Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor response

Ming Yi; Tianye Li; Yinhui Gu; Mengke Niu; Dixuan Xue; Shengtao Hu; Yuze Wu; Bin Zhao; Di Zhang; Yingkang Ma; Minjun Zhang; Jing Zhang; Yongxiang Yan; Pengfei Zhou; Xiaojun Zhang; Zhuxian Zhou; Qian Chu; Kongming Wu; Zhijun Dai

doi:10.1038/s41467-026-69456-3

Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor response

M Ming Yi T Tianye Li Y Yinhui Gu M Mengke Niu D Dixuan Xue S Shengtao Hu Y Yuze Wu B Bin Zhao D Di Zhang Y Yingkang Ma M Minjun Zhang J Jing Zhang Y Yongxiang Yan P Pengfei Zhou (College of Pharmacy) X Xiaojun Zhang (Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science) Z Zhuxian Zhou Q Qian Chu (Department of Oncology Tongji Hospital Huazhong University of Science and Technology Wuhan China) K Kongming Wu Z Zhijun Dai

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published February 09, 2026

DOI 10.1038/s41467-026-69456-3

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (19)

M

Ming Yi

T

Tianye Li

Y

Yinhui Gu

M

Mengke Niu

D

Dixuan Xue

S

Shengtao Hu

Y

Yuze Wu

B

Bin Zhao

D

Di Zhang

Y

Yingkang Ma

M

Minjun Zhang

J

Jing Zhang

Y

Yongxiang Yan

P

Pengfei Zhou

College of Pharmacy

X

Xiaojun Zhang

Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science

Z

Zhuxian Zhou

Q

Qian Chu

Department of Oncology Tongji Hospital Huazhong University of Science and Technology Wuhan China

K

Kongming Wu

Z

Zhijun Dai

Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor response

Article Details

Journal Info

Authors (19)

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