The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies
Abstract
Abstract Han Chinese people comprise nearly 20% of the global population but remain under-represented in genetic studies 1,2 , so there is an urgent need for large-scale cohorts to advance precision medicine. Here we present the Taiwan Precision Medicine Initiative (TPMI), established by Academia Sinica in collaboration with 16 major medical centres around Taiwan, which has recruited 565,390 participants who consent to provide DNA samples for genetic profiling and grant access to their electronic medical records (EMRs) for research. EMR access is both retrospective and prospective, allowing longitudinal studies. Genetic profiling is done with population-optimized arrays of single-nucleotide polymorphisms for people of Han Chinese ancestry, which enable genome-wide association 3,4 , phenome-wide association 5,6 and polygenic risk score 7,8 studies to be performed to evaluate common disease risk and pharmacogenetic response. Participants also agreed to be re-contacted for future research and receive personalized genetic risk profiles with health management recommendations. The TPMI has established the TPMI Data Access Platform, a central database and analysis platform that both safeguards the security of the data and facilitates academic research. As a large cohort of individuals with non-European ancestry that merges genetic profiles with EMR data and enables longitudinal follow-up, TPMI provides a unique resource that could be used to validate genetic risk prediction models, perform clinical trials of risk-based health management and inform health policies. Ultimately, the TPMI cohort will contribute to global genetic research and serve as a model for population-based precision medicine.
Article Details
Authors (143)
Hsin-Chou Yang
Pui-Yan Kwok
Ling-Hui Li
Yi-Min Liu
Yuh-Jyh Jong
Kang-Yun Lee
Da-Wei Wang
Ming-Fang Tsai
Jenn-Hwai Yang
Chien-Hsiun Chen
Erh-Chan Yeh
Chun-yu Wei
Cathy S.-J. Fann
Yen-Tsung Huang
Chia-Wei Chen
Yi-Ju Lee
Shih-Kai Chu
Chih-hsing Ho
Cheng-Shin Yang
Yungling Leo Lee
Hung-Hsin Chen
Ming-Chih Hou
Jeng-Fong Chiou
Shun-Fa Yang
Chih-Hung Wang
Chih-Yang Huang
Kuan-Ming Chiu
Ming Chen
Fu-Tien Chiang
Sing-Lian Lee
Shiou-Sheng Chen
Wei-Jen Yao
Chih-Cheng Chien
Shih-Yao Lin
Fu-Pang Chang
Hsiang-Ling Ho
Yi-Chen Yeh
Wei-Cheng Tseng
Ming-Hwai Lin
Hsiao-Ting Chang
Ling-Ming Tseng
Wen-Yih Liang
Paul Chih-Hsueh Chen
Jen-Fan Hang
Shih-Chieh Lin
Yu-Jiun Chan
Ying-Ju Kuo
Lei-Chi Wang
Chin-Chen Pan
Yu-Cheng Hsieh
Yi-Ming Chen
Tzu-Hung Hsiao
Ching-Heng Lin
Yen-Ju Chen
I-Chieh Chen
Chien-Lin Mao
Shu-Jung Chang
Yen-Lin Chang
Yi-Ju Liao
Chih-Hung Lai
Wei-Ju Lee
Hsin Tung
Ting-Ting Yen
Hsin-Chien Yen
Chun-Ming Shih
Teh-Ying Chou
Tsan-Hon Liou
Chen-Yuan Chiang
Yih-Giun Cherng
Chih-Hwa Chen
Chao-Hua Chiu
Sung-Hui Tseng
Emily Pei-Ying Lin
Ying-Ju Chen
Hui-Ping Chuang
Tsai-Chuan Chen
Wei-Ting Huang
Joey Sin
I-Ling Liu
Yi-Chen Chen
Kuo-Kuang Chao
Yu-Min Wu
Pin-Pin Yu
Lung-Pao Chang
Kuei-Yao Yen
Li-Ching Chang
Yi-Jing Sheen
Yuan-Tsong Chen
Kamhon Kan
Hsiang-Lin Tsai
Yao-Kuang Wang
Ming-Feng Hou
Yuan-Han Yang
Chao-Hung Kuo
Wen-Jeng Wu
Jee-Fu Huang
Inn-Wen Chong
Jong-Rung Tsai
Cheng-Yu Lin
Ming-Chin Yu
Tsong-Hai Lee
Meng-Han Tsai
Yu-Che Ou
Pin-Yuan Chen
Tsung-Hui Hu
Yu-Chiau Shyu
Chih-Kuang Cheng
Yu-Jen Fang
Song-Chou Hsieh
Chien-Hung Chen
Chieh-Chang Chen
Ko-Jen Li
Chin-Hsien Lin
Hsien-Yi Chiu
Chen-Chi Wu
Chun-Yen Chen
Shi-Jye Chu
Feng-Cheng Liu
Fu-Chi Yang
Hsin-An Chang
Wei-liang Chen
Sung-Sen Yang
Yueh-feng Sung
Tso-Fu Wang
Shinn-Zong Lin
Yen-Wen Wu
Chien-Sheng Wu
Ju-Ying Jiang
Gwo-Chin Ma
Ting-Yu Chang
Juey-Jen Hwang
Kuo-Jang Kao
Chen-Fang Hung
Ting-Fang Chiu
Po-Yueh Chen
Kochung Tsui
Ming-Shiang Wu
See-Tong Pang
Shih-Ann Chen
Wei-Ming Chen
Chun-houh Chen
Wayne Huey-Herng Sheu
Jer-Yuarn Wu