Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas

Anaïs Aussel; Ivan Nemazanyy; Ashaina Vandenberghe; Pauline Meola; Noémie Dorat; Rachel Paul; Lama Habbouche; Laurie Exposito; Nicolas Nottet; Virginie Petrilli; Edmond Chiche; Nicolas Mounier; Sandrine Marchetti; Cédric Chaveroux; Jean-Ehrland Ricci; Johanna Chiche

doi:10.1038/s41467-026-70066-2

Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas

A Anaïs Aussel I Ivan Nemazanyy A Ashaina Vandenberghe P Pauline Meola N Noémie Dorat R Rachel Paul (Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal) L Lama Habbouche L Laurie Exposito N Nicolas Nottet V Virginie Petrilli (Centre de Recherche en Cancérologie de Lyon) E Edmond Chiche N Nicolas Mounier S Sandrine Marchetti C Cédric Chaveroux J Jean-Ehrland Ricci J Johanna Chiche

Download PDF View Original

APA MLA Chicago BibTeX RIS

Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published February 27, 2026

DOI 10.1038/s41467-026-70066-2

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (16)

A

Anaïs Aussel

I

Ivan Nemazanyy

A

Ashaina Vandenberghe

P

Pauline Meola

N

Noémie Dorat

R

Rachel Paul

Genetics and Development Research Unit, Institut de Recherches Cliniques de Montréal

L

Lama Habbouche

L

Laurie Exposito

N

Nicolas Nottet

V

Virginie Petrilli

Centre de Recherche en Cancérologie de Lyon

E

Edmond Chiche

N

Nicolas Mounier

S

Sandrine Marchetti

C

Cédric Chaveroux

J

Jean-Ehrland Ricci

J

Johanna Chiche

Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas

Article Details

Journal Info

Authors (16)

Related Articles from this Journal

Synthesis of adaptive 15N-nitrosyl-Co7 nanocluster for electrocatalytic C–H functionalization

Pan-Ebolavirus nanoparticle vaccine provides protection in rodents from lethal infection by Zaire and Sudan viruses

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk

Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants

Allele-specific chromatin architecture shapes imprinted domains and coordinates a distal enhancer and antisense transcription at the mouse Mest-Copg2 domain