The Discovery and Development of an Iridium‐Catalyzed N→C Alkyl Transfer Reaction
Abstract
AbstractUnder Ir‐catalyzed conditions, N‐2°‐alkyl or N‐3°‐alkyl substituents of diverse tertiary aryl amides can be exchanged with the ortho‐aryl C─H bond of the aromatic unit. These alkyl transfer processes employ a homochiral diphosphonite ligand, and this enforces notable levels of enantioconvergency for non‐stereodefined 2°‐alkyl substituents. Related processes allow the intermolecular transfer of N‐2°‐alkyl substituents, providing a convenient means of introducing difficult‐to‐install ortho‐alkyl units.
Article Details
Authors (6)
Erin C. Boddie
Department of Chemistry University of Liverpool Crown Street Liverpool L69 7ZD UK
Phillippa Cooper
School of Chemistry University of Bristol Bristol BS8 1TS UK
L. Anders Hammarback
Department of Chemistry
Richard J. Mudd
Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom
Lyman J. Feron
Oncology R&D AstraZeneca The Discovery Centre Cambridge Biomedical Campus 1 Francis Crick Avenue Cambridge CB2 0AA UK
John F. Bower
Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom