Topology-Informed Design of Circularly Locked DNAzymes Enables Orthogonally Controlled Gene Regulation

F Fangzhi Yu (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience) S Siqi Zhang (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) H Huanyu Tao (School of Physics) H Haozhe Jin (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience) Y Yuliang Zhao (University of Chinese Academy of Sciences) S Sheng-You Huang (School of Physics) L Lele Li (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience)

Article Details

Volume / Issue Vol. 148, Issue 3
Published January 28, 2026
Pages 3365-3374
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (7)

F

Fangzhi Yu

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience

S

Siqi Zhang

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

H

Huanyu Tao

School of Physics

H

Haozhe Jin

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience

Y

Yuliang Zhao

University of Chinese Academy of Sciences

S

Sheng-You Huang

School of Physics

L

Lele Li

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience