa N. Bhupathiraju; Rachel S. Kelly; Clemens Wittenbecher; Jessica Lasky-Su; Clary B. Clish; David S. Ludwig; Cara B. Ebbeling; Joel N. Hirschhorn

doi:10.1038/s41467-026-68353-z

Weight-independent effects of dietary carbohydrate-to-fat ratio on metabolomic profiles: secondary outcomes of a 5-month randomized controlled feeding trial

A Angeliki M. Angelidi E Eric Bartell Y Yisong Huang O Oana A. Zeleznik N Núria Estanyol-Torres M Michael Y. Mi S Shilpa N. Bhupathiraju R Rachel S. Kelly C Clemens Wittenbecher J Jessica Lasky-Su (Harvard Medical School) C Clary B. Clish (Broad Institute of Massachusetts Institute of Technology and Harvard) D David S. Ludwig C Cara B. Ebbeling J Joel N. Hirschhorn

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 17, 2026

DOI 10.1038/s41467-026-68353-z

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (14)

A

Angeliki M. Angelidi

E

Eric Bartell

Y

Yisong Huang

O

Oana A. Zeleznik

N

Núria Estanyol-Torres

M

Michael Y. Mi

S

Shilpa N. Bhupathiraju

R

Rachel S. Kelly

C

Clemens Wittenbecher

J

Jessica Lasky-Su

Harvard Medical School

C

Clary B. Clish

Broad Institute of Massachusetts Institute of Technology and Harvard

D

David S. Ludwig

C

Cara B. Ebbeling

J

Joel N. Hirschhorn

Weight-independent effects of dietary carbohydrate-to-fat ratio on metabolomic profiles: secondary outcomes of a 5-month randomized controlled feeding trial

Article Details

Journal Info

Authors (14)

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