The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

Joan Kyula-Currie; Victoria Roulstone; James Wright; Francesca Butera; Arnaud Legrand; Richard Elliott; Martin McLaughlin; Galabina Bozhanova; Dragomir Krastev; Stephen Pettitt; Tencho Tenev; Magnus Dillon; Shane Foo; Emmanuel C. Patin; Victoria Jennings; Charleen Chan Wah Hak; Elizabeth Appleton; Amarin Wongariyapak; Malin Pedersen; Antonio Rullan; Jyoti Choudhary; Chris Bakal; Pascal Meier; Christopher J. Lord; Alan Melcher; Kevin J. Harrington

doi:10.1038/s41467-025-61297-w

The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

J Joan Kyula-Currie V Victoria Roulstone J James Wright F Francesca Butera A Arnaud Legrand R Richard Elliott M Martin McLaughlin G Galabina Bozhanova D Dragomir Krastev S Stephen Pettitt T Tencho Tenev M Magnus Dillon S Shane Foo E Emmanuel C. Patin V Victoria Jennings C Charleen Chan Wah Hak E Elizabeth Appleton A Amarin Wongariyapak M Malin Pedersen A Antonio Rullan J Jyoti Choudhary C Chris Bakal P Pascal Meier C Christopher J. Lord A Alan Melcher K Kevin J. Harrington (Institute of Cancer Research, Royal Marsden Hospital, London)

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published July 08, 2025

DOI 10.1038/s41467-025-61297-w

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (26)

J

Joan Kyula-Currie

V

Victoria Roulstone

J

James Wright

F

Francesca Butera

A

Arnaud Legrand

R

Richard Elliott

M

Martin McLaughlin

G

Galabina Bozhanova

D

Dragomir Krastev

S

Stephen Pettitt

T

Tencho Tenev

M

Magnus Dillon

S

Shane Foo

E

Emmanuel C. Patin

V

Victoria Jennings

C

Charleen Chan Wah Hak

E

Elizabeth Appleton

A

Amarin Wongariyapak

M

Malin Pedersen

A

Antonio Rullan

J

Jyoti Choudhary

C

Chris Bakal

P

Pascal Meier

C

Christopher J. Lord

A

Alan Melcher

K

Kevin J. Harrington

Institute of Cancer Research, Royal Marsden Hospital, London

The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

Article Details

Journal Info

Authors (26)

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