Visible Light‐Driven Deracemization of Cyclic Sulfonamides by Quinuclidine and Chiral Arylthiol Catalysis
Abstract
Abstract A photocatalytic system comprising an achiral tertiary amine and a chiral C 2 ‐symmetric arylthiol was developed for the deracemization of various cyclic sulfonamides. This protocol exhibited high yields, good to excellent enantioselectivity, and broad substrate scope. The resulting products can be readily transformed into diverse diarylmethylamines, presenting a viable alternative to metal‐catalyzed asymmetric methods. The reaction pathway involving a relay of non‐enantioselective hydrogen‐atom abstraction (HAA) and enantioselective hydrogen‐atom delivery (HAD).
Article Details
Authors (5)
Lei Dai
Chaoren Shen
State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering
Jing Wang
Hunan Cancer Hospital Changsha China
Yanzhong Li
Kaiwu Dong
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, State Key Laboratory of Petroleum Molecular & Process Engineering, School of Chemistry and Molecular Engineering