Tirzepatide Regulates Pacemaker Function by Modulating cAMP and Calcium Dynamics in Human Sinoatrial Node Cells

Lu Ren

State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry

Nadjet Belbachir

Stanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).

Hao Zhang

Phung N. Thai

Rihua Huang

Wenjuan Zhu

Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany

Xuekun Wu

Mengjie Xie

Stanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).

Jingshan Gao

Stanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).

Hyeon Yu Kim

Stanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).

Tianding Liu

Stanford Cardiovascular Institute, Stanford University, CA (L.R., N.B., H.Z., R.H., W.Z., X.W., M.X., J.G., H.Y.K., T.L., J.S., J.C.W.).

Junyi Sun

Zaniar Ghazizadeh

Manuel F. Navedo

Department of Pharmacology, University of California Davis School of Medicine

Joseph C. Wu