Transdermal Estradiol Patches in Locally Advanced Prostate Cancer

R Ruth E. Langley (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) D Duncan C. Gilbert (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) S Stephen Mangar (Imperial College Healthcare NHS Trust, London) S Stuart Rosen (London Northwest and Royal Brompton Hospitals and Imperial College, London) E Ellie Bourmaki (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) H Hannah L. Rush (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) S Subramaniam Kananga Sundaram (Pinderfields Hospital Mid-Yorkshire Teaching NHS Trust, Wakefield, United Kingdom) A Abdulla Alhasso (Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom) R Roger Kockelbergh (Department of Urology, University Hospitals of Leicester, Leicester, United Kingdom) H Hoda Abdel-Aty (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) C Claire L. Amos (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) L Louise Brown (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) S Simon Brown C Charlene Carvalho (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) K Kitty Chan G Gerald Collins (Alexandra Hospital, Cheadle, United Kingdom) W William Cross (Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom) J John Deighan (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) S Sanjay Dixit (North-Lincolnshire and Goole Hospitals NHS Trust, Scunthorpe, United Kingdom) T Trinh Duong (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) J James Dyer (Stockport NHS Foundation Trust, Stockport, United Kingdom) J Joanna Gale (Portsmouth Hospitals University Trust, Portsmouth, United Kingdom) S Silke Gillessen (Oncology Institute of Southern Switzerland, Bellinzona, Switzerland) A Anna Griffiths (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) M Marc Laniado (Frimley Health NHS Foundation Trust, Slough, United Kingdom) A Anna Lydon (Torbay and South Devon NHS Foundation Trust, Torbay, United Kingdom) N Neil McPhail (Raigmore Hospital, Inverness, United Kingdom) A Archie MacNair (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) S Sanjeev Madaan (Darent Valley Hospital, Dartford, United Kingdom) J John Marshall (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) D David Matheson (Faculty of Education, Health, and Wellbeing, University of Wolverhampton, Walsall, United Kingdom) R Robin Millman (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) W Wael Mohamed (Singleton Hospital, Swansea University Health board, Swansea, United Kingdom) L Laura Murphy (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) K Krishna Narahari (University Hospital of Wales, Cardiff, United Kingdom) C Christopher Parker (Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London) M Miguel Panades (Lincoln County Hospital, Lincoln, United Kingdom) A Alvan Pope (Hillingdon Hospitals NHS Foundation Trust and Imperial College Healthcare NHS Trust, London) A Arpita Raval (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) A Angus Robinson (Sussex Cancer Centre, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom) M Martin Russell (Forth Valley Royal Hospital, Larbert, United Kingdom) C Christopher Scrase (Ipswich Hospital, East Suffolk and North Essex Foundation Trust Suffolk, Ipswich, United Kingdom) M Matthew Sydes (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) R Rafal Turo (Pinderfields Hospital Mid-Yorkshire Teaching NHS Trust, Wakefield, United Kingdom) R Ram Venkitaraman (Ipswich Hospital, East Suffolk and North Essex Foundation Trust Suffolk, Ipswich, United Kingdom) S Simona Wade (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) H Howard Kynaston (Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom) G Gerhardt Attard N Nicholas D. James (Institute of Cancer Research, Sutton, United Kingdom) N Noel Clarke (Christie and Salford Royal Hospitals, Manchester, United Kingdom) M Mahesh K. Parmar (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London) M Matthew Nankivell (MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London)

Article Details

Volume / Issue Vol. 394, Issue 16
Published April 23, 2026
Pages 1595-1607
ISSN 0028-4793
Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (52)

R

Ruth E. Langley

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

D

Duncan C. Gilbert

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

S

Stephen Mangar

Imperial College Healthcare NHS Trust, London

S

Stuart Rosen

London Northwest and Royal Brompton Hospitals and Imperial College, London

E

Ellie Bourmaki

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

H

Hannah L. Rush

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

S

Subramaniam Kananga Sundaram

Pinderfields Hospital Mid-Yorkshire Teaching NHS Trust, Wakefield, United Kingdom

A

Abdulla Alhasso

Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom

R

Roger Kockelbergh

Department of Urology, University Hospitals of Leicester, Leicester, United Kingdom

H

Hoda Abdel-Aty

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

C

Claire L. Amos

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

L

Louise Brown

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

S

Simon Brown

C

Charlene Carvalho

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

K

Kitty Chan

G

Gerald Collins

Alexandra Hospital, Cheadle, United Kingdom

W

William Cross

Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

J

John Deighan

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

S

Sanjay Dixit

North-Lincolnshire and Goole Hospitals NHS Trust, Scunthorpe, United Kingdom

T

Trinh Duong

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

J

James Dyer

Stockport NHS Foundation Trust, Stockport, United Kingdom

J

Joanna Gale

Portsmouth Hospitals University Trust, Portsmouth, United Kingdom

S

Silke Gillessen

Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

A

Anna Griffiths

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

M

Marc Laniado

Frimley Health NHS Foundation Trust, Slough, United Kingdom

A

Anna Lydon

Torbay and South Devon NHS Foundation Trust, Torbay, United Kingdom

N

Neil McPhail

Raigmore Hospital, Inverness, United Kingdom

A

Archie MacNair

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

S

Sanjeev Madaan

Darent Valley Hospital, Dartford, United Kingdom

J

John Marshall

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

D

David Matheson

Faculty of Education, Health, and Wellbeing, University of Wolverhampton, Walsall, United Kingdom

R

Robin Millman

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

W

Wael Mohamed

Singleton Hospital, Swansea University Health board, Swansea, United Kingdom

L

Laura Murphy

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

K

Krishna Narahari

University Hospital of Wales, Cardiff, United Kingdom

C

Christopher Parker

Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London

M

Miguel Panades

Lincoln County Hospital, Lincoln, United Kingdom

A

Alvan Pope

Hillingdon Hospitals NHS Foundation Trust and Imperial College Healthcare NHS Trust, London

A

Arpita Raval

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

A

Angus Robinson

Sussex Cancer Centre, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom

M

Martin Russell

Forth Valley Royal Hospital, Larbert, United Kingdom

C

Christopher Scrase

Ipswich Hospital, East Suffolk and North Essex Foundation Trust Suffolk, Ipswich, United Kingdom

M

Matthew Sydes

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

R

Rafal Turo

Pinderfields Hospital Mid-Yorkshire Teaching NHS Trust, Wakefield, United Kingdom

R

Ram Venkitaraman

Ipswich Hospital, East Suffolk and North Essex Foundation Trust Suffolk, Ipswich, United Kingdom

S

Simona Wade

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

H

Howard Kynaston

Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom

G

Gerhardt Attard

N

Nicholas D. James

Institute of Cancer Research, Sutton, United Kingdom

N

Noel Clarke

Christie and Salford Royal Hospitals, Manchester, United Kingdom

M

Mahesh K. Parmar

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London

M

Matthew Nankivell

MRC (Medical Research Council) Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London