Thiol-Retaining N-Terminal Cysteine Chemistry for Dual Modification and Bicyclic Peptide Construction

J Junjie Liu (Institute of Molecular Physiology) S Shixiang Duan (Institute of Molecular Physiology) Y Yang Huang (Guizhou Provincial Key Laboratory of Innovation and Manufacturing for Pharmaceuticals, School of Pharmacy) M Ming-Yi Jian (Department of Applied Chemistry) H Hsuan Suan Lee (Institute of Molecular Physiology) G Gaocan Dai (Institute of Molecular Physiology) C Chuanliu Wu (Department of Chemistry, College of Chemistry and Chemical Engineering, the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces) Y Yi-Lin Wu (Department of Applied Chemistry) Y Yu-Hsuan Tsai (Institute of Molecular Physiology)

Article Details

Volume / Issue Vol. 148, Issue 17
Published May 06, 2026
Pages 18020-18029
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (9)

J

Junjie Liu

Institute of Molecular Physiology

S

Shixiang Duan

Institute of Molecular Physiology

Y

Yang Huang

Guizhou Provincial Key Laboratory of Innovation and Manufacturing for Pharmaceuticals, School of Pharmacy

M

Ming-Yi Jian

Department of Applied Chemistry

H

Hsuan Suan Lee

Institute of Molecular Physiology

G

Gaocan Dai

Institute of Molecular Physiology

C

Chuanliu Wu

Department of Chemistry, College of Chemistry and Chemical Engineering, the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces

Y

Yi-Lin Wu

Department of Applied Chemistry

Y

Yu-Hsuan Tsai

Institute of Molecular Physiology