Total Synthesis of Enlicitide Decanoate

Hongming Li; David A. Thaisrivongs; Gao Shang; Yonggang Chen; Qinghao Chen; Lushi Tan; Kai-Jiong Xiao; Reed T. Larson; Jeffrey T. Kuethe; Joshua Lee; Nicholas R. Deprez; Andrew F. Nolting; Marc Poirier; Paul G. Bulger; Erik L. Regalado; Mirlinda Biba; Fuh-Rong Tsay; Jimmy DaSilva; Chris K. Prier; Christopher A. Strulson; Kerstin Zawatzky; Zhu Liu; Justin A. Newman; Kathleen Sokolowsky; Weijuan Tang; Kari Hullen; Nimisha Thakur; Cody Welch; Smit Patel; Yu He; Jing Xu; Narayan Variankaval; Artis Klapars; Jongrock Kong; Richard Desmond; Richard Varsolona; Peter E. Maligres; Carlos A. Pons Siepermann; Lee Robison; Tiffany Piou; Clara Hartmanshenn; Anagha Chandra; Anisha Patel; Marc R. Becker; Guiquan Liu; Jianjun Duan; Baoqiang Wan; Chengqian Xiao; Yongpeng Yuan; Xiaohui Cao; Lu Chen; Ruxia Yi; Zheng Wu; Minyi Feng; Donghong Li; Zhiyan Song; Yawei Dong; Julin Sun; Biao Li; Guangxin Shao; Louis-Charles Campeau; Jingjun Yin

doi:10.1021/jacs.4c15966

Journal of the American Chemical Society

Total Synthesis of Enlicitide Decanoate

H Hongming Li (Department of Process Research and Development) D David A. Thaisrivongs (Department of Process Research and Development) G Gao Shang (Department of Process Research and Development) Y Yonggang Chen (Department of Process Research and Development) Q Qinghao Chen (Department of Process Research and Development) L Lushi Tan (Department of Process Research and Development) K Kai-Jiong Xiao R Reed T. Larson (Department of Process Research and Development) J Jeffrey T. Kuethe (Department of Process Research and Development) J Joshua Lee (Department of Process Research and Development) N Nicholas R. Deprez (Department of Process Research and Development) A Andrew F. Nolting (Department of Process Research and Development) M Marc Poirier (Department of Process Research and Development) P Paul G. Bulger (Department of Analytical Research and Development) E Erik L. Regalado (Department of Analytical Research and Development) M Mirlinda Biba (Department of Analytical Research and Development) F Fuh-Rong Tsay (Department of Analytical Research and Development) J Jimmy DaSilva (Department of Analytical Research and Development) C Chris K. Prier (Department of Process Research and Development) C Christopher A. Strulson (Department of Analytical Research and Development) K Kerstin Zawatzky (Department of Analytical Research and Development) Z Zhu Liu (Institute of Special Materials and Technology) J Justin A. Newman (Analytical Research & Development) K Kathleen Sokolowsky (Department of Analytical Research and Development) W Weijuan Tang (Department of Analytical Research and Development) K Kari Hullen (Department of Analytical Research and Development) N Nimisha Thakur (Department of Analytical Research and Development) C Cody Welch (Department of Analytical Research and Development) S Smit Patel Y Yu He (Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China.) J Jing Xu N Narayan Variankaval (Department of Analytical Research and Development) A Artis Klapars (Department of Process Research and Development) J Jongrock Kong (Department of Process Research and Development) R Richard Desmond (Department of Process Research and Development) R Richard Varsolona (Department of Analytical Research and Development) P Peter E. Maligres (Department of Process Research and Development) C Carlos A. Pons Siepermann (Department of Process Research and Development) L Lee Robison (Department of Analytical Research and Development) T Tiffany Piou (Merck Research Laboratory, Department of Process Research and Development) C Clara Hartmanshenn (Department of Process Research and Development) A Anagha Chandra (Department of Process Research and Development) A Anisha Patel (Department of Analytical Research and Development) M Marc R. Becker (Department of Process Research and Development) G Guiquan Liu (Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China) J Jianjun Duan (Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China) B Baoqiang Wan (Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China) C Chengqian Xiao (Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China) Y Yongpeng Yuan (Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China) X Xiaohui Cao (Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China) L Lu Chen R Ruxia Yi (Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China) Z Zheng Wu (Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China) M Minyi Feng (Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China) D Donghong Li (Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China) Z Zhiyan Song (Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China) Y Yawei Dong (Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China) J Julin Sun (Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China) B Biao Li (Beijing Key Laboratory of Theory and Technology for Advanced Batteries Materials, School of Materials Science and Engineering) G Guangxin Shao (Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China) L Louis-Charles Campeau (Department of Process Research and Development) J Jingjun Yin (Department of Process Research and Development)

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Article Details

Journal Journal of the American Chemical Society

Volume / Issue Vol. 147, Issue 13

Published April 02, 2025

Pages 11036-11048

DOI 10.1021/jacs.4c15966

ISSN 0002-7863

Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (62)

H

Hongming Li

Department of Process Research and Development

D

David A. Thaisrivongs

Department of Process Research and Development

G

Gao Shang

Department of Process Research and Development

Y

Yonggang Chen

Department of Process Research and Development

Q

Qinghao Chen

Department of Process Research and Development

L

Lushi Tan

Department of Process Research and Development

K

Kai-Jiong Xiao

R

Reed T. Larson

Department of Process Research and Development

J

Jeffrey T. Kuethe

Department of Process Research and Development

J

Joshua Lee

Department of Process Research and Development

N

Nicholas R. Deprez

Department of Process Research and Development

A

Andrew F. Nolting

Department of Process Research and Development

M

Marc Poirier

Department of Process Research and Development

P

Paul G. Bulger

Department of Analytical Research and Development

E

Erik L. Regalado

Department of Analytical Research and Development

M

Mirlinda Biba

Department of Analytical Research and Development

F

Fuh-Rong Tsay

Department of Analytical Research and Development

J

Jimmy DaSilva

Department of Analytical Research and Development

C

Chris K. Prier

Department of Process Research and Development

C

Christopher A. Strulson

Department of Analytical Research and Development

K

Kerstin Zawatzky

Department of Analytical Research and Development

Z

Zhu Liu

Institute of Special Materials and Technology

J

Justin A. Newman

Analytical Research & Development

K

Kathleen Sokolowsky

Department of Analytical Research and Development

W

Weijuan Tang

Department of Analytical Research and Development

K

Kari Hullen

Department of Analytical Research and Development

N

Nimisha Thakur

Department of Analytical Research and Development

C

Cody Welch

Department of Analytical Research and Development

S

Smit Patel

Y

Yu He

Department of Cardiovascular Surgery, Med-X Institute, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China.

J

Jing Xu

N

Narayan Variankaval

Department of Analytical Research and Development

A

Artis Klapars

Department of Process Research and Development

J

Jongrock Kong

Department of Process Research and Development

R

Richard Desmond

Department of Process Research and Development

R

Richard Varsolona

Department of Analytical Research and Development

P

Peter E. Maligres

Department of Process Research and Development

C

Carlos A. Pons Siepermann

Department of Process Research and Development

L

Lee Robison

Department of Analytical Research and Development

T

Tiffany Piou

Merck Research Laboratory, Department of Process Research and Development

C

Clara Hartmanshenn

Department of Process Research and Development

A

Anagha Chandra

Department of Process Research and Development

A

Anisha Patel

Department of Analytical Research and Development

M

Marc R. Becker

Department of Process Research and Development

G

Guiquan Liu

Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China

J

Jianjun Duan

Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China

B

Baoqiang Wan

Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China

C

Chengqian Xiao

Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China

Y

Yongpeng Yuan

Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China

X

Xiaohui Cao

Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China

L

Lu Chen

R

Ruxia Yi

Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China

Z

Zheng Wu

Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China

M

Minyi Feng

Shanghai SynTheAll Pharmaceutical Co., Ltd., No. 9 Yuegong Road, Jinshan District, Shanghai 201507, China

D

Donghong Li

Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China

Z

Zhiyan Song

Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China

Y

Yawei Dong

Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China

J

Julin Sun

Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China

B

Biao Li

Beijing Key Laboratory of Theory and Technology for Advanced Batteries Materials, School of Materials Science and Engineering

G

Guangxin Shao

Pharmaron Beijing Co., Ltd., No. 6, Tai-He Road, Beijing Economic and Technological Development Area, Beijing 100176, China

L

Louis-Charles Campeau

Department of Process Research and Development

J

Jingjun Yin

Department of Process Research and Development

Total Synthesis of Enlicitide Decanoate

Article Details

Journal Info

Authors (62)

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