Universal Metal‐Exchange Strategy for Room Temperature Synthesis of Single‐Atom Nanozymes

J Jie Zhang Z Zezhong Huang (Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P.R. China) B Bolong Xu (Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P.R. China) Q Qingyuan Wu (New Cornerstone Science Laboratory, State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, and National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials, College of Chemistry and Chemical Engineering) Z Zhijun Huang H Huiyu Liu (School of Physical Science and Technology)

Abstract

Abstract The high‐temperature limitations of single‐atom catalysts (SACs) synthesis, primarily thermal aggregation and low metal loadings, are overcome by a novel room‐temperature metal‐exchange strategy. We leverage the weak Zn─N coordination in high‐loading Zn SACs (12.10 wt%, synthesized via controlled ZIF‐8 pyrolysis) as a platform for the facile exchange with a broad range of metals (Mn, Fe, Co, Ni, Cu, Ru, Pt, up to 12.67 wt%) and the creation of multi‐metallic species. This ambient‐temperature approach significantly reduces aggregation, enhancing the exposure of catalytic active sites and delivering superior multi‐enzyme‐like activities (catalase, peroxidase, oxidase). Our work not only provides a scalable, low‐temperature route to high‐performance SACs but also reveals crucial insights into the stability of SACs under metal‐ion conditions.

Article Details

Volume / Issue Vol. 64, Issue 31
Published July 28, 2025
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (6)

J

Jie Zhang

Z

Zezhong Huang

Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P.R. China

B

Bolong Xu

Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing 100029 P.R. China

Q

Qingyuan Wu

New Cornerstone Science Laboratory, State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, and National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials, College of Chemistry and Chemical Engineering

Z

Zhijun Huang

H

Huiyu Liu

School of Physical Science and Technology