The One Ring: A Monocycle Producing Class II Diterpene Cyclase from <i>Isodon leucophyllus</i>

Y Yiting Mei (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs) J Jiali Zhou (State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics) J Jun Xie (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs) H Haobin Zhang (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs) I Ian S. Torrence (Department of Chemistry) M Meimei Xu (Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology) J Jingbo Li (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs) M Miaomiao Liang (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs) J Jingyi Li J Justin B. Siegel (Department of Chemistry) R Reuben J. Peters D Dean J. Tantillo (Department of Chemistry, University of California Davis, One Shields Ave. Davis, Sacramento, California 95616, United States) M Meirong Jia (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs)

Article Details

Volume / Issue Vol. 148, Issue 22
Published June 10, 2026
Pages 22769-22781
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (13)

Y

Yiting Mei

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs

J

Jiali Zhou

State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics

J

Jun Xie

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs

H

Haobin Zhang

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs

I

Ian S. Torrence

Department of Chemistry

M

Meimei Xu

Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology

J

Jingbo Li

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs

M

Miaomiao Liang

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs

J

Jingyi Li

J

Justin B. Siegel

Department of Chemistry

R

Reuben J. Peters

D

Dean J. Tantillo

Department of Chemistry, University of California Davis, One Shields Ave. Davis, Sacramento, California 95616, United States

M

Meirong Jia

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs