Vinigrol Tricyclic Scaffold Biosynthesis Employs an Atypical Terpene Cyclase and a Multipotent Cyclization Cascade

K Kento Tsukada (Graduate School of Pharmaceutical Sciences) F Fumito Sato (Graduate School of Pharmaceutical Sciences) T Taro Matsuyama (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan) R Ryo Matsuda (Graduate School of Pharmaceutical Sciences) T Taro Ozaki (Graduate School of Pharmaceutical Sciences) Y Yohei Morishita (Graduate School of Pharmaceutical Sciences) S Sho Furumura (Graduate School of Pharmaceutical Sciences) Y Yuto Homma (Graduate School of Pharmaceutical Sciences) H Hikaru Sekiya (Graduate School of Pharmaceutical Sciences) A Akihiro Sugawara (Graduate School of Pharmaceutical Sciences) M Masataka Kubota (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan) T Takaaki Mitsuhashi (Division of Advanced Molecular Science) Y Yoko Yasuno (Graduate School of Science, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi, Osaka 558-8585, Japan) T Tetsuro Shinada (Graduate School of Science, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi, Osaka 558-8585, Japan) R Ryuhei Nagata (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan) T Tomohisa Kuzuyama T Tohru Taniguchi (Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University, North 21 West 11, Sapporo 001-0021, Japan) M Makoto Fujita (Tokyo College, UT Institutes for Advanced Study, The University of Tokyo, Mitsui Link Lab Kashiwanoha 1, FS CREATION, 6-6-2 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan) M Masanobu Uchiyama (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) T Teigo Asai (Graduate School of Pharmaceutical Sciences)

Article Details

Volume / Issue Vol. 147, Issue 49
Published December 10, 2025
Pages 45168-45177
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (20)

K

Kento Tsukada

Graduate School of Pharmaceutical Sciences

F

Fumito Sato

Graduate School of Pharmaceutical Sciences

T

Taro Matsuyama

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan

R

Ryo Matsuda

Graduate School of Pharmaceutical Sciences

T

Taro Ozaki

Graduate School of Pharmaceutical Sciences

Y

Yohei Morishita

Graduate School of Pharmaceutical Sciences

S

Sho Furumura

Graduate School of Pharmaceutical Sciences

Y

Yuto Homma

Graduate School of Pharmaceutical Sciences

H

Hikaru Sekiya

Graduate School of Pharmaceutical Sciences

A

Akihiro Sugawara

Graduate School of Pharmaceutical Sciences

M

Masataka Kubota

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan

T

Takaaki Mitsuhashi

Division of Advanced Molecular Science

Y

Yoko Yasuno

Graduate School of Science, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi, Osaka 558-8585, Japan

T

Tetsuro Shinada

Graduate School of Science, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi, Osaka 558-8585, Japan

R

Ryuhei Nagata

Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

T

Tomohisa Kuzuyama

T

Tohru Taniguchi

Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University, North 21 West 11, Sapporo 001-0021, Japan

M

Makoto Fujita

Tokyo College, UT Institutes for Advanced Study, The University of Tokyo, Mitsui Link Lab Kashiwanoha 1, FS CREATION, 6-6-2 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan

M

Masanobu Uchiyama

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

T

Teigo Asai

Graduate School of Pharmaceutical Sciences