Trends and patterns of antimicrobial resistance among Staphylococcus aureus isolated from various clinical specimens: a national laboratory-based AMR surveillance, 2020–2024
Abstract
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is a global public health concern responsible for a wide range of infections. In Ethiopia, patterns and trends of MRSA in various clinical specimens are limited. Therefore, this study aimed to determine the trend and pattern of S. aureus isolated from 16 AMR surveillance sentinel sites. Laboratory-based AMR surveillance data from 2020 to 2024 was collected from various clinical specimens. Culture and antimicrobial susceptibility testing were performed using standard microbiology techniques. The data were analyzed using WHONET 2025 software version 25.15.5 and SPSS version 22. A total of 4,243 S. aureus isolates were analyzed in 16 AMR sentinel sites; most of them were from health facilities in Addis Ababa (46.6%). The trend of penicillin resistance among tested isolates showed persistently high (~ 90%) between 2020 and 2024. The trend of MRSA showed a noticeable slight decline from 37% in 2021 and 2022 to 30% in the 2024 period, and its overall prevalence was 32.2% (95% CI 30.3, 34.2). There has been a slight declining trend of MRSA since 2022 and fluctuating resistance rates in routinely tested antimicrobials. The susceptibility of isolates to last-resort antibiotics remains promising for treatment. The significant presence of MRSA in participating hospitals warrants continuous surveillance and strengthens the implementation of infection prevention and control measures.
Article Details
Authors (40)
Zeleke Ayenew
Meseret Aseffa Oda
Semira Ebrahim Geleto
Tewodros Minwuyelet Anteneh
Etsehiwot Adamu Tsegaye
Yonas Mekonnen Gebeyehu
Dejenie Shiferaw Teklu
Degefu Beyene Gobena
Amete Mihret Teshale
Gebrie Alebachew Belete
Surafel Fentaw Dinku
Tesfa Addis Kefale
Elias Seyoum Derebe
Abera Abdeta Kitaba
Dawit Assefa Wendifraw
Ebisa Fekede
Bruke Gezhagene Birhanu
Mheret Tesfaye Gobena
Addis Abebe
Degefe Habte
Senahara Korsa Wake
Dawit Sekata Duressa
Jemal Mohammed Hussien
Gemechis Bulti Tura
Eshetu Gadisa
Dereje Mamuye Gebretsadik
Daniel Dejene Wondimagegnehu
Daniel Demissie Gebremariam
Birhan Moges Ejigu
Bethelhem Getu Bekele
Estifanos Tsigie
Degu Ashagrie Alemu
Mezgebu Nega Bizuneh
Yesewbelay Minale Negesse
Rajiha Abubeker Ibrahim
Abebe Aseffa Negeri
Getachew Tollera Eticha
Gemechu Tadese Leta
Negga Asamene Abera
Eyasu Tigabu Seyoum