Tyrosine kinase inhibitors were well-tolerated among patients with different etiologies of advanced HCC with lower survival in non-viral patients
Abstract
Abstract We studied the characteristics and survival of patients with sorafenib-treated HCC and impact of underlying etiology on outcomes. This retrospective multicenter study recruited patients with sorafenib-treated advanced HCC (12/2016 to 4/2023) till death or the study end (2/2024). Time to progression (TTP) and overall survival (OS) were recorded. We evaluated; Clinico-laboratory and imaging predictors of OS, The impact of underlying etiology on tumor variables, outcomes and tolerance for sorafenib > 6 months. This study included 706 patients. Median duration of Sorafenib therapy was 240.00 (90.00–360.00) days. Median OS was 314.00(146.00–601.00) days. Median TTP was 180.00(90.00–330.00) days. COX regression revealed that the independent factors of mortality were baseline AST, Tumor size, hepatic vein thrombosis (HVT), development of jaundice and shifting to Regorafenib. Advanced HCCs were more common on top of non-cirrhotic non-viral and HBV-related liver disease. Adverse events, TTP and tumor response didn’t differ with the underlying etiology. Median OS was lower in non-viral-related HCC than HCV-related HCC (218.00 versus 326.50 days, P-value = 0.048). Patients who continued sorafenib > 6 months had lower AFP, HVT, adverse effects and better tumor response after 3 months. OS is lower in non-viral Sorafenib-treated HCC compared with viral-related HCC and Sorafenib was well-tolerated among different HCC etiologies.
Article Details
Authors (41)
Eman M. F. Barakat
Mohamed Kohla
Hossam Dabees
Hend Ibrahim Shousha
Ehab F. Moustafa
Mohamed El-Kassas
Mona Shoukry Aziz
Eman Elkhateeb
Ashraf Omar Abdelaziz
Mohamed Omar Abdelmalek
Aly Azmy
Ahmed Tawheed
Walaa Mosaad Aboganob
Hossam Taha
Rania Lithy
Ahmed Radwan
Dalia Ghoraba
Hamdy Sayed
Anwar Nassief
Mostafa Elhelbawy
Mohamed Mahmoud nabeel
Mohamed A. Medhat
Safaa Ragab Askar
Eman Marwan
Eman Rewisha
Tamer Elbaz
Sayed Hassan Ahmed
Nevien Fouad elfouly
Nermeen Abdeen
Ahmed Hosni Abdelmaksoud
Asmaa A. Abdeltawab
Mostafa Abd Alfattah Shamkh
Ahmed Ramadan
Yasser Arafat Abdelrazek
Mohamed Bassam
Sayed Ahmed Sayed
Rasha Salah Hussein
Ammar Alrajhi
Allam Elsayed Allam
Omnia A. Seyam
Mohamed Said