Unintegrated HIV-1 DNA recruits cGAS via its histone-binding domain to escape innate immunity
Abstract
To ensure optimal replication and spread, viruses have evolved countermeasures to evade type 1 IFN-mediated antiviral activity. During the early viral replication cycle steps until uncoating, the HIV-1 core protects viral pathogen associated molecular patterns (viral RNA and reverse transcription products) from recognition by innate immune sensors, including cGAS. However, after capsid uncoating, unintegrated viral DNA (uvDNA) becomes accessible. Here, we show that HIV-1 uses chromatin-mediated cGAS inactivation as a mechanism to protect its uvDNA from innate immune activation.
Article Details
Journal Info
Proceedings of the National Academy of Sciences
National Academy of Sciences
Authors (6)
Cyprien Jahan
Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS Université de Montpellier-UMR9002
Lucie Bonnet-Madin
Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS Université de Montpellier-UMR9002
Shinichi Machida
Department of Structural Virology, National Institute of Global Health and Medicine, Japan Institute for Health Security
Bijan Sobhian
Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS Université de Montpellier-UMR9002
Suzie Thenin-Houssier
Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS Université de Montpellier-UMR9002
Monsef Benkirane
Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS Université de Montpellier-UMR9002