The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity

T Tania Valencia L Laura Y. Yen C Cindy Berman T Thomas Vincent S Scott Davis F Francesca Varrone J Jianfeng Huang (National Innovation Center for Industry-Education Integration of Energy Storage Technology, Institute of Advanced Interdisciplinary Studies, School of Chemistry and Chemical Engineering) J Jessica Mastroianni M Morgan Carlson T Tate Owen A Amin Kamel D Denis Drygin G Garth A. Kinberger S Shanti Pal Gangwar M Maria V. Yelshanskaya J John Ridley R Robert Kirby J Jesus Alvarez R Ronak Lakhia V Vishal Patel A Alexander I. Sobolevsky (Department of Biochemistry and Molecular Biophysics, Columbia University) E Edmund C. Lee