Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis

D David B. Meya F Fiona V. Cresswell (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) B Biyue Dai N Nicole Engen K Kogieleum Naidoo A Ahmad Rizal Ganiem (Department of Neurology, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin Hospital, Bandung, Indonesia) D Darma Imran (Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia) M Mable Kabahubya (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) R Richard J. Lessells (Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, University of KwaZulu–Natal, Durban) V Vycke Yunivita (Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia) R Riwanti Estiasari (Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia) L Lillian Tugume (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) B Bongeka Hlabisa (Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, University of KwaZulu–Natal, Durban) M Media Yuni Kurniawati (Department of Neurology, Cibabat General Hospital, Cimahi, Indonesia) N Noveline Sagita (Department of Neurology, Immanuel Hospital, Bandung, Indonesia) E Enock Kagimu (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) K Kartika Maharani (Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia) J Jane Gakuru (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) M Maula N. Gaharu (Department of Neurology, Bhayangkara TK. I Pusdokkes Polri Hospital, Jakarta, Indonesia) T Timothy Mugabi (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) S Sarah Kimuda (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) S Suzan Namombwe (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) L Lindsey te Brake (Department of Pharmacy, Pharmacology and Toxicology, Radboud Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands) R Rob Aarnoutse (Department of Pharmacy, Pharmacology and Toxicology, Radboud Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands) E Elin M. Svensson (Department of Pharmacy, Pharmacology and Toxicology, Radboud Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands) A Ananta S. Bangdiwala (Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis) S Sylvia Namanda (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) N Nathan C Bahr (Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis) A Abdu K. Musubire (Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda) M Mahomed Yunus Suleman Moosa (Department of Infectious Diseases, Division of Internal Medicine, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa) R Raph L. Hamers (Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.) S Suzaan Marais (Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa) D David R. Boulware R Reinout van Crevel (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom) R Rovina Ruslami (Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia)

Article Details

Volume / Issue Vol. 393, Issue 24
Published December 18, 2025
Pages 2434-2446
ISSN 0028-4793
Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (35)

D

David B. Meya

F

Fiona V. Cresswell

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

B

Biyue Dai

N

Nicole Engen

K

Kogieleum Naidoo

A

Ahmad Rizal Ganiem

Department of Neurology, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin Hospital, Bandung, Indonesia

D

Darma Imran

Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

M

Mable Kabahubya

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

R

Richard J. Lessells

Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, University of KwaZulu–Natal, Durban

V

Vycke Yunivita

Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia

R

Riwanti Estiasari

Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

L

Lillian Tugume

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

B

Bongeka Hlabisa

Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, University of KwaZulu–Natal, Durban

M

Media Yuni Kurniawati

Department of Neurology, Cibabat General Hospital, Cimahi, Indonesia

N

Noveline Sagita

Department of Neurology, Immanuel Hospital, Bandung, Indonesia

E

Enock Kagimu

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

K

Kartika Maharani

Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

J

Jane Gakuru

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

M

Maula N. Gaharu

Department of Neurology, Bhayangkara TK. I Pusdokkes Polri Hospital, Jakarta, Indonesia

T

Timothy Mugabi

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

S

Sarah Kimuda

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

S

Suzan Namombwe

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

L

Lindsey te Brake

Department of Pharmacy, Pharmacology and Toxicology, Radboud Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands

R

Rob Aarnoutse

Department of Pharmacy, Pharmacology and Toxicology, Radboud Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands

E

Elin M. Svensson

Department of Pharmacy, Pharmacology and Toxicology, Radboud Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands

A

Ananta S. Bangdiwala

Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis

S

Sylvia Namanda

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

N

Nathan C Bahr

Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis

A

Abdu K. Musubire

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

M

Mahomed Yunus Suleman Moosa

Department of Infectious Diseases, Division of Internal Medicine, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

R

Raph L. Hamers

Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

S

Suzaan Marais

Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa

D

David R. Boulware

R

Reinout van Crevel

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

R

Rovina Ruslami

Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia