Time of infusion does not significantly impact outcomes following CAR T-cell therapy in large B-cell lymphoma
Abstract
Abstract In this retrospective analysis of 584 patients who received chimeric antigen receptor T-cell therapy for large B-cell lymphoma at 6 Australian centers, no association was found between time of infusion and outcome, accounting for confounders, suggesting minimal clinical impact of chronobiology in this setting.
Article Details
Authors (23)
Mark R. Dowling
1Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia
Edward R. Scheffer Cliff
1Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia
Anthony Jeffrey
4Department of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia
Catelyn Cashion
6Blood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Sydney, Australia
Stephen Boyle
7Cancer Care Services, Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Brisbane, Australia
Jian Li
Thomas Buss
12Department of Haematology, Fiona Stanley Hospital, Murdoch, Australia
Ross MacDonald
7Cancer Care Services, Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Brisbane, Australia
Anastasia Edelkina
3Centre of Excellence in Cellular Immunotherapy, Peter MacCallum Cancer Centre, Melbourne, Australia
Hamish W. Scott
1Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia
Nicole L. O’Leary
1Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia
Michelle W. Keir
4Department of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia
Safia Belbachir
12Department of Haematology, Fiona Stanley Hospital, Murdoch, Australia
David A. Westerman
1Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia
Constantine S. Tam
40Department of Haematology, Alfred Hospital and Monash University, Melbourne, VIC, Australia
P. Joy Ho
4Department of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia
Simon J. Harrison
Allison Barraclough
12Department of Haematology, Fiona Stanley Hospital, Murdoch, Australia
Shafqat Inam
10Malignant Haematology, Transplantation and Cellular Therapy Service, Alfred Hospital, Melbourne, Australia
Emily Blyth
5Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
Andrea S. Henden
7Cancer Care Services, Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Brisbane, Australia
Vinay Vanguru
4Department of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia
Michael J. Dickinson
1Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia